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Mildly reduced left ventricular ejection fraction

MedGen UID:
868399
Concept ID:
C4022793
Finding
Synonym: Mildly reduced ejection fraction
 
HPO: HP:0012663

Definition

A small reduction in the fraction of blood pumped from the left ventricle with each cardiac cycle. The normal range in adults is at least 50 percent, and a mild reduction is defined as 40-49 percent. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMildly reduced left ventricular ejection fraction

Conditions with this feature

Short QT syndrome type 3
MedGen UID:
400662
Concept ID:
C1865018
Disease or Syndrome
Short QT syndrome is a cardiac channelopathy associated with a predisposition to atrial fibrillation and sudden cardiac death. Patients have a structurally normal heart, but electrocardiography (ECG) exhibits abbreviated QTc (Bazett's corrected QT) intervals of less than 360 ms (summary by Moreno et al., 2015). For a discussion of genetic heterogeneity of short QT syndrome, see SQT1 (609620).
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5
MedGen UID:
1648331
Concept ID:
C4748184
Disease or Syndrome

Professional guidelines

PubMed

Porcel JM
Semin Respir Crit Care Med 2023 Aug;44(4):477-490. Epub 2023 Jun 1 doi: 10.1055/s-0043-1769096. PMID: 37263288
Chen YJ, Chien CS, Chiang CE, Chen CH, Cheng HM
Int J Mol Sci 2021 Jun 21;22(12) doi: 10.3390/ijms22126617. PMID: 34205587Free PMC Article

Recent clinical studies

Etiology

Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators
N Engl J Med 2024 Oct 24;391(16):1475-1485. Epub 2024 Sep 1 doi: 10.1056/NEJMoa2407107. PMID: 39225278
Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, McMurray JJV, Solomon SD
Lancet 2022 Sep 3;400(10354):757-767. Epub 2022 Aug 27 doi: 10.1016/S0140-6736(22)01429-5. PMID: 36041474
Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O'Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderäng U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM; DELIVER Trial Committees and Investigators
N Engl J Med 2022 Sep 22;387(12):1089-1098. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2206286. PMID: 36027570
Savarese G, Stolfo D, Sinagra G, Lund LH
Nat Rev Cardiol 2022 Feb;19(2):100-116. Epub 2021 Sep 6 doi: 10.1038/s41569-021-00605-5. PMID: 34489589Free PMC Article
Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S
Eur J Heart Fail 2021 Mar;23(3):352-380. Epub 2021 Mar 3 doi: 10.1002/ejhf.2115. PMID: 33605000

Diagnosis

Butler J, Abildstrøm SZ, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Verma S, Abhayaratna WP, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Núñez J, Perna E, Schou M, Senni M, van der Meer P, von Lewinski D, Wolf D, Altschul RL, Rasmussen S, Kosiborod MN
J Am Coll Cardiol 2023 Nov 28;82(22):2087-2096. Epub 2023 Oct 8 doi: 10.1016/j.jacc.2023.09.811. PMID: 37993201Free PMC Article
Riccardi M, Sammartino AM, Piepoli M, Adamo M, Pagnesi M, Rosano G, Metra M, von Haehling S, Tomasoni D
ESC Heart Fail 2022 Dec;9(6):3667-3693. doi: 10.1002/ehf2.14257. PMID: 36546712Free PMC Article
Peikert A, Martinez FA, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Shah SJ, Katova T, Merkely B, Vardeny O, Wilderäng U, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
Circ Heart Fail 2022 Oct;15(10):e010080. Epub 2022 Aug 27 doi: 10.1161/CIRCHEARTFAILURE.122.010080. PMID: 36029467
Mullens W, Martens P, Testani JM, Tang WHW, Skouri H, Verbrugge FH, Fudim M, Iacoviello M, Franke J, Flammer AJ, Palazzuoli A, Barragan PM, Thum T, Marcos MC, Miró Ò, Rossignol P, Metra M, Lassus J, Orso F, Jankowska EA, Chioncel O, Milicic D, Hill L, Seferovic P, Rosano G, Coats A, Damman K
Eur J Heart Fail 2022 Apr;24(4):603-619. Epub 2022 Mar 27 doi: 10.1002/ejhf.2471. PMID: 35239201
Savarese G, Stolfo D, Sinagra G, Lund LH
Nat Rev Cardiol 2022 Feb;19(2):100-116. Epub 2021 Sep 6 doi: 10.1038/s41569-021-00605-5. PMID: 34489589Free PMC Article

Therapy

Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators
N Engl J Med 2024 Oct 24;391(16):1475-1485. Epub 2024 Sep 1 doi: 10.1056/NEJMoa2407107. PMID: 39225278
Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, McMurray JJV, Solomon SD
Lancet 2022 Sep 3;400(10354):757-767. Epub 2022 Aug 27 doi: 10.1016/S0140-6736(22)01429-5. PMID: 36041474
Peikert A, Martinez FA, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Shah SJ, Katova T, Merkely B, Vardeny O, Wilderäng U, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
Circ Heart Fail 2022 Oct;15(10):e010080. Epub 2022 Aug 27 doi: 10.1161/CIRCHEARTFAILURE.122.010080. PMID: 36029467
Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, Borleffs CJW, Comin-Colet J, Dobreanu D, Drozdz J, Fang JC, Alcocer-Gamba MA, Al Habeeb W, Han Y, Cabrera Honorio JW, Janssens SP, Katova T, Kitakaze M, Merkely B, O'Meara E, Saraiva JFK, Tereshchenko SN, Thierer J, Vaduganathan M, Vardeny O, Verma S, Pham VN, Wilderäng U, Zaozerska N, Bachus E, Lindholm D, Petersson M, Langkilde AM; DELIVER Trial Committees and Investigators
N Engl J Med 2022 Sep 22;387(12):1089-1098. Epub 2022 Aug 27 doi: 10.1056/NEJMoa2206286. PMID: 36027570
Savarese G, Stolfo D, Sinagra G, Lund LH
Nat Rev Cardiol 2022 Feb;19(2):100-116. Epub 2021 Sep 6 doi: 10.1038/s41569-021-00605-5. PMID: 34489589Free PMC Article

Prognosis

Solomon SD, McMurray JJV, Vaduganathan M, Claggett B, Jhund PS, Desai AS, Henderson AD, Lam CSP, Pitt B, Senni M, Shah SJ, Voors AA, Zannad F, Abidin IZ, Alcocer-Gamba MA, Atherton JJ, Bauersachs J, Chang-Sheng M, Chiang CE, Chioncel O, Chopra V, Comin-Colet J, Filippatos G, Fonseca C, Gajos G, Goland S, Goncalvesova E, Kang S, Katova T, Kosiborod MN, Latkovskis G, Lee AP, Linssen GCM, Llamas-Esperón G, Mareev V, Martinez FA, Melenovský V, Merkely B, Nodari S, Petrie MC, Saldarriaga CI, Saraiva JFK, Sato N, Schou M, Sharma K, Troughton R, Udell JA, Ukkonen H, Vardeny O, Verma S, von Lewinski D, Voronkov L, Yilmaz MB, Zieroth S, Lay-Flurrie J, van Gameren I, Amarante F, Kolkhof P, Viswanathan P; FINEARTS-HF Committees and Investigators
N Engl J Med 2024 Oct 24;391(16):1475-1485. Epub 2024 Sep 1 doi: 10.1056/NEJMoa2407107. PMID: 39225278
Wang Y, Gao T, Meng C, Li S, Bi L, Geng Y, Zhang P
Eur J Med Res 2022 Dec 29;27(1):314. doi: 10.1186/s40001-022-00945-z. PMID: 36581880Free PMC Article
Riccardi M, Sammartino AM, Piepoli M, Adamo M, Pagnesi M, Rosano G, Metra M, von Haehling S, Tomasoni D
ESC Heart Fail 2022 Dec;9(6):3667-3693. doi: 10.1002/ehf2.14257. PMID: 36546712Free PMC Article
Savarese G, Stolfo D, Sinagra G, Lund LH
Nat Rev Cardiol 2022 Feb;19(2):100-116. Epub 2021 Sep 6 doi: 10.1038/s41569-021-00605-5. PMID: 34489589Free PMC Article
Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, Anker SD, Atherton J, Böhm M, Butler J, Drazner MH, Michael Felker G, Filippatos G, Fiuzat M, Fonarow GC, Gomez-Mesa JE, Heidenreich P, Imamura T, Jankowska EA, Januzzi J, Khazanie P, Kinugawa K, Lam CSP, Matsue Y, Metra M, Ohtani T, Francesco Piepoli M, Ponikowski P, Rosano GMC, Sakata Y, Seferović P, Starling RC, Teerlink JR, Vardeny O, Yamamoto K, Yancy C, Zhang J, Zieroth S
Eur J Heart Fail 2021 Mar;23(3):352-380. Epub 2021 Mar 3 doi: 10.1002/ejhf.2115. PMID: 33605000

Clinical prediction guides

Butler J, Abildstrøm SZ, Borlaug BA, Davies MJ, Kitzman DW, Petrie MC, Shah SJ, Verma S, Abhayaratna WP, Chopra V, Ezekowitz JA, Fu M, Ito H, Lelonek M, Núñez J, Perna E, Schou M, Senni M, van der Meer P, von Lewinski D, Wolf D, Altschul RL, Rasmussen S, Kosiborod MN
J Am Coll Cardiol 2023 Nov 28;82(22):2087-2096. Epub 2023 Oct 8 doi: 10.1016/j.jacc.2023.09.811. PMID: 37993201Free PMC Article
Butt JH, Kondo T, Jhund PS, Comin-Colet J, de Boer RA, Desai AS, Hernandez AF, Inzucchi SE, Janssens SP, Kosiborod MN, Lam CSP, Langkilde AM, Lindholm D, Martinez F, Petersson M, Shah SJ, Thierer J, Vaduganathan M, Verma S, Wilderäng U, Claggett BC, Solomon SD, McMurray JJV
J Am Coll Cardiol 2022 Nov 1;80(18):1705-1717. Epub 2022 Aug 27 doi: 10.1016/j.jacc.2022.08.718. PMID: 36041668
Vaduganathan M, Docherty KF, Claggett BL, Jhund PS, de Boer RA, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, McMurray JJV, Solomon SD
Lancet 2022 Sep 3;400(10354):757-767. Epub 2022 Aug 27 doi: 10.1016/S0140-6736(22)01429-5. PMID: 36041474
Peikert A, Martinez FA, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Shah SJ, Katova T, Merkely B, Vardeny O, Wilderäng U, Lindholm D, Petersson M, Langkilde AM, McMurray JJV, Solomon SD
Circ Heart Fail 2022 Oct;15(10):e010080. Epub 2022 Aug 27 doi: 10.1161/CIRCHEARTFAILURE.122.010080. PMID: 36029467
Pieske B, Wachter R, Shah SJ, Baldridge A, Szeczoedy P, Ibram G, Shi V, Zhao Z, Cowie MR; PARALLAX Investigators and Committee members
JAMA 2021 Nov 16;326(19):1919-1929. doi: 10.1001/jama.2021.18463. PMID: 34783839Free PMC Article

Recent systematic reviews

Hoek AG, Dal Canto E, Wenker E, Bindraban N, Handoko ML, Elders PJM, Beulens JWJ
Diabetologia 2024 Apr;67(4):574-601. Epub 2024 Feb 9 doi: 10.1007/s00125-023-06068-2. PMID: 38334818Free PMC Article
Zafeiropoulos S, Farmakis IT, Milioglou I, Doundoulakis I, Gorodeski EZ, Konstantinides SV, Cooper L, Zanos S, Stavrakis S, Giamouzis G, Butler J, Giannakoulas G
JACC Heart Fail 2024 Apr;12(4):616-627. Epub 2023 Aug 30 doi: 10.1016/j.jchf.2023.07.014. PMID: 37656079
Yu GI, Kim TH, Cho YH, Bae JS, Ahn JH, Jang JY, Park YW, Kwak CH
Clin Cardiol 2023 Jul;46(7):713-720. Epub 2023 May 5 doi: 10.1002/clc.24028. PMID: 37144691Free PMC Article
Wang Y, Gao T, Meng C, Li S, Bi L, Geng Y, Zhang P
Eur J Med Res 2022 Dec 29;27(1):314. doi: 10.1186/s40001-022-00945-z. PMID: 36581880Free PMC Article
Aimo A, Merlo M, Porcari A, Georgiopoulos G, Pagura L, Vergaro G, Sinagra G, Emdin M, Rapezzi C
Eur J Heart Fail 2022 Dec;24(12):2342-2351. Epub 2022 May 16 doi: 10.1002/ejhf.2532. PMID: 35509173Free PMC Article

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