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Benign Infratentorial Neoplasm

MedGen UID:
155591
•Concept ID:
C0751592
•
Neoplastic Process
Synonyms: Benign Infratentorial Neoplasms; Infratentorial Neoplasm, Benign; Infratentorial Neoplasms, Benign; Neoplasm, Benign Infratentorial

Definition

A neoplasm that arises from the infratentorial region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

The evolving role of reirradiation in the management of recurrent brain tumors.
De Pietro R, Zaccaro L, Marampon F, Tini P, De Felice F, Minniti G
J Neurooncol 2023 Sep;164(2):271-286. Epub 2023 Aug 25 doi: 10.1007/s11060-023-04407-2. PMID: 37624529Free PMC Article
EANO-EURACAN clinical practice guideline for diagnosis, treatment, and follow-up of post-pubertal and adult patients with medulloblastoma.
Franceschi E, Hofer S, Brandes AA, Frappaz D, Kortmann RD, Bromberg J, Dangouloff-Ros V, Boddaert N, Hattingen E, Wiestler B, Clifford SC, Figarella-Branger D, Giangaspero F, Haberler C, Pietsch T, Pajtler KW, Pfister SM, Guzman R, Stummer W, Combs SE, Seidel C, Beier D, McCabe MG, Grotzer M, Laigle-Donadey F, Stücklin ASG, Idbaih A, Preusser M, van den Bent M, Weller M, Hau P
Lancet Oncol 2019 Dec;20(12):e715-e728. doi: 10.1016/S1470-2045(19)30669-2. PMID: 31797797
Indian Society of Neuro-Oncology consensus guidelines for the contemporary management of medulloblastoma.
Gupta T, Sarkar C, Rajshekhar V, Chatterjee S, Shirsat N, Muzumdar D, Pungavkar S, Chinnaswamy G, Jalali R
Neurol India 2017 Mar-Apr;65(2):315-332. doi: 10.4103/0028-3886.201841. PMID: 28290395

Recent clinical studies

Etiology

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Pediatric infratentorial ganglioglioma.
Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C
Childs Nerv Syst 2015 Oct;31(10):1707-16. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2860-x. PMID: 26351224
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475

Diagnosis

Posterior Fossa Tumors.
Brandão LA, Young Poussaint T
Neuroimaging Clin N Am 2017 Feb;27(1):1-37. doi: 10.1016/j.nic.2016.08.001. PMID: 27889018
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Pediatric infratentorial ganglioglioma.
Puget S, Alshehri A, Beccaria K, Blauwblomme T, Paternoster G, James S, Dirocco F, Dufour C, Zerah M, Varlet P, Sainte-Rose C
Childs Nerv Syst 2015 Oct;31(10):1707-16. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2860-x. PMID: 26351224
Cerebellar mutism.
Küper M, Timmann D
Brain Lang 2013 Dec;127(3):327-33. Epub 2013 Feb 9 doi: 10.1016/j.bandl.2013.01.001. PMID: 23398780
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475

Therapy

Intraventricular B7-H3 CAR T Cells for Diffuse Intrinsic Pontine Glioma: Preliminary First-in-Human Bioactivity and Safety.
Vitanza NA, Wilson AL, Huang W, Seidel K, Brown C, Gustafson JA, Yokoyama JK, Johnson AJ, Baxter BA, Koning RW, Reid AN, Meechan M, Biery MC, Myers C, Rawlings-Rhea SD, Albert CM, Browd SR, Hauptman JS, Lee A, Ojemann JG, Berens ME, Dun MD, Foster JB, Crotty EE, Leary SES, Cole BL, Perez FA, Wright JN, Orentas RJ, Chour T, Newell EW, Whiteaker JR, Zhao L, Paulovich AG, Pinto N, Gust J, Gardner RA, Jensen MC, Park JR
Cancer Discov 2023 Jan 9;13(1):114-131. doi: 10.1158/2159-8290.CD-22-0750. PMID: 36259971Free PMC Article
Cancer-selective metabolic vulnerabilities in MYC-amplified medulloblastoma.
Gwynne WD, Suk Y, Custers S, Mikolajewicz N, Chan JK, Zador Z, Chafe SC, Zhai K, Escudero L, Zhang C, Zaslaver O, Chokshi C, Shaikh MV, Bakhshinyan D, Burns I, Chaudhry I, Nachmani O, Mobilio D, Maich WT, Mero P, Brown KR, Quaile AT, Venugopal C, Moffat J, Montenegro-Burke JR, Singh SK
Cancer Cell 2022 Dec 12;40(12):1488-1502.e7. Epub 2022 Nov 10 doi: 10.1016/j.ccell.2022.10.009. PMID: 36368321
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y, Embry L, Hadley J, Kumar R, Michalski J, Hwang E, Gajjar A, Pollack IF, Fouladi M, Northcott PA, Olson JM
JAMA Oncol 2021 Sep 1;7(9):1313-1321. doi: 10.1001/jamaoncol.2021.2224. PMID: 34292305Free PMC Article
Diffuse Intrinsic Pontine Glioma (DIPG): Breakthrough and Clinical Perspective.
Perrone MG, Ruggiero A, Centonze A, Carrieri A, Ferorelli S, Scilimati A
Curr Med Chem 2021;28(17):3287-3317. doi: 10.2174/0929867327666200806110206. PMID: 32767913
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066

Prognosis

TULIPs decorate the three-dimensional genome of PFA ependymoma.
Johnston MJ, Lee JJY, Hu B, Nikolic A, Hasheminasabgorji E, Baguette A, Paik S, Chen H, Kumar S, Chen CCL, Jessa S, Balin P, Fong V, Zwaig M, Michealraj KA, Chen X, Zhang Y, Varadharajan S, Billon P, Juretic N, Daniels C, Rao AN, Giannini C, Thompson EM, Garami M, Hauser P, Pocza T, Ra YS, Cho BK, Kim SK, Wang KC, Lee JY, Grajkowska W, Perek-Polnik M, Agnihotri S, Mack S, Ellezam B, Weil A, Rich J, Bourque G, Chan JA, Yong VW, Lupien M, Ragoussis J, Kleinman C, Majewski J, Blanchette M, Jabado N, Taylor MD, Gallo M
Cell 2024 Sep 5;187(18):4926-4945.e22. Epub 2024 Jul 9 doi: 10.1016/j.cell.2024.06.023. PMID: 38986619
Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995
Ependymoma.
Reni M, Gatta G, Mazza E, Vecht C
Crit Rev Oncol Hematol 2007 Jul;63(1):81-9. Epub 2007 May 4 doi: 10.1016/j.critrevonc.2007.03.004. PMID: 17482475

Clinical prediction guides

Updates in the classification of ependymal neoplasms: The 2021 WHO Classification and beyond.
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
Gajjar A, Robinson GW, Smith KS, Lin T, Merchant TE, Chintagumpala M, Mahajan A, Su J, Bouffet E, Bartels U, Schechter T, Hassall T, Robertson T, Nicholls W, Gururangan S, Schroeder K, Sullivan M, Wheeler G, Hansford JR, Kellie SJ, McCowage G, Cohn R, Fisher MJ, Krasin MJ, Stewart CF, Broniscer A, Buchhalter I, Tatevossian RG, Orr BA, Neale G, Klimo P Jr, Boop F, Srinivasan A, Pfister SM, Gilbertson RJ, Onar-Thomas A, Ellison DW, Northcott PA
J Clin Oncol 2021 Mar 1;39(7):822-835. Epub 2021 Jan 6 doi: 10.1200/JCO.20.01372. PMID: 33405951Free PMC Article
Medulloblastoma: Clinical presentation.
Vinchon M, Leblond P
Neurochirurgie 2021 Feb;67(1):23-27. Epub 2019 Sep 5 doi: 10.1016/j.neuchi.2019.04.006. PMID: 31494131
Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM
Lancet Oncol 2018 Jun;19(6):785-798. Epub 2018 May 9 doi: 10.1016/S1470-2045(18)30242-0. PMID: 29753700Free PMC Article
Childhood medulloblastoma.
Massimino M, Giangaspero F, Garrè ML, Gandola L, Poggi G, Biassoni V, Gatta G, Rutkowski S
Crit Rev Oncol Hematol 2011 Jul;79(1):65-83. Epub 2010 Dec 3 doi: 10.1016/j.critrevonc.2010.07.010. PMID: 21129995

Recent systematic reviews

Radiation-induced cavernoma in pediatric CNS tumors: a systematic review and treatment paradigm.
Vacek A, Kaliaperumal C
Childs Nerv Syst 2024 Nov;40(11):3527-3536. Epub 2024 Jul 19 doi: 10.1007/s00381-024-06543-0. PMID: 39028348Free PMC Article
Pachymeningeal disease: a systematic review and metanalysis.
Gutiérrez-Valencia E, Sánchez I, Valles A, Díaz O, F González T, Balderrama R, Fuentes J, Ruiz V, Rodríguez J, Saavedra C, Velázquez-Pulido L, Cadavid E, E Ayala-Hernández L, Villalvazo A, H Bayardo L, Jamora K, Kalyvas A, Yang K, Millar BA, B Shultz D
J Neurooncol 2023 Oct;165(1):29-39. Epub 2023 Oct 10 doi: 10.1007/s11060-023-04476-3. PMID: 37815737
Survival and neurological outcomes after stereotactic biopsy of diffuse intrinsic pontine glioma: a systematic review.
Dalmage M, LoPresti MA, Sarkar P, Ranganathan S, Abdelmageed S, Pagadala M, Shlobin NA, Lam S, DeCuypere M
J Neurosurg Pediatr 2023 Dec 1;32(6):665-672. Epub 2023 Sep 8 doi: 10.3171/2023.7.PEDS22462. PMID: 37724839
Supratentorial Hemangioblastoma in Adults: A Systematic Review and Comparison of Infratentorial and Spinal Cord Locations.
Jankovic D, Vuong K, Splavski B, Rotim K, Arnautovic KI
World Neurosurg 2023 May;173:48-62. Epub 2023 Feb 22 doi: 10.1016/j.wneu.2023.02.071. PMID: 36822402
Teflon granulomas mimicking cerebellopontine angle tumors following microvascular decompression.
Deep NL, Graffeo CS, Copeland WR 3rd, Link MJ, Atkinson JL, Neff BA, Raghunathan A, Carlson ML
Laryngoscope 2017 Mar;127(3):715-719. Epub 2016 Jun 19 doi: 10.1002/lary.26126. PMID: 27320780

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