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Intraductal breast neoplasm

MedGen UID:
184927
•Concept ID:
C0948967
•
Neoplastic Process
Synonyms: Breast Intraductal Neoplasm; Intraductal Breast Neoplasm; intraductal breast neoplasm
 
Monarch Initiative: MONDO:0002488

Definition

A benign or malignant epithelial neoplasm that arises anywhere in the ductal system of the breast. This category includes intraductal papilloma, intraductal papillary carcinoma, ductal hyperplasia with or without atypia, and ductal carcinoma in situ. [from NCI]

Professional guidelines

PubMed

Paget's disease of the breast: diagnosis and management.
Hudson-Phillips S, Cox K, Patel P, Al Sarakbi W
Br J Hosp Med (Lond) 2023 Jan 2;84(1):1-8. Epub 2023 Jan 24 doi: 10.12968/hmed.2022.0439. PMID: 36708338
Advances and controversies in management of breast ductal carcinoma in situ (DCIS).
Farante G, Toesca A, Magnoni F, Lissidini G, Vila J, Mastropasqua M, Viale G, Penco S, Cassano E, Lazzeroni M, Bonanni B, Leonardi MC, Ripoll-Orts F, Curigliano G, Orecchia R, Galimberti V, Veronesi P
Eur J Surg Oncol 2022 Apr;48(4):736-741. Epub 2021 Nov 9 doi: 10.1016/j.ejso.2021.10.030. PMID: 34772587
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487

Curated

UK NICE Guideline NG101, Early and locally advanced breast cancer: diagnosis and management, 2024

Recent clinical studies

Etiology

DCIS: Risk Assessment in the Molecular Era.
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
Margins in breast cancer: How much is enough?
Pilewskie M, Morrow M
Cancer 2018 Apr 1;124(7):1335-1341. Epub 2018 Jan 16 doi: 10.1002/cncr.31221. PMID: 29338088Free PMC Article
Mitigating overdiagnosis and overtreatment in breast cancer: what is the role of the pathologist?
Calhoun BC, Livasy CA
Arch Pathol Lab Med 2014 Nov;138(11):1428-31. Epub 2014 Mar 14 doi: 10.5858/arpa.2013-0763-ED. PMID: 24628451

Diagnosis

Treatment Landscape of Ductal Carcinoma In Situ.
Chelariu-Raicu A, Harbeck N
Chirurgia (Bucur) 2021 Dec;116(5 Suppl):S76-S82. doi: 10.21614/chirurgia.116.5.suppl.S76. PMID: 34967314
Papillary neoplasms of the breast including upgrade rates and management of intraductal papilloma without atypia diagnosed at core needle biopsy.
Brogi E, Krystel-Whittemore M
Mod Pathol 2021 Jan;34(Suppl 1):78-93. Epub 2020 Oct 26 doi: 10.1038/s41379-020-00706-5. PMID: 33106592
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
RTOG 9804: a prospective randomized trial for good-risk ductal carcinoma in situ comparing radiotherapy with observation.
McCormick B, Winter K, Hudis C, Kuerer HM, Rakovitch E, Smith BL, Sneige N, Moughan J, Shah A, Germain I, Hartford AC, Rashtian A, Walker EM, Yuen A, Strom EA, Wilcox JL, Vallow LA, Small W Jr, Pu AT, Kerlin K, White J
J Clin Oncol 2015 Mar 1;33(7):709-15. Epub 2015 Jan 20 doi: 10.1200/JCO.2014.57.9029. PMID: 25605856Free PMC Article
Mitigating overdiagnosis and overtreatment in breast cancer: what is the role of the pathologist?
Calhoun BC, Livasy CA
Arch Pathol Lab Med 2014 Nov;138(11):1428-31. Epub 2014 Mar 14 doi: 10.5858/arpa.2013-0763-ED. PMID: 24628451

Therapy

Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Chua BH, Link EK, Kunkler IH, Whelan TJ, Westenberg AH, Gruber G, Bryant G, Ahern V, Purohit K, Graham PH, Akra M, McArdle O, O'Brien P, Harvey JA, Kirkove C, Maduro JH, Campbell ID, Delaney GP, Martin JD, Vu TTT, Muanza TM, Neal A, Olivotto IA; BIG 3–07/TROG 07.01 trial investigators
Lancet 2022 Aug 6;400(10350):431-440. doi: 10.1016/S0140-6736(22)01246-6. PMID: 35934006
Randomized Phase III Trial Evaluating Radiation Following Surgical Excision for Good-Risk Ductal Carcinoma In Situ: Long-Term Report From NRG Oncology/RTOG 9804.
McCormick B, Winter KA, Woodward W, Kuerer HM, Sneige N, Rakovitch E, Smith BL, Germain I, Hartford AC, O'Rourke MA, Walker EM, Strom EA, Hopkins JO, Pierce LJ, Pu AT, Sumida KNM, Vesprini D, Moughan J, White JR
J Clin Oncol 2021 Nov 10;39(32):3574-3582. Epub 2021 Aug 18 doi: 10.1200/JCO.21.01083. PMID: 34406870Free PMC Article
Diagnosis and Treatment of Breast Cancer in Men.
Zehr KR
Radiol Technol 2019 Sep;91(1):51M-61M. PMID: 31471487
Accelerated Partial Breast Irradiation: Executive summary for the update of an ASTRO Evidence-Based Consensus Statement.
Correa C, Harris EE, Leonardi MC, Smith BD, Taghian AG, Thompson AM, White J, Harris JR
Pract Radiat Oncol 2017 Mar-Apr;7(2):73-79. Epub 2016 Sep 17 doi: 10.1016/j.prro.2016.09.007. PMID: 27866865
The benefits and harms of breast cancer screening: an independent review.
Independent UK Panel on Breast Cancer Screening
Lancet 2012 Nov 17;380(9855):1778-86. Epub 2012 Oct 30 doi: 10.1016/S0140-6736(12)61611-0. PMID: 23117178

Prognosis

Breast Tangent Beam Energy, Surgical Bed-to-Skin Distance and Local Recurrence After Breast-Conserving Treatment.
Nichol A, Narinesingh D, Wade L, Raman S, Gondara L, Speers C, Tran E, Chan EK, Lohrisch CA, Truong P
Int J Radiat Oncol Biol Phys 2022 Mar 1;112(3):671-680. Epub 2021 Oct 23 doi: 10.1016/j.ijrobp.2021.10.014. PMID: 34699929
Are we overtreating intraductal papillomas?
Kiran S, Jeong YJ, Nelson ME, Ring A, Johnson MB, Sheth PA, Ma Y, Sener SF, Lang JE
J Surg Res 2018 Nov;231:387-394. Epub 2018 Jun 29 doi: 10.1016/j.jss.2018.06.008. PMID: 30278958Free PMC Article
Surgical Excision Without Radiation for Ductal Carcinoma in Situ of the Breast: 12-Year Results From the ECOG-ACRIN E5194 Study.
Solin LJ, Gray R, Hughes LL, Wood WC, Lowen MA, Badve SS, Baehner FL, Ingle JN, Perez EA, Recht A, Sparano JA, Davidson NE
J Clin Oncol 2015 Nov 20;33(33):3938-44. Epub 2015 Sep 14 doi: 10.1200/JCO.2015.60.8588. PMID: 26371148Free PMC Article
Clinical decision-making in early breast cancer.
Balch CM, Singletary SE, Bland KI
Ann Surg 1993 Mar;217(3):207-25. PMID: 8383953Free PMC Article
Minimal breast carcinoma.
Nevin JE, Pinzón G, Morán TJ, Baggerly JT
Am J Surg 1980 Mar;139(3):357-9. doi: 10.1016/0002-9610(80)90293-7. PMID: 6244748

Clinical prediction guides

DCIS: Risk Assessment in the Molecular Era.
Knowlton CA, Jimenez RB, Moran MS
Semin Radiat Oncol 2022 Jul;32(3):189-197. doi: 10.1016/j.semradonc.2022.01.005. PMID: 35688517
Improving DCIS diagnosis and predictive outcome by applying artificial intelligence.
Hayward MK, Weaver VM
Biochim Biophys Acta Rev Cancer 2021 Aug;1876(1):188555. Epub 2021 Apr 29 doi: 10.1016/j.bbcan.2021.188555. PMID: 33933557Free PMC Article
The Clinical Utility of DCISionRT(®) on Radiation Therapy Decision Making in Patients with Ductal Carcinoma In Situ Following Breast-Conserving Surgery.
Shah C, Bremer T, Cox C, Whitworth P, Patel R, Patel A, Brown E, Gold L, Rock D, Riley L, Kesslering C, Brown S, Gabordi R, Pellicane J, Rabinovich R, Khan S, Templeton S, Majithia L, Willey SC, Wärnberg F, Gerber NK, Shivers S, Vicini FA
Ann Surg Oncol 2021 Oct;28(11):5974-5984. Epub 2021 Apr 5 doi: 10.1245/s10434-021-09903-1. PMID: 33821346Free PMC Article
Is DCIS Overrated?
Feinberg J, Wetstone R, Greenstein D, Borgen P
Cancer Treat Res 2018;173:53-72. doi: 10.1007/978-3-319-70197-4_5. PMID: 29349758
Borderline breast lesions: diagnostic challenges and clinical implications.
Masood S, Rosa M
Adv Anat Pathol 2011 May;18(3):190-8. doi: 10.1097/PAP.0b013e31821698cc. PMID: 21490436

Recent systematic reviews

Impact of comedonecrosis on prostate cancer outcome: a systematic review.
Aiyer KTS, Kroon LJ, van Leenders GJLH
Histopathology 2023 Sep;83(3):339-347. Epub 2023 May 17 doi: 10.1111/his.14945. PMID: 37195595
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Partial breast irradiation versus whole breast radiotherapy for early breast cancer.
Hickey BE, Lehman M
Cochrane Database Syst Rev 2021 Aug 30;8(8):CD007077. doi: 10.1002/14651858.CD007077.pub4. PMID: 34459500Free PMC Article
Benefits and harms of breast cancer screening with mammography in women aged 40-49 years: A systematic review.
van den Ende C, Oordt-Speets AM, Vroling H, van Agt HME
Int J Cancer 2017 Oct 1;141(7):1295-1306. Epub 2017 Jun 5 doi: 10.1002/ijc.30794. PMID: 28542784
Nipple- and areola-sparing mastectomy for the treatment of breast cancer.
Mota BS, Riera R, Ricci MD, Barrett J, de Castria TB, Atallah ÁN, Bevilacqua JL
Cochrane Database Syst Rev 2016 Nov 29;11(11):CD008932. doi: 10.1002/14651858.CD008932.pub3. PMID: 27898991Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2024
      UK NICE Guideline NG101, Early and locally advanced breast cancer: diagnosis and management, 2024

    Consumer resources

    Reviews

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      Related information in PubMed Central Links
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      Related literature resources in PubMed

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