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Metastatic Small Intestinal Neuroendocrine Carcinoma

MedGen UID:
1660492
•Concept ID:
C4744987
•
Neoplastic Process

Definition

A small intestinal neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.
Bazarbashi S, Aseafan M, Elgazzar T, Alkhayat M, Alghabban A, Abdelgawad MI, Alshamsan B, Alshibany A, Elhassan T, Aljubran A, Alzahrani A, Alhindi H, Raef H
BMC Endocr Disord 2023 Apr 7;23(1):74. doi: 10.1186/s12902-023-01326-1. PMID: 37029347Free PMC Article
Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Recent clinical studies

Etiology

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Incidence, survival and stage at diagnosis of small intestinal neuroendocrine tumours in Queensland, Australia, 2001-2015.
Wyld D, Moore J, Tran N, Youl P
Asia Pac J Clin Oncol 2021 Aug;17(4):350-358. Epub 2021 Feb 10 doi: 10.1111/ajco.13503. PMID: 33567164
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602

Diagnosis

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Incidence, survival and stage at diagnosis of small intestinal neuroendocrine tumours in Queensland, Australia, 2001-2015.
Wyld D, Moore J, Tran N, Youl P
Asia Pac J Clin Oncol 2021 Aug;17(4):350-358. Epub 2021 Feb 10 doi: 10.1111/ajco.13503. PMID: 33567164
Primary small intestinal neuroendocrine tumors are highly prevalent and often multiple before metastatic disease develops.
Eriksson J, Norlén O, Ögren M, Garmo H, Ihre-Lundgren C, Hellman P
Scand J Surg 2021 Mar;110(1):44-50. Epub 2019 Oct 7 doi: 10.1177/1457496919874484. PMID: 31587594
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Small-cell neuroendocrine carcinoma of the ileum: case report and literature review.
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article

Therapy

Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Long-Term Survival with Long-Acting Somatostatin Analogues Plus Aggressive Cytoreductive Surgery in Patients with Metastatic Neuroendocrine Carcinoma.
Deutsch GB, Lee JH, Bilchik AJ
J Am Coll Surg 2015 Jul;221(1):26-36. Epub 2015 Apr 8 doi: 10.1016/j.jamcollsurg.2015.03.055. PMID: 26027502
Are G3 ENETS neuroendocrine neoplasms heterogeneous?
Vélayoudom-Céphise FL, Duvillard P, Foucan L, Hadoux J, Chougnet CN, Leboulleux S, Malka D, Guigay J, Goere D, Debaere T, Caramella C, Schlumberger M, Planchard D, Elias D, Ducreux M, Scoazec JY, Baudin E
Endocr Relat Cancer 2013 Oct;20(5):649-57. Epub 2013 Aug 19 doi: 10.1530/ERC-13-0027. PMID: 23845449
Treatment of metastatic disease in patients with neuroendocrine tumors.
Niederhuber JE, Fojo T
Surg Oncol Clin N Am 2006 Jul;15(3):511-33, viii. doi: 10.1016/j.soc.2006.05.004. PMID: 16882495

Prognosis

Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Zhu J, Xiao W, Li Y
J Laparoendosc Adv Surg Tech A 2022 Jun;32(6):639-645. Epub 2021 Oct 11 doi: 10.1089/lap.2021.0482. PMID: 34637632
Primary small intestinal neuroendocrine tumors are highly prevalent and often multiple before metastatic disease develops.
Eriksson J, Norlén O, Ögren M, Garmo H, Ihre-Lundgren C, Hellman P
Scand J Surg 2021 Mar;110(1):44-50. Epub 2019 Oct 7 doi: 10.1177/1457496919874484. PMID: 31587594
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Small-cell neuroendocrine carcinoma of the ileum: case report and literature review.
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Composite intestinal adenoma-microcarcinoid.
Lin J, Goldblum JR, Bennett AE, Bronner MP, Liu X
Am J Surg Pathol 2012 Feb;36(2):292-5. doi: 10.1097/PAS.0b013e318236e4d2. PMID: 22082602

Clinical prediction guides

Gastroenteropancreatic neuroendocrine tumours: Clinicopathological evaluation at Shifa International Hospital, Islamabad.
Mamoon N, Naveed H, Abid M, Nasir H, Ahmad IN, Hameed Z, Khan AH
J Pak Med Assoc 2021 Feb;71(2(A)):492-496. doi: 10.47391/JPMA.835. PMID: 33819235
Incidence, survival and stage at diagnosis of small intestinal neuroendocrine tumours in Queensland, Australia, 2001-2015.
Wyld D, Moore J, Tran N, Youl P
Asia Pac J Clin Oncol 2021 Aug;17(4):350-358. Epub 2021 Feb 10 doi: 10.1111/ajco.13503. PMID: 33567164
Small-cell neuroendocrine carcinoma of the ileum: case report and literature review.
Lee JE, Hong SH, Jung HI, Son MW, Ahn TS, Han SW, Cho JH
BMC Surg 2019 Sep 12;19(1):135. doi: 10.1186/s12893-019-0591-8. PMID: 31510991Free PMC Article
Optimal Lymphadenectomy in Small Bowel Neuroendocrine Tumors: Analysis of the NCDB.
Motz BM, Lorimer PD, Boselli D, Hill JS, Salo JC
J Gastrointest Surg 2018 Jan;22(1):117-123. Epub 2017 Aug 17 doi: 10.1007/s11605-017-3524-9. PMID: 28819895
Are G3 ENETS neuroendocrine neoplasms heterogeneous?
Vélayoudom-Céphise FL, Duvillard P, Foucan L, Hadoux J, Chougnet CN, Leboulleux S, Malka D, Guigay J, Goere D, Debaere T, Caramella C, Schlumberger M, Planchard D, Elias D, Ducreux M, Scoazec JY, Baudin E
Endocr Relat Cancer 2013 Oct;20(5):649-57. Epub 2013 Aug 19 doi: 10.1530/ERC-13-0027. PMID: 23845449

Recent systematic reviews

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?
Parra-Medina R, Moreno-Lucero P, Jimenez-Moreno J, Parra-Morales AM, Romero-Rojas A
PLoS One 2019;14(5):e0216647. Epub 2019 May 14 doi: 10.1371/journal.pone.0216647. PMID: 31086397Free PMC Article

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