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Increased circulating ceruloplasmin concentration

MedGen UID:
1750791
•Concept ID:
C5421639
•
Finding
HPO: HP:0033145

Definition

Elevated concentration of ceruloplasmin in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased circulating ceruloplasmin concentration

Professional guidelines

PubMed

Changes in micronutrient concentrations following anti-inflammatory treatment in patients with gastrointestinal cancer.
McMillan DC, Sattar N, Talwar D, O'Reilly DS, McArdle CS
Nutrition 2000 Jun;16(6):425-8. doi: 10.1016/s0899-9007(00)00270-7. PMID: 10869897
CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440

Recent clinical studies

Etiology

Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.
Zwart SR, Auñón-Chancellor SM, Heer M, Melin MM, Smith SM
J Appl Physiol (1985) 2022 May 1;132(5):1232-1239. Epub 2022 Apr 7 doi: 10.1152/japplphysiol.00024.2022. PMID: 35389755Free PMC Article
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
Nutrients 2021 May 31;13(6) doi: 10.3390/nu13061898. PMID: 34072977Free PMC Article
Circulating ceruloplasmin, ceruloplasmin-associated genes and the incidence of venous thromboembolism in the Atherosclerosis Risk in Communities study.
Arenas de Larriva AP, Alonso A, Norby FL, Roetker NS, Folsom AR
J Thromb Haemost 2019 May;17(5):818-826. Epub 2019 Mar 18 doi: 10.1111/jth.14420. PMID: 30803124Free PMC Article
Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.
Arenas de Larriva AP, Norby FL, Chen LY, Soliman EZ, Hoogeveen RC, Arking DE, Loehr LR, Alonso A
Int J Cardiol 2017 Aug 15;241:223-228. Epub 2017 Apr 6 doi: 10.1016/j.ijcard.2017.04.005. PMID: 28427851Free PMC Article
A comparison of liver protein induction in postmenopausal women during oral and percutaneous oestrogen replacement therapy.
Holst J, Cajander S, Carlström K, Damber MG, von Schoultz B
Br J Obstet Gynaecol 1983 Apr;90(4):355-60. doi: 10.1111/j.1471-0528.1983.tb08923.x. PMID: 6682335

Diagnosis

BIOMARKERS OF DISEASE ACTIVITY IN SYSTEMIC SCLEROSIS.
Pawlik KK, Bohdziewicz A, Chrabąszcz M, Stochmal A, Sikora M, Alda-Malicka R, Czuwara J, Rudnicka L
Wiad Lek 2020;73(10):2300-2305. PMID: 33310967
Wilson disease.
Guindi M
Semin Diagn Pathol 2019 Nov;36(6):415-422. Epub 2019 Jul 25 doi: 10.1053/j.semdp.2019.07.008. PMID: 31421978
Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.
Arenas de Larriva AP, Norby FL, Chen LY, Soliman EZ, Hoogeveen RC, Arking DE, Loehr LR, Alonso A
Int J Cardiol 2017 Aug 15;241:223-228. Epub 2017 Apr 6 doi: 10.1016/j.ijcard.2017.04.005. PMID: 28427851Free PMC Article
Crosstalk between inflammation, iron metabolism and endothelial function in Behçet's disease.
Oliveira R, Napoleão P, Banha J, Paixão E, Bettencourt A, da Silva BM, Pereira D, Barcelos F, Teixeira A, Patto JV, Viegas-Crespo AM, Costa L
Clin Hemorheol Microcirc 2014;56(2):175-85. doi: 10.3233/CH-131725. PMID: 23619201
Assessment of copper status in pregnancy by means of determining the specific oxidase activity of ceruloplasmin.
Louro MO, Cocho JA, Tutor JC
Clin Chim Acta 2001 Oct;312(1-2):123-7. doi: 10.1016/s0009-8981(01)00607-6. PMID: 11580917

Therapy

Albumin, oral contraceptives, and venous thromboembolism risk in astronauts.
Zwart SR, Auñón-Chancellor SM, Heer M, Melin MM, Smith SM
J Appl Physiol (1985) 2022 May 1;132(5):1232-1239. Epub 2022 Apr 7 doi: 10.1152/japplphysiol.00024.2022. PMID: 35389755Free PMC Article
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
Nutrients 2021 May 31;13(6) doi: 10.3390/nu13061898. PMID: 34072977Free PMC Article
Transcuprein is a macroglobulin regulated by copper and iron availability.
Liu N, Lo LS, Askary SH, Jones L, Kidane TZ, Trang T, Nguyen M, Goforth J, Chu YH, Vivas E, Tsai M, Westbrook T, Linder MC
J Nutr Biochem 2007 Sep;18(9):597-608. Epub 2007 Mar 23 doi: 10.1016/j.jnutbio.2006.11.005. PMID: 17363239Free PMC Article
CSF copper concentrations, blood-brain barrier function, and coeruloplasmin synthesis during the treatment of Wilson's disease.
Stuerenburg HJ
J Neural Transm (Vienna) 2000;107(3):321-9. doi: 10.1007/s007020050026. PMID: 10821440
Effects of low-copper diets on human immune response.
Kelley DS, Daudu PA, Taylor PC, Mackey BE, Turnlund JR
Am J Clin Nutr 1995 Aug;62(2):412-6. doi: 10.1093/ajcn/62.2.412. PMID: 7625350

Prognosis

Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
Nutrients 2021 May 31;13(6) doi: 10.3390/nu13061898. PMID: 34072977Free PMC Article
Circulating ceruloplasmin, ceruloplasmin-associated genes and the incidence of venous thromboembolism in the Atherosclerosis Risk in Communities study.
Arenas de Larriva AP, Alonso A, Norby FL, Roetker NS, Folsom AR
J Thromb Haemost 2019 May;17(5):818-826. Epub 2019 Mar 18 doi: 10.1111/jth.14420. PMID: 30803124Free PMC Article
Circulating ceruloplasmin, ceruloplasmin-associated genes, and the incidence of atrial fibrillation in the atherosclerosis risk in communities study.
Arenas de Larriva AP, Norby FL, Chen LY, Soliman EZ, Hoogeveen RC, Arking DE, Loehr LR, Alonso A
Int J Cardiol 2017 Aug 15;241:223-228. Epub 2017 Apr 6 doi: 10.1016/j.ijcard.2017.04.005. PMID: 28427851Free PMC Article
Plasma hepcidin correlates positively with interleukin-6 in patients undergoing pulmonary endarterectomy.
Maruna P, Vokurka M, Lindner J
Physiol Res 2011;60(3):493-502. Epub 2011 Mar 14 doi: 10.33549/physiolres.931996. PMID: 21401300
Acute phase proteins in atherosclerosis (acute coronary syndrome).
Correale M, Brunetti ND, De Gennaro L, Di Biase M
Cardiovasc Hematol Agents Med Chem 2008 Oct;6(4):272-7. doi: 10.2174/187152508785909537. PMID: 18855639

Clinical prediction guides

Residual feed intake in peripartal dairy cows is associated with differences in milk fat yield, ruminal bacteria, biopolymer hydrolyzing enzymes, and circulating biomarkers of immunometabolism.
Elolimy AA, Liang Y, Wilachai K, Alharthi AS, Paengkoum P, Trevisi E, Loor JJ
J Dairy Sci 2022 Aug;105(8):6654-6669. Epub 2022 Jul 13 doi: 10.3168/jds.2021-21274. PMID: 35840400
Relation of Serum Copper Status to Survival in COVID-19.
Hackler J, Heller RA, Sun Q, Schwarzer M, Diegmann J, Bachmann M, Moghaddam A, Schomburg L
Nutrients 2021 May 31;13(6) doi: 10.3390/nu13061898. PMID: 34072977Free PMC Article
Circulating ceruloplasmin, ceruloplasmin-associated genes and the incidence of venous thromboembolism in the Atherosclerosis Risk in Communities study.
Arenas de Larriva AP, Alonso A, Norby FL, Roetker NS, Folsom AR
J Thromb Haemost 2019 May;17(5):818-826. Epub 2019 Mar 18 doi: 10.1111/jth.14420. PMID: 30803124Free PMC Article
Long-term donors versus non-donor men: Iron metabolism and the atherosclerotic process.
Riško P, Pláteník J, Buchal R, Potočková J, Kraml PJ
Atherosclerosis 2018 May;272:14-20. Epub 2018 Mar 3 doi: 10.1016/j.atherosclerosis.2018.03.009. PMID: 29544084
A comparison of liver protein induction in postmenopausal women during oral and percutaneous oestrogen replacement therapy.
Holst J, Cajander S, Carlström K, Damber MG, von Schoultz B
Br J Obstet Gynaecol 1983 Apr;90(4):355-60. doi: 10.1111/j.1471-0528.1983.tb08923.x. PMID: 6682335

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