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Abnormal total iron binding capacity

MedGen UID:
1771764
•Concept ID:
C0236159
•
Finding
HPO: HP:0033212

Definition

Any deviation from the normal total-iron binding capacity, which measures how much serum iron is bound if an excess of radioactive iron is added. [from HPO]

Professional guidelines

PubMed

Cascade testing of primary care blood samples with hyperferritinaemia identifies subjects with iron overload and porphyria cutanea tarda.
Baddams EL, Degg T, Barth JH
Ann Clin Biochem 2014 Jul;51(Pt 4):499-502. Epub 2013 Sep 30 doi: 10.1177/0004563213504906. PMID: 24081184

Recent clinical studies

Etiology

HEPCIDIN AND IRON BIOMARKERS MODULATED IN HEMODIALYSIS PATIENTS.
Mohammed M, Sarhat E, Marbut M
Georgian Med News 2023 Nov;(344):101-105. PMID: 38236107
Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis.
Chuang PH, Tsai KF, Wang IK, Huang YC, Huang LM, Liu SH, Weng CH, Huang WH, Hsu CW, Lee WC, Yen TH
Int J Environ Res Public Health 2022 Mar 24;19(7) doi: 10.3390/ijerph19073885. PMID: 35409569Free PMC Article
Total iron binding capacity (TIBC) is a potential biomarker of left ventricular remodelling for patients with iron deficiency anaemia.
Chen Y, Wan J, Xia H, Li Y, Xu Y, Lin H, Iftikhar H
BMC Cardiovasc Disord 2020 Jan 8;20(1):4. doi: 10.1186/s12872-019-01320-3. PMID: 31914941Free PMC Article
Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.
Letner D, Peloquin J, Durand J, Rutherford A, Yajnik V, Khalili H, Garber J
Dig Dis Sci 2015 Dec;60(12):3735-42. Epub 2015 Jul 15 doi: 10.1007/s10620-015-3791-9. PMID: 26173503
Helicobacter pylori and anemia with pregnancy.
Nashaat EH, Mansour GM
Arch Gynecol Obstet 2014 Jun;289(6):1197-202. Epub 2013 Dec 28 doi: 10.1007/s00404-013-3138-8. PMID: 24374855

Diagnosis

Inherited microcytic anemias.
Cappellini MD, Russo R, Andolfo I, Iolascon A
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):465-470. doi: 10.1182/hematology.2020000158. PMID: 33275715Free PMC Article
How we diagnose and treat iron deficiency anemia.
Auerbach M, Adamson JW
Am J Hematol 2016 Jan;91(1):31-8. Epub 2015 Nov 17 doi: 10.1002/ajh.24201. PMID: 26408108
Elevated Total Iron-Binding Capacity Is Associated with an Increased Risk of Celiac Disease.
Letner D, Peloquin J, Durand J, Rutherford A, Yajnik V, Khalili H, Garber J
Dig Dis Sci 2015 Dec;60(12):3735-42. Epub 2015 Jul 15 doi: 10.1007/s10620-015-3791-9. PMID: 26173503
Evaluation of microcytosis.
Van Vranken M
Am Fam Physician 2010 Nov 1;82(9):1117-22. PMID: 21121557
Late-onset Rothmund-Thomson syndrome.
Kumar P, Sharma PK, Gautam RK, Jain RK, Kar HK
Int J Dermatol 2007 May;46(5):492-3. doi: 10.1111/j.1365-4632.2007.03248.x. PMID: 17472679

Therapy

Effects of early parenteral iron combined erythropoietin in preterm infants: A randomized controlled trial.
Qiao L, Tang Q, Zhu W, Zhang H, Zhu Y, Wang H
Medicine (Baltimore) 2017 Mar;96(9):e5795. doi: 10.1097/MD.0000000000005795. PMID: 28248850Free PMC Article
Influence of diet and supplements on iron status after gastric bypass surgery.
Mischler RA, Armah SM, Wright BN, Mattar SG, Rosen AD, Gletsu-Miller N
Surg Obes Relat Dis 2016 Mar-Apr;12(3):651-658. Epub 2015 Sep 21 doi: 10.1016/j.soard.2015.09.007. PMID: 26806728
How we diagnose and treat iron deficiency anemia.
Auerbach M, Adamson JW
Am J Hematol 2016 Jan;91(1):31-8. Epub 2015 Nov 17 doi: 10.1002/ajh.24201. PMID: 26408108
Helicobacter pylori and anemia with pregnancy.
Nashaat EH, Mansour GM
Arch Gynecol Obstet 2014 Jun;289(6):1197-202. Epub 2013 Dec 28 doi: 10.1007/s00404-013-3138-8. PMID: 24374855
Oral discomfort at menopause.
Wardrop RW, Hailes J, Burger H, Reade PC
Oral Surg Oral Med Oral Pathol 1989 May;67(5):535-40. doi: 10.1016/0030-4220(89)90269-7. PMID: 2497421

Prognosis

Total iron binding capacity (TIBC) is a potential biomarker of left ventricular remodelling for patients with iron deficiency anaemia.
Chen Y, Wan J, Xia H, Li Y, Xu Y, Lin H, Iftikhar H
BMC Cardiovasc Disord 2020 Jan 8;20(1):4. doi: 10.1186/s12872-019-01320-3. PMID: 31914941Free PMC Article
Alterations in the Iron Homeostasis Network of Hepatocytes Caused by Hepatitis B Virus.
Hou SW, Wang ZF, Guan SH, Yang K, Wang Q, Chen LW, Zhang H, Wang X, Duan YL, Pan ZL
Clin Lab 2019 Apr 1;65(4) doi: 10.7754/Clin.Lab.2018.180914. PMID: 30969090
Enhanced plasma protein carbonylation in patients with myelodysplastic syndromes.
Hlaváčková A, Štikarová J, Pimková K, Chrastinová L, Májek P, Kotlín R, Čermák J, Suttnar J, Dyr JE
Free Radic Biol Med 2017 Jul;108:1-7. Epub 2017 Mar 12 doi: 10.1016/j.freeradbiomed.2017.03.007. PMID: 28300669
Influence of diet and supplements on iron status after gastric bypass surgery.
Mischler RA, Armah SM, Wright BN, Mattar SG, Rosen AD, Gletsu-Miller N
Surg Obes Relat Dis 2016 Mar-Apr;12(3):651-658. Epub 2015 Sep 21 doi: 10.1016/j.soard.2015.09.007. PMID: 26806728
Iron deficiency and hematological changes in adult patients after Fontan operation.
Tomkiewicz-Pajak L, Plazak W, Kolcz J, Pajak J, Kopec G, Dluzniewska N, Olszowska M, Moryl-Bujakowska A, Podolec P
J Cardiol 2014 Nov;64(5):384-9. Epub 2014 Mar 31 doi: 10.1016/j.jjcc.2014.02.021. PMID: 24698006

Clinical prediction guides

Evaluation of Serum Iron Profile in Patients with Pulmonary Tuberculosis.
Shamim M, Rahim MA, Hasan MN, Rahman MA
Mymensingh Med J 2023 Oct;32(4):1064-1072. PMID: 37777903
Blood Aluminum Levels in Patients with Hemodialysis and Peritoneal Dialysis.
Chuang PH, Tsai KF, Wang IK, Huang YC, Huang LM, Liu SH, Weng CH, Huang WH, Hsu CW, Lee WC, Yen TH
Int J Environ Res Public Health 2022 Mar 24;19(7) doi: 10.3390/ijerph19073885. PMID: 35409569Free PMC Article
CLINICAL SIGNIFICANCE AND CORRELATION ANALYSIS OF SERUM FERRITIN IN PATIENTS WITH HEPATIC ALVEOLAR ECHINOCOCCOSIS.
Wang Q, Wang ZX, Wang HJ, Ren L, Kang YL, Pan SY, Sami MW, Fan HN, Wang H
J Parasitol 2022 Mar 1;108(2):159-165. doi: 10.1645/19-69. PMID: 35353187
Enhanced plasma protein carbonylation in patients with myelodysplastic syndromes.
Hlaváčková A, Štikarová J, Pimková K, Chrastinová L, Májek P, Kotlín R, Čermák J, Suttnar J, Dyr JE
Free Radic Biol Med 2017 Jul;108:1-7. Epub 2017 Mar 12 doi: 10.1016/j.freeradbiomed.2017.03.007. PMID: 28300669
Late-onset Rothmund-Thomson syndrome.
Kumar P, Sharma PK, Gautam RK, Jain RK, Kar HK
Int J Dermatol 2007 May;46(5):492-3. doi: 10.1111/j.1365-4632.2007.03248.x. PMID: 17472679

Recent systematic reviews

Aberrations of biochemical indicators in amyotrophic lateral sclerosis: a systematic review and meta-analysis.
Cheng Y, Chen Y, Shang H
Transl Neurodegener 2021 Jan 8;10(1):3. doi: 10.1186/s40035-020-00228-9. PMID: 33419478Free PMC Article

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