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Recurrent B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

MedGen UID:
1626864
•Concept ID:
C4525406
•
Neoplastic Process
Synonyms: Recurrent B Acute Lymphoblastic Leukemia with BCR::ABL1-Like Features; Recurrent Ph-Like Acute Lymphoblastic Leukemia

Definition

The reemergence of B acute lymphoblastic leukemia with BCR-ABL1-like features after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent B Acute Lymphoblastic Leukemia with BCR-ABL1-Like Features

Recent clinical studies

Etiology

Mucin 4 protein is expressed in B-acute lymphoblastic leukemia and is restricted to BCR::ABL1-positive and BCR::ABL-like subtypes.
Gestrich CK, De Lancy SJ, Kresak A, Sinno MG, Yalley A, Pateva I, Meyerson H, Shetty S, Oduro KA Jr
Hum Pathol 2023 Jun;136:75-83. Epub 2023 Apr 5 doi: 10.1016/j.humpath.2023.03.018. PMID: 37023866
Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed B-cell acute lymphoblastic leukemia in an Indian cohort.
Virk H, Rana S, Sharma P, Bose PL, Yadav DD, Sachdeva MUS, Varma N, Trehan A, Lad D, Khadwal AR, Malhotra P, Sreedharanunni S
Ann Hematol 2021 Aug;100(8):2031-2041. Epub 2021 Jun 22 doi: 10.1007/s00277-021-04574-0. PMID: 34159401
High incidence of RAS pathway mutations among sentinel genetic lesions of Korean pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Lee JW, Kim Y, Cho B, Kim S, Jang PS, Lee J, Cho H, Lee GD, Chung NG, Kim M
Cancer Med 2020 Jul;9(13):4632-4639. Epub 2020 May 7 doi: 10.1002/cam4.3099. PMID: 32378810Free PMC Article
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article
Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ
Haematologica 2013 Jul;98(7):1081-8. Epub 2013 Mar 18 doi: 10.3324/haematol.2013.085175. PMID: 23508010Free PMC Article

Diagnosis

Hematological characteristics, cytogenetic features, and post-induction measurable residual disease in thymic stromal lymphopoietin receptor (TSLPR) overexpressed B-cell acute lymphoblastic leukemia in an Indian cohort.
Virk H, Rana S, Sharma P, Bose PL, Yadav DD, Sachdeva MUS, Varma N, Trehan A, Lad D, Khadwal AR, Malhotra P, Sreedharanunni S
Ann Hematol 2021 Aug;100(8):2031-2041. Epub 2021 Jun 22 doi: 10.1007/s00277-021-04574-0. PMID: 34159401
High incidence of RAS pathway mutations among sentinel genetic lesions of Korean pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Lee JW, Kim Y, Cho B, Kim S, Jang PS, Lee J, Cho H, Lee GD, Chung NG, Kim M
Cancer Med 2020 Jul;9(13):4632-4639. Epub 2020 May 7 doi: 10.1002/cam4.3099. PMID: 32378810Free PMC Article
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article
Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ
Haematologica 2013 Jul;98(7):1081-8. Epub 2013 Mar 18 doi: 10.3324/haematol.2013.085175. PMID: 23508010Free PMC Article

Therapy

Genes commonly deleted in childhood B-cell precursor acute lymphoblastic leukemia: association with cytogenetics and clinical features.
Schwab CJ, Chilton L, Morrison H, Jones L, Al-Shehhi H, Erhorn A, Russell LJ, Moorman AV, Harrison CJ
Haematologica 2013 Jul;98(7):1081-8. Epub 2013 Mar 18 doi: 10.3324/haematol.2013.085175. PMID: 23508010Free PMC Article

Prognosis

High incidence of RAS pathway mutations among sentinel genetic lesions of Korean pediatric BCR-ABL1-like acute lymphoblastic leukemia.
Lee JW, Kim Y, Cho B, Kim S, Jang PS, Lee J, Cho H, Lee GD, Chung NG, Kim M
Cancer Med 2020 Jul;9(13):4632-4639. Epub 2020 May 7 doi: 10.1002/cam4.3099. PMID: 32378810Free PMC Article
Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article

Clinical prediction guides

Independent prognostic value of BCR-ABL1-like signature and IKZF1 deletion, but not high CRLF2 expression, in children with B-cell precursor ALL.
van der Veer A, Waanders E, Pieters R, Willemse ME, Van Reijmersdal SV, Russell LJ, Harrison CJ, Evans WE, van der Velden VH, Hoogerbrugge PM, Van Leeuwen F, Escherich G, Horstmann MA, Mohammadi Khankahdani L, Rizopoulos D, De Groot-Kruseman HA, Sonneveld E, Kuiper RP, Den Boer ML
Blood 2013 Oct 10;122(15):2622-9. Epub 2013 Aug 23 doi: 10.1182/blood-2012-10-462358. PMID: 23974192Free PMC Article

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