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Colorectal Poorly Cohesive Adenocarcinoma

MedGen UID:
1723389
•Concept ID:
C5419794
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the colorectal mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Poorly Cohesive Adenocarcinoma

Recent clinical studies

Etiology

Gastric cancer: new genetic developments.
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459
p53 mutation in gastric cancer: a genetic model for carcinogenesis is common to gastric and colorectal cancer.
Uchino S, Noguchi M, Ochiai A, Saito T, Kobayashi M, Hirohashi S
Int J Cancer 1993 Jul 9;54(5):759-64. doi: 10.1002/ijc.2910540509. PMID: 8392033

Diagnosis

POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation.
Pancsa T, Vasas B, Melegh Z, Tóth E, Torday L, Sejben A
J Gastrointest Cancer 2024 Jun;55(2):961-964. Epub 2024 Jan 4 doi: 10.1007/s12029-023-01004-4. PMID: 38175383
Morphologic Heterogeneity of Carcinoma with Signet Ring Cell Features at Different Primary Sites.
Dahoud W, Gullo I, Imam R, Tang LH
Pathobiology 2024;91(4):279-287. Epub 2023 Dec 23 doi: 10.1159/000535941. PMID: 38142679
Gastric cancer: new genetic developments.
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459

Therapy

Gastric cancer: new genetic developments.
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459

Prognosis

POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation.
Pancsa T, Vasas B, Melegh Z, Tóth E, Torday L, Sejben A
J Gastrointest Cancer 2024 Jun;55(2):961-964. Epub 2024 Jan 4 doi: 10.1007/s12029-023-01004-4. PMID: 38175383
Molecular Landscape and Association With Crohn Disease of Poorly Cohesive Carcinomas of the Nonampullary Small Bowel.
Tedaldi G, Guerini C, Angeli D, Furlan D, Libera L, Lenti MV, Grillo F, Fassan M, Solcia E, Sessa F, Paulli M, Di Sabatino A, Ulivi P, Vanoli A
Am J Clin Pathol 2023 Apr 4;159(4):315-324. doi: 10.1093/ajcp/aqac161. PMID: 36812376Free PMC Article
Gastric cancer: new genetic developments.
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459

Clinical prediction guides

POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation.
Pancsa T, Vasas B, Melegh Z, Tóth E, Torday L, Sejben A
J Gastrointest Cancer 2024 Jun;55(2):961-964. Epub 2024 Jan 4 doi: 10.1007/s12029-023-01004-4. PMID: 38175383
Morphologic Heterogeneity of Carcinoma with Signet Ring Cell Features at Different Primary Sites.
Dahoud W, Gullo I, Imam R, Tang LH
Pathobiology 2024;91(4):279-287. Epub 2023 Dec 23 doi: 10.1159/000535941. PMID: 38142679

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