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Moderately reduced left ventricular ejection fraction

MedGen UID:
868397
Concept ID:
C4022791
Finding
Synonym: Moderately reduced ejection fraction
 
HPO: HP:0012665

Definition

A medium reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle, defined as a left ventricular ejection fraction of 30-39 percent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVModerately reduced left ventricular ejection fraction

Conditions with this feature

Dilated cardiomyopathy 1II
MedGen UID:
767563
Concept ID:
C3554649
Disease or Syndrome
Any familial isolated dilated cardiomyopathy in which the cause of the disease is a mutation in the CRYAB gene.

Professional guidelines

PubMed

Hamm W, Stülpnagel L, Vdovin N, Schmidt G, Rizas KD, Bauer A
Int J Cardiol 2017 Dec 15;249:1-5. doi: 10.1016/j.ijcard.2017.06.091. PMID: 29121716

Recent clinical studies

Etiology

Al Saadi T, Assaf Y, Farwati M, Turkmani K, Al-Mouakeh A, Shebli B, Khoja M, Essali A, Madmani ME
Cochrane Database Syst Rev 2021 Feb 3;(2)(2):CD008684. doi: 10.1002/14651858.CD008684.pub3. PMID: 35608922Free PMC Article
Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, Vollema EM, El Azzouzi I, Spitzer E, Delgado V, Bax JJ, Pibarot P, Clavel MA
J Am Coll Cardiol 2021 Jun 8;77(22):2796-2803. doi: 10.1016/j.jacc.2021.04.014. PMID: 34082909Free PMC Article
Hao G, Wang X, Chen Z, Zhang L, Zhang Y, Wei B, Zheng C, Kang Y, Jiang L, Zhu Z, Zhang J, Wang Z, Gao R; China Hypertension Survey Investigators
Eur J Heart Fail 2019 Nov;21(11):1329-1337. doi: 10.1002/ejhf.1629. PMID: 31746111
McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators
Eur J Heart Fail 2019 May;21(5):665-675. Epub 2019 Mar 21 doi: 10.1002/ejhf.1432. PMID: 30895697Free PMC Article
Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators
N Engl J Med 2009 Dec 17;361(25):2436-48. Epub 2009 Nov 17 doi: 10.1056/NEJMoa0908355. PMID: 19920054

Diagnosis

Stassen J, Ewe SH, Pio SM, Pibarot P, Redfors B, Leipsic J, Genereux P, Van Mieghem NM, Kuneman JH, Makkar R, Hahn RT, Playford D, Marsan NA, Delgado V, Ben-Yehuda O, Leon MB, Bax JJ
JACC Cardiovasc Imaging 2023 Jun;16(6):837-855. Epub 2023 Feb 8 doi: 10.1016/j.jcmg.2022.12.013. PMID: 36881428
Essayagh B, Sabbag A, Antoine C, Benfari G, Yang LT, Maalouf J, Asirvatham S, Michelena H, Enriquez-Sarano M
J Am Coll Cardiol 2020 Aug 11;76(6):637-649. doi: 10.1016/j.jacc.2020.06.029. PMID: 32762897
Hao G, Wang X, Chen Z, Zhang L, Zhang Y, Wei B, Zheng C, Kang Y, Jiang L, Zhu Z, Zhang J, Wang Z, Gao R; China Hypertension Survey Investigators
Eur J Heart Fail 2019 Nov;21(11):1329-1337. doi: 10.1002/ejhf.1629. PMID: 31746111
Ellingsen Ø, Halle M, Conraads V, Støylen A, Dalen H, Delagardelle C, Larsen AI, Hole T, Mezzani A, Van Craenenbroeck EM, Videm V, Beckers P, Christle JW, Winzer E, Mangner N, Woitek F, Höllriegel R, Pressler A, Monk-Hansen T, Snoer M, Feiereisen P, Valborgland T, Kjekshus J, Hambrecht R, Gielen S, Karlsen T, Prescott E, Linke A; SMARTEX Heart Failure Study (Study of Myocardial Recovery After Exercise Training in Heart Failure) Group
Circulation 2017 Feb 28;135(9):839-849. Epub 2017 Jan 12 doi: 10.1161/CIRCULATIONAHA.116.022924. PMID: 28082387Free PMC Article
Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T
Circulation 2007 Jun 19;115(24):3086-94. Epub 2007 Jun 4 doi: 10.1161/CIRCULATIONAHA.106.675041. PMID: 17548726

Therapy

Al Saadi T, Assaf Y, Farwati M, Turkmani K, Al-Mouakeh A, Shebli B, Khoja M, Essali A, Madmani ME
Cochrane Database Syst Rev 2021 Feb 3;(2)(2):CD008684. doi: 10.1002/14651858.CD008684.pub3. PMID: 35608922Free PMC Article
Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, Vollema EM, El Azzouzi I, Spitzer E, Delgado V, Bax JJ, Pibarot P, Clavel MA
J Am Coll Cardiol 2021 Jun 8;77(22):2796-2803. doi: 10.1016/j.jacc.2021.04.014. PMID: 34082909Free PMC Article
Hao G, Wang X, Chen Z, Zhang L, Zhang Y, Wei B, Zheng C, Kang Y, Jiang L, Zhu Z, Zhang J, Wang Z, Gao R; China Hypertension Survey Investigators
Eur J Heart Fail 2019 Nov;21(11):1329-1337. doi: 10.1002/ejhf.1629. PMID: 31746111
McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD; DAPA-HF Committees and Investigators
Eur J Heart Fail 2019 May;21(5):665-675. Epub 2019 Mar 21 doi: 10.1002/ejhf.1432. PMID: 30895697Free PMC Article
Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators
N Engl J Med 2009 Dec 17;361(25):2436-48. Epub 2009 Nov 17 doi: 10.1056/NEJMoa0908355. PMID: 19920054

Prognosis

Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, Vollema EM, El Azzouzi I, Spitzer E, Delgado V, Bax JJ, Pibarot P, Clavel MA
J Am Coll Cardiol 2021 Jun 8;77(22):2796-2803. doi: 10.1016/j.jacc.2021.04.014. PMID: 34082909Free PMC Article
Ito S, Miranda WR, Nkomo VT, Connolly HM, Pislaru SV, Greason KL, Pellikka PA, Lewis BR, Oh JK
J Am Coll Cardiol 2018 Mar 27;71(12):1313-1321. doi: 10.1016/j.jacc.2018.01.045. PMID: 29566814
Ellingsen Ø, Halle M, Conraads V, Støylen A, Dalen H, Delagardelle C, Larsen AI, Hole T, Mezzani A, Van Craenenbroeck EM, Videm V, Beckers P, Christle JW, Winzer E, Mangner N, Woitek F, Höllriegel R, Pressler A, Monk-Hansen T, Snoer M, Feiereisen P, Valborgland T, Kjekshus J, Hambrecht R, Gielen S, Karlsen T, Prescott E, Linke A; SMARTEX Heart Failure Study (Study of Myocardial Recovery After Exercise Training in Heart Failure) Group
Circulation 2017 Feb 28;135(9):839-849. Epub 2017 Jan 12 doi: 10.1161/CIRCULATIONAHA.116.022924. PMID: 28082387Free PMC Article
Anker SD, Comin Colet J, Filippatos G, Willenheimer R, Dickstein K, Drexler H, Lüscher TF, Bart B, Banasiak W, Niegowska J, Kirwan BA, Mori C, von Eisenhart Rothe B, Pocock SJ, Poole-Wilson PA, Ponikowski P; FAIR-HF Trial Investigators
N Engl J Med 2009 Dec 17;361(25):2436-48. Epub 2009 Nov 17 doi: 10.1056/NEJMoa0908355. PMID: 19920054
Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T
Circulation 2007 Jun 19;115(24):3086-94. Epub 2007 Jun 4 doi: 10.1161/CIRCULATIONAHA.106.675041. PMID: 17548726

Clinical prediction guides

Vetrovsky T, Siranec M, Frybova T, Gant I, Svobodova I, Linhart A, Parenica J, Miklikova M, Sujakova L, Pospisil D, Pelouch R, Odrazkova D, Parizek P, Precek J, Hutyra M, Taborsky M, Vesely J, Griva M, Semerad M, Bunc V, Hrabcova K, Vojkuvkova A, Svoboda M, Belohlavek J; WATCHFUL Investigators
Circulation 2024 Jan 16;149(3):177-188. Epub 2023 Nov 13 doi: 10.1161/CIRCULATIONAHA.123.067395. PMID: 37955615Free PMC Article
Stassen J, Ewe SH, Pio SM, Pibarot P, Redfors B, Leipsic J, Genereux P, Van Mieghem NM, Kuneman JH, Makkar R, Hahn RT, Playford D, Marsan NA, Delgado V, Ben-Yehuda O, Leon MB, Bax JJ
JACC Cardiovasc Imaging 2023 Jun;16(6):837-855. Epub 2023 Feb 8 doi: 10.1016/j.jcmg.2022.12.013. PMID: 36881428
Kosiborod MN, Jhund PS, Docherty KF, Diez M, Petrie MC, Verma S, Nicolau JC, Merkely B, Kitakaze M, DeMets DL, Inzucchi SE, Køber L, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, Bengtsson O, Lindholm D, Niklasson A, Sjöstrand M, Langkilde AM, McMurray JJV
Circulation 2020 Jan 14;141(2):90-99. Epub 2019 Nov 17 doi: 10.1161/CIRCULATIONAHA.119.044138. PMID: 31736335Free PMC Article
Heitner SB, Jacoby D, Lester SJ, Owens A, Wang A, Zhang D, Lambing J, Lee J, Semigran M, Sehnert AJ
Ann Intern Med 2019 Jun 4;170(11):741-748. Epub 2019 Apr 30 doi: 10.7326/M18-3016. PMID: 31035291
Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T
Circulation 2007 Jun 19;115(24):3086-94. Epub 2007 Jun 4 doi: 10.1161/CIRCULATIONAHA.106.675041. PMID: 17548726

Recent systematic reviews

Padhani ZA, Gangwani MK, Sadaf A, Hasan B, Colan S, Alvi N, Das JK
Cochrane Database Syst Rev 2023 Nov 17;11(11):CD011626. doi: 10.1002/14651858.CD011626.pub3. PMID: 37975597Free PMC Article
Zhao H, Liu Y, Liu M, Xu Y, Ling Q, Lin W, Zhang J, Yan Z, Ma J, Li W, Zhao Y, Yu P, Liu X, Wang J
Drugs 2023 Sep;83(14):1293-1307. Epub 2023 Aug 28 doi: 10.1007/s40265-023-01932-2. PMID: 37639180
Pappachan JM, Lahart IM, Viswanath AK, Borumandi F, Sodi R, Metzendorf MI, Bongaerts B
Cochrane Database Syst Rev 2023 Mar 8;3(3):CD013035. doi: 10.1002/14651858.CD013035.pub2. PMID: 36883976Free PMC Article
Al Saadi T, Assaf Y, Farwati M, Turkmani K, Al-Mouakeh A, Shebli B, Khoja M, Essali A, Madmani ME
Cochrane Database Syst Rev 2021 Feb 3;(2)(2):CD008684. doi: 10.1002/14651858.CD008684.pub3. PMID: 35608922Free PMC Article
Khan MS, Khan F, Fonarow GC, Sreenivasan J, Greene SJ, Khan SU, Usman MS, Vaduganathan M, Fudim M, Anker SD, Butler J
Eur J Heart Fail 2021 Sep;23(9):1468-1476. Epub 2021 Jul 8 doi: 10.1002/ejhf.2278. PMID: 34173307

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