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Oncocytic neoplasm

MedGen UID:
237181
•Concept ID:
C1378050
•
Neoplastic Process
Synonyms: Oncocytic Neoplasm; oncocytic neoplasm; Oncocytic Tumor; oncocytic tumor; oncocytic tumour; Oncocytoma; oncocytoma, benign
 
Monarch Initiative: MONDO:0010795

Definition

A usually benign neoplasm composed of large cells with abundant eosinophilic granular cytoplasm. Representative examples include oncocytic neoplasms of the thyroid gland, and kidney. (NCI05) [from NCI]

Professional guidelines

PubMed

Reliability and Management Outcomes Following a Percutaneous Biopsy Diagnosis of Oncocytoma: A 15-year Retrospective Analysis.
Chai JL, Alencar RO, Hirsch MS, Bhagavatula S, Bay CP, Siegmund S, Chang SL, Silverman SG
Radiology 2023 Apr;307(2):e221156. Epub 2023 Jan 24 doi: 10.1148/radiol.221156. PMID: 36692400
Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.
Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Kunju LP, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, Gupta NS
Hum Pathol 2017 May;63:149-156. Epub 2017 Mar 14 doi: 10.1016/j.humpath.2017.03.004. PMID: 28315424
The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma.
Boris RS, Benhammou J, Merino M, Pinto PA, Linehan WM, Bratslavsky G
J Urol 2011 Jun;185(6):2050-5. Epub 2011 Apr 15 doi: 10.1016/j.juro.2011.02.051. PMID: 21496834Free PMC Article

Recent clinical studies

Etiology

Oncocytic/Hürthle cell lesions have the same implied risk of neoplasm/malignancy as their follicular counterparts.
Lin D, Hanna CA, Frost A, Wrenn A, Eltoum I
Cytopathology 2024 Nov;35(6):733-737. Epub 2024 Jul 16 doi: 10.1111/cyt.13424. PMID: 39012032
Low grade oncocytic renal tumor (LOT): Clinicopathological characterization of 13 cases.
Almutairi F, Xu B
Pathol Res Pract 2024 Feb;254:155127. Epub 2024 Jan 12 doi: 10.1016/j.prp.2024.155127. PMID: 38241777
Etiology of Small Echogenic Renal Masses.
Kwong A, Mitchell A, Wang D, McGahan JP
J Ultrasound Med 2022 Oct;41(10):2567-2575. Epub 2022 Jan 19 doi: 10.1002/jum.15946. PMID: 35043978
Pathological characteristics of the large renal mass: potential implication for clinical role of renal biopsy.
Asghar AM, McIntosh AG, Smith ZL, Kocher NJ, Lee Z, Barashi NN, Li T, Raman JD, Eggener SE, Uzzo RG, Kutikov A
Can J Urol 2021 Apr;28(2):10620-10624. PMID: 33872561
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415

Diagnosis

Pathological characteristics of the large renal mass: potential implication for clinical role of renal biopsy.
Asghar AM, McIntosh AG, Smith ZL, Kocher NJ, Lee Z, Barashi NN, Li T, Raman JD, Eggener SE, Uzzo RG, Kutikov A
Can J Urol 2021 Apr;28(2):10620-10624. PMID: 33872561
Adrenocortical neoplasm of uncertain malignant potential with a myelolipomatous component.
Balasubramanian A, Scovell J, Dowell AE, Mayer W
BMJ Case Rep 2020 Jun 11;13(6) doi: 10.1136/bcr-2020-234591. PMID: 32532913Free PMC Article
Pink renal conundrum.
Sanders ML, Thomas DH, Varma M
J Clin Pathol 2020 Sep;73(9):610. Epub 2020 Feb 14 doi: 10.1136/jclinpath-2019-206260. PMID: 32060077
Unravelling Adrenal Oncocytic Neoplasm.
Virarkar M, Patnana M, Vikram R, Bhargava P, Birkenfeld E, Sagebiel T
Clin Genitourin Cancer 2019 Feb;17(1):e216-e220. Epub 2018 Oct 26 doi: 10.1016/j.clgc.2018.10.011. PMID: 30454970
Oncocytic Neoplasm on Renal Mass Biopsy: A Diagnostic Conundrum.
Gorin MA, Rowe SP, Allaf ME
Oncology (Williston Park) 2016 May;30(5):426-35. PMID: 27188673

Therapy

Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses?
LaRussa S, Vanden Berg RW, Craig KM, Madoff DC, McClure TD
Cardiovasc Intervent Radiol 2020 Oct;43(10):1468-1473. Epub 2020 Jul 1 doi: 10.1007/s00270-020-02568-5. PMID: 32613266
Categorizing renal oncocytic neoplasms on core needle biopsy: a morphologic and immunophenotypic study of 144 cases with clinical follow-up.
Alderman MA, Daignault S, Wolf JS Jr, Palapattu GS, Weizer AZ, Hafez KS, Kunju LP, Wu AJ
Hum Pathol 2016 Sep;55:1-10. Epub 2016 Apr 13 doi: 10.1016/j.humpath.2016.03.017. PMID: 27085554
Diagnostic yield of renal biopsy immediately prior to laparoscopic radiofrequency ablation: a multicenter study.
Kyle CC, Wingo MS, Carey RI, Leveillee RJ, Bird VG
J Endourol 2008 Oct;22(10):2291-3. doi: 10.1089/end.2008.9717. PMID: 18937593
Cytogenetic and corresponding flow cytometric DNA analysis of renal cell neoplasms.
el-Naggar AK, Pathak S
Anticancer Res 1992 Sep-Oct;12(5):1491-500. PMID: 1444211

Prognosis

Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415
Unravelling Adrenal Oncocytic Neoplasm.
Virarkar M, Patnana M, Vikram R, Bhargava P, Birkenfeld E, Sagebiel T
Clin Genitourin Cancer 2019 Feb;17(1):e216-e220. Epub 2018 Oct 26 doi: 10.1016/j.clgc.2018.10.011. PMID: 30454970
Oncocytic Neoplasm on Renal Mass Biopsy: A Diagnostic Conundrum.
Gorin MA, Rowe SP, Allaf ME
Oncology (Williston Park) 2016 May;30(5):426-35. PMID: 27188673
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196
Metastatic renal oncocytic neoplasm with benign histologic appearance.
Jockle GA, Toker C, Shamsuddin AM
Urology 1987 Jul;30(1):79-81. doi: 10.1016/0090-4295(87)90581-4. PMID: 3603918

Clinical prediction guides

Oncocytic/Hürthle cell lesions have the same implied risk of neoplasm/malignancy as their follicular counterparts.
Lin D, Hanna CA, Frost A, Wrenn A, Eltoum I
Cytopathology 2024 Nov;35(6):733-737. Epub 2024 Jul 16 doi: 10.1111/cyt.13424. PMID: 39012032
Hyperandrogenism caused by a rare adrenocortical oncocytic neoplasm with uncertain malignant potential: a case report and review of the literature.
Bao Z, He W, Di W, Gao H
Endocr J 2023 Mar 28;70(3):275-280. Epub 2022 Nov 15 doi: 10.1507/endocrj.EJ22-0277. PMID: 36384706
Diagnostic criteria for oncocytic renal neoplasms: a survey of urologic pathologists.
Williamson SR, Gadde R, Trpkov K, Hirsch MS, Srigley JR, Reuter VE, Cheng L, Kunju LP, Barod R, Rogers CG, Delahunt B, Hes O, Eble JN, Zhou M, McKenney JK, Martignoni G, Fleming S, Grignon DJ, Moch H, Gupta NS
Hum Pathol 2017 May;63:149-156. Epub 2017 Mar 14 doi: 10.1016/j.humpath.2017.03.004. PMID: 28315424
Oncocytic Neoplasm on Renal Mass Biopsy: A Diagnostic Conundrum.
Gorin MA, Rowe SP, Allaf ME
Oncology (Williston Park) 2016 May;30(5):426-35. PMID: 27188673
Adrenocortical oncocytoma: case report with immunocytochemical and ultrastructural study.
Bégin LR
Virchows Arch A Pathol Anat Histopathol 1992;421(6):533-7. doi: 10.1007/BF01606884. PMID: 1281594

Recent systematic reviews

Adrenocortical oncocytic neoplasm: A systematic review.
Kanitra JJ, Hardaway JC, Soleimani T, Koehler TJ, McLeod MK, Kavuturu S
Surgery 2018 Dec;164(6):1351-1359. Epub 2018 Jul 21 doi: 10.1016/j.surg.2018.04.044. PMID: 30037428
Adrenal oncocytic neoplasm: a systematic review.
Mearini L, Del Sordo R, Costantini E, Nunzi E, Porena M
Urol Int 2013;91(2):125-33. Epub 2012 Nov 8 doi: 10.1159/000345141. PMID: 23147196

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