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Intraductal breast papilloma

MedGen UID:
65944
•Concept ID:
C0238034
•
Neoplastic Process
Synonyms: breast duct papilloma; Breast Intraductal Papilloma; Breast intraductal papilloma; Breast Papilloma; breast papilloma; Duct papilloma of breast; Duct Papilloma of Breast; duct papilloma of breast; Duct Papilloma of the Breast; duct papilloma of the breast; Ductal Breast Papilloma; ductal breast papilloma; Intraduct papilloma of breast; Intraductal Breast Papilloma; intraductal breast papilloma; Intraductal Papilloma of Breast; intraductal papilloma of breast; Intraductal Papilloma of the Breast; intraductal papilloma of the breast; mammary duct papilloma; Papilloma of Breast; papilloma of breast; Papilloma of the Breast; papilloma of the breast
SNOMED CT: Duct papilloma of breast (254848002); Intraduct papilloma of breast (254848002)
 
HPO: HP:6000102
Monarch Initiative: MONDO:0021097

Definition

Intraductal papilloma is a benign tumor found within breast ducts. The abnormal proliferation of ductal epithelial cells causes growth. A solitary intraductal papilloma is usually found centrally posterior to the nipple affecting the central duct. Multiple intraductal papillomas are located peripherally, found in any breast quadrant affecting the peripheral ducts. [from HPO]

Conditions with this feature

Familial adenomatous polyposis 4
MedGen UID:
934686
•Concept ID:
C4310719
•
Disease or Syndrome
Familial adenomatous polyposis-4 is an autosomal recessive tumor predisposition syndrome characterized by the development of multiple colonic adenomas in adulthood, often with progression to colorectal cancer. Proliferative lesions in other tissues may also occur (summary by Adam et al., 2016). For a discussion of genetic heterogeneity of familial adenomatous polyposis, see FAP1 (175100).
See: Condition Record
Familial adenomatous polyposis 4

Professional guidelines

PubMed

Detailed Morphologic Evaluation of Breast Papillary Lesions on Core Biopsy Is Critical for Accurate Classification and Clinical Management: The Experience of an Academic Institute.
Petrolla A, Hicks DG, Skinner KA, Wang X
Clin Breast Cancer 2022 Jun;22(4):e552-e557. Epub 2021 Dec 14 doi: 10.1016/j.clbc.2021.12.004. PMID: 34998709
Surgical follow-up and clinical presentation of 142 breast papillary lesions diagnosed by ultrasound-guided core-needle biopsy.
Rizzo M, Lund MJ, Oprea G, Schniederjan M, Wood WC, Mosunjac M
Ann Surg Oncol 2008 Apr;15(4):1040-7. Epub 2008 Jan 18 doi: 10.1245/s10434-007-9780-2. PMID: 18204989

Recent clinical studies

Etiology

A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real-world experience.
Li X, Wang H, Sun Z, Fan C, Jin F, Mao X
Cancer Med 2020 Oct;9(20):7751-7762. Epub 2020 Aug 21 doi: 10.1002/cam4.3308. PMID: 32822113Free PMC Article
Surgical excision of intraductal breast papilloma diagnosed on core biopsy.
Lu Q, Tan EY, Ho B, Chen JJ, Chan PM
ANZ J Surg 2012 Mar;82(3):168-72. Epub 2012 Jan 17 doi: 10.1111/j.1445-2197.2011.05969.x. PMID: 22510128

Diagnosis

A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real-world experience.
Li X, Wang H, Sun Z, Fan C, Jin F, Mao X
Cancer Med 2020 Oct;9(20):7751-7762. Epub 2020 Aug 21 doi: 10.1002/cam4.3308. PMID: 32822113Free PMC Article
Surgical excision of intraductal breast papilloma diagnosed on core biopsy.
Lu Q, Tan EY, Ho B, Chen JJ, Chan PM
ANZ J Surg 2012 Mar;82(3):168-72. Epub 2012 Jan 17 doi: 10.1111/j.1445-2197.2011.05969.x. PMID: 22510128
Intraductal breast papilloma in adolescent. Case report.
Onnis GL, Chiarelli SM, Dalla Palma P
Eur J Gynaecol Oncol 1983;4(3):211-3. PMID: 6401033

Prognosis

Surgical excision of intraductal breast papilloma diagnosed on core biopsy.
Lu Q, Tan EY, Ho B, Chen JJ, Chan PM
ANZ J Surg 2012 Mar;82(3):168-72. Epub 2012 Jan 17 doi: 10.1111/j.1445-2197.2011.05969.x. PMID: 22510128

Clinical prediction guides

A retrospective observational study of intraductal breast papilloma and its coexisting lesions: A real-world experience.
Li X, Wang H, Sun Z, Fan C, Jin F, Mao X
Cancer Med 2020 Oct;9(20):7751-7762. Epub 2020 Aug 21 doi: 10.1002/cam4.3308. PMID: 32822113Free PMC Article
Surgical excision of intraductal breast papilloma diagnosed on core biopsy.
Lu Q, Tan EY, Ho B, Chen JJ, Chan PM
ANZ J Surg 2012 Mar;82(3):168-72. Epub 2012 Jan 17 doi: 10.1111/j.1445-2197.2011.05969.x. PMID: 22510128

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