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Non-Neoplastic Ear Disorder

MedGen UID:
233770
•Concept ID:
C1335006
•
Disease or Syndrome
Synonym: Non-Neoplastic Ear Disease

Definition

A non-neoplastic disorder that affects the ear. Representative examples include infection, cholesteatoma, and hearing disorders. [from NCI]

Professional guidelines

PubMed

Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921
Management of intracranial neoplasms in children with neurofibromatosis type 1 and 2. The Children's Cancer Study Group.
Cohen BH, Kaplan AM, Packer RJ
Pediatr Neurosurg 1990-1991;16(2):66-72. doi: 10.1159/000120510. PMID: 2132927

Recent clinical studies

Etiology

Middle Ear "Adenoma": a Neuroendocrine Tumor with Predominant L Cell Differentiation.
Asa SL, Arkun K, Tischler AS, Qamar A, Deng FM, Perez-Ordonez B, Weinreb I, Bishop JA, Wenig BM, Mete O
Endocr Pathol 2021 Dec;32(4):433-441. Epub 2021 May 27 doi: 10.1007/s12022-021-09684-z. PMID: 34041698
Outcomes of interventional sialendoscopy for obstructive salivary gland disorders: an Italian multicentre study.
Gallo A, Capaccio P, Benazzo M, De Campora L, De Vincentiis M, Farneti P, Fusconi M, Gaffuri M, Lo Russo F, Martellucci S, Ottaviani F, Pagliuca G, Paludetti G, Pasquini E, Pignataro L, Puxeddu R, Rigante M, Scarano E, Sionis S, Speciale R, Canzi P
Acta Otorhinolaryngol Ital 2016 Dec;36(6):479-485. doi: 10.14639/0392-100X-1221. PMID: 28177330Free PMC Article
Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921
Correlation between the Voice Handicap Index and voice laboratory measurements after phonosurgery.
Cheng J, Woo P
Ear Nose Throat J 2010 Apr;89(4):183-8. PMID: 20397148
Lessons from the skin--cutaneous features of familial cancer.
Winship IM, Dudding TE
Lancet Oncol 2008 May;9(5):462-72. doi: 10.1016/S1470-2045(08)70126-8. PMID: 18452857

Diagnosis

Congenital cholesteatoma: what radiologists need to know.
Kwok HM, Cheung CHL, Ng TF, Lam SY, Wong KHS, Wong HL, Pan NY, Cheng LF, Ma KFJ
Pediatr Radiol 2024 Apr;54(4):620-634. Epub 2024 Feb 23 doi: 10.1007/s00247-024-05877-w. PMID: 38393651
Top 10 Nested Pattern Head and Neck Lesions to Notice.
Lott Limbach A, Chute DJ
Head Neck Pathol 2023 Mar;17(1):119-131. Epub 2023 Mar 16 doi: 10.1007/s12105-023-01534-0. PMID: 36928740Free PMC Article
Pathology of the vestibulocochlear nerve.
Swartz JD
Neuroimaging Clin N Am 2008 May;18(2):321-46, x-xi. doi: 10.1016/j.nic.2008.02.001. PMID: 18466835
Tumours of the external ear and temporal bone.
Devaney KO, Boschman CR, Willard SC, Ferlito A, Rinaldo A
Lancet Oncol 2005 Jun;6(6):411-20. doi: 10.1016/S1470-2045(05)70208-4. PMID: 15925819
Neurofibromatosis 1 and 2.
Pollack IF, Mulvihill JJ
Brain Pathol 1997 Apr;7(2):823-36. doi: 10.1111/j.1750-3639.1997.tb01067.x. PMID: 9161732Free PMC Article

Therapy

Long-term control of laryngeal plasma cell mucositis with systemic immunosuppression.
Triplett J, Hee G, McLean-Tooke A, Lucas M
BMJ Case Rep 2018 Jun 20;2018 doi: 10.1136/bcr-2017-221333. PMID: 29930164Free PMC Article
Evidence-based review of aetiopathogenic theories of congenital and acquired cholesteatoma.
Persaud R, Hajioff D, Trinidade A, Khemani S, Bhattacharyya MN, Papadimitriou N, Kalan A, Bhattacharyya AK
J Laryngol Otol 2007 Nov;121(11):1013-9. Epub 2007 Aug 15 doi: 10.1017/S0022215107000503. PMID: 17697435
Adjunctive use of endoscopy during posterior fossa surgery to treat cranial neuropathies.
King WA, Wackym PA, Sen C, Meyer GA, Shiau J, Deutsch H
Neurosurgery 2001 Jul;49(1):108-15; discussion 115-6. doi: 10.1097/00006123-200107000-00017. PMID: 11440431
Wegener's granulomatosis of the head and neck.
O'Devaney K, Ferlito A, Hunter BC, Devaney SL, Rinaldo A
Ann Otol Rhinol Laryngol 1998 May;107(5 Pt 1):439-45. doi: 10.1177/000348949810700515. PMID: 9596226

Prognosis

Congenital cholesteatoma: what radiologists need to know.
Kwok HM, Cheung CHL, Ng TF, Lam SY, Wong KHS, Wong HL, Pan NY, Cheng LF, Ma KFJ
Pediatr Radiol 2024 Apr;54(4):620-634. Epub 2024 Feb 23 doi: 10.1007/s00247-024-05877-w. PMID: 38393651
Aggressive low grade middle ear adenocarcinoma with multiple recurrences: a case report.
Elhefnawy NG
Diagn Pathol 2011 Jul 7;6:62. doi: 10.1186/1746-1596-6-62. PMID: 21736736Free PMC Article
Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921
Rare lesions of the cerebellopontine angle.
Yilmaz C, Altinors N, Sonmez E, Gulsen S, Caner H
Turk Neurosurg 2010 Jul;20(3):390-7. doi: 10.5137/1019-5149.JTN.2961-10.0. PMID: 20669114
Matrix metalloproteinases and their inhibitors in non-neoplastic otorhinolaryngological disease.
De S, Fenton JE, Jones AS
J Laryngol Otol 2005 Jun;119(6):436-42. doi: 10.1258/0022215054273269. PMID: 15992468

Clinical prediction guides

Chromodomain Helicase DNA-Binding Protein 7 Is Suppressed in the Perinecrotic/Ischemic Microenvironment and Is a Novel Regulator of Glioblastoma Angiogenesis.
Boyd NH, Walker K, Ayokanmbi A, Gordon ER, Whetsel J, Smith CM, Sanchez RG, Lubin FD, Chakraborty A, Tran AN, Herting C, Hambardzumyan D, Yancey Gillespie G, Hackney JR, Cooper SJ, Jiao K, Hjelmeland AB
Stem Cells 2019 Apr;37(4):453-462. Epub 2019 Jan 24 doi: 10.1002/stem.2969. PMID: 30629778Free PMC Article
Outcomes of interventional sialendoscopy for obstructive salivary gland disorders: an Italian multicentre study.
Gallo A, Capaccio P, Benazzo M, De Campora L, De Vincentiis M, Farneti P, Fusconi M, Gaffuri M, Lo Russo F, Martellucci S, Ottaviani F, Pagliuca G, Paludetti G, Pasquini E, Pignataro L, Puxeddu R, Rigante M, Scarano E, Sionis S, Speciale R, Canzi P
Acta Otorhinolaryngol Ital 2016 Dec;36(6):479-485. doi: 10.14639/0392-100X-1221. PMID: 28177330Free PMC Article
Sialoendoscopy for diagnosis and treatment of non-neoplastic obstruction in the salivary glands.
Danquart J, Wagner N, Arndal H, Homøe P
Dan Med Bull 2011 Feb;58(2):A4232. PMID: 21299921
Correlation between the Voice Handicap Index and voice laboratory measurements after phonosurgery.
Cheng J, Woo P
Ear Nose Throat J 2010 Apr;89(4):183-8. PMID: 20397148
Benign mass lesions deep inside the temporal bone: imaging diagnosis for proper management.
Okada K, Ito K, Yamasoba T, Ishii M, Iwasaki S, Kaga K
Acta Otolaryngol Suppl 2007 Dec;(559):71-7. doi: 10.1080/03655230701597127. PMID: 18340574

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