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Parathyroid oncocytic adenoma

MedGen UID:
233845
•Concept ID:
C1335351
•
Neoplastic Process
Synonyms: Parathyroid Gland Oncocytic Adenoma; parathyroid gland oncocytic adenoma; Parathyroid Gland Oxyphilic Adenoma; Parathyroid Oncocytic Adenoma; parathyroid oncocytic adenoma
 
Monarch Initiative: MONDO:0004305

Definition

A parathyroid gland adenoma composed predominantly or entirely of neoplastic cells with abundant granular eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParathyroid oncocytic adenoma

Professional guidelines

PubMed

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595

Recent clinical studies

Etiology

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Histopathological Features of Parathyroid Adenoma and 18F-Choline Uptake in PET/MR of Primary Hyperparathyroidism.
Liberini V, Morand GB, Rupp NJ, Orita E, Deandreis D, Broglie Däppen M, Hofbauer M, Maurer A, Husmann L, Mader CE, Grünig H, Alharbi AA, Messerli M, Huellner MW
Clin Nucl Med 2022 Feb 1;47(2):101-107. doi: 10.1097/RLU.0000000000003987. PMID: 35006103
Molecular profiles of oxyphilic and chief cell parathyroid adenoma.
Lu M, Kjellin H, Fotouhi O, Lee L, Nilsson IL, Haglund F, Höög A, Lehtiö J, Larsson C
Mol Cell Endocrinol 2018 Jul 15;470:84-95. Epub 2017 Oct 3 doi: 10.1016/j.mce.2017.10.001. PMID: 28986304
Inflammatory infiltrates in parathyroid tumors.
Haglund F, Hallström BM, Nilsson IL, Höög A, Juhlin CC, Larsson C
Eur J Endocrinol 2017 Dec;177(6):445-453. Epub 2017 Aug 30 doi: 10.1530/EJE-17-0277. PMID: 28855268Free PMC Article
Video-assisted endoscopic thyroidectomy.
Yeh TS, Jan YY, Hsu BR, Chen KW, Chen MF
Am J Surg 2000 Aug;180(2):82-5. doi: 10.1016/s0002-9610(00)00429-3. PMID: 11044518

Diagnosis

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Top 10 Clear Cell Head and Neck Lesions to Contemplate.
Cipriani NA, Kakkar A
Head Neck Pathol 2023 Mar;17(1):33-52. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01518-6. PMID: 36928734Free PMC Article
Oncocytic Parathyroid Adenoma.
McCarthy M, Whaley RD, Erickson LA
Mayo Clin Proc 2022 Nov;97(11):2168-2169. doi: 10.1016/j.mayocp.2022.09.015. PMID: 36333022
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276

Therapy

Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400
Ultrasound-guided fine-needle aspiration biopsy of the thyroid.
Tambouret R, Szyfelbein WM, Pitman MB
Cancer 1999 Oct 25;87(5):299-305. doi: 10.1002/(sici)1097-0142(19991025)87:5<299::aid-cncr10>3.0.co;2-m. PMID: 10536356
Parathyroid function and histology in patients with parathyroid adenoma: correlation of clinical and morphologic findings.
Luts L, Bergenfelz A, Alumets J, Sundler F
World J Surg 1997 Jun;21(5):553-63. doi: 10.1007/pl00012285. PMID: 9204747
Random cytochrome-C-oxidase deficiency of oxyphil cell nodules in the parathyroid gland. A mitochondrial cytopathy related to cell ageing?
Müller-Höcker J
Pathol Res Pract 1992 Aug;188(6):701-6. doi: 10.1016/s0344-0338(11)80165-2. PMID: 1332005

Prognosis

Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Immunohistochemistry in Diagnostic Parathyroid Pathology.
Erickson LA, Mete O
Endocr Pathol 2018 Jun;29(2):113-129. doi: 10.1007/s12022-018-9527-6. PMID: 29626276
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands.
Máximo V, Rios E, Sobrinho-Simões M
Int J Surg Pathol 2014 Feb;22(1):33-6. Epub 2014 Jan 9 doi: 10.1177/1066896913517938. PMID: 24406625
Parathyroid cytology: avoiding diagnostic pitfalls.
Absher KJ, Truong LD, Khurana KK, Ramzy I
Head Neck 2002 Feb;24(2):157-64. doi: 10.1002/hed.10003. PMID: 11891946
Oncocytic nodular hidradenoma.
Roth MJ, Stern JB, Hijazi Y, Haupt HM, Kumar A
Am J Dermatopathol 1996 Jun;18(3):314-6. doi: 10.1097/00000372-199606000-00013. PMID: 8806968

Clinical prediction guides

Molecular Alterations and Comprehensive Clinical Management of Oncocytic Thyroid Carcinoma: A Review and Multidisciplinary 2023 Update.
Bischoff LA, Ganly I, Fugazzola L, Buczek E, Faquin WC, Haugen BR, McIver B, McMullen CP, Newbold K, Rocke DJ, Russell MD, Ryder M, Sadow PM, Sherman E, Shindo M, Shonka DC Jr, Singer MC, Stack BC Jr, Wirth LJ, Wong RJ, Randolph GW
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):265-272. doi: 10.1001/jamaoto.2023.4323. PMID: 38206595
Oncocytic Change in Thyroid Pathology.
Asa SL, Mete O
Front Endocrinol (Lausanne) 2021;12:678119. Epub 2021 May 3 doi: 10.3389/fendo.2021.678119. PMID: 34012422Free PMC Article
Inflammatory infiltrates in parathyroid tumors.
Haglund F, Hallström BM, Nilsson IL, Höög A, Juhlin CC, Larsson C
Eur J Endocrinol 2017 Dec;177(6):445-453. Epub 2017 Aug 30 doi: 10.1530/EJE-17-0277. PMID: 28855268Free PMC Article
Oncocytic parathyroid adenoma.
Paul A, Villepelet A, Lefèvre M, Périé S
Eur Ann Otorhinolaryngol Head Neck Dis 2015 Nov;132(5):301-3. Epub 2015 Sep 11 doi: 10.1016/j.anorl.2015.08.033. PMID: 26364541
Oncocytic lesions of the thyroid, kidney, salivary glands, adrenal cortex, and parathyroid glands.
Máximo V, Rios E, Sobrinho-Simões M
Int J Surg Pathol 2014 Feb;22(1):33-6. Epub 2014 Jan 9 doi: 10.1177/1066896913517938. PMID: 24406625

Recent systematic reviews

Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis.
Coca-Pelaz A, Rodrigo JP, Shah JP, Sanabria A, Al Ghuzlan A, Silver CE, Shaha AR, Angelos P, Hartl DM, Mäkitie AA, Olsen KD, Owen RP, Randolph GW, Simó R, Tufano RP, Kowalski LP, Zafereo ME, Rinaldo A, Ferlito A
Adv Ther 2021 Oct;38(10):5144-5164. Epub 2021 Aug 22 doi: 10.1007/s12325-021-01876-7. PMID: 34423400

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