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Bone benign neoplasm

MedGen UID:
146337
•Concept ID:
C0684516
•
Neoplastic Process
Synonyms: Benign Bone Neoplasm; benign bone neoplasm; Benign bone tumor; Benign Bone Tumor; benign bone tumor; benign bone tumour; Benign neoplasm of bone; Benign Neoplasm of Bone; benign neoplasm of bone; Benign Neoplasm of the Bone; benign neoplasm of the bone; Benign Osseous Neoplasm; benign osseous neoplasm; Benign Osseous Tumor; benign osseous tumor; benign osseous tumour; Benign Tumor of Bone; benign tumor of bone; Benign Tumor of the Bone; benign tumor of the bone; benign tumour of bone; benign tumour of the bone; bone benign neoplasm; bone tissue benign neoplasm
SNOMED CT: Benign neoplasm of bone (92027006); Benign bone tumor (92027006)
 
Monarch Initiative: MONDO:0000631

Definition

A mesenchymal neoplasm that arises from bone or articular cartilage and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations.
Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, Frost MD, Fuchs Z, Gosnell ES, Gupta N, Jansen AC, Jóźwiak S, Kingswood JC, Knilans TK, McCormack FX, Pounders A, Roberds SL, Rodriguez-Buritica DF, Roth J, Sampson JR, Sparagana S, Thiele EA, Weiner HL, Wheless JW, Towbin AJ, Krueger DA; International Tuberous Sclerosis Complex Consensus Group
Pediatr Neurol 2021 Oct;123:50-66. Epub 2021 Jul 24 doi: 10.1016/j.pediatrneurol.2021.07.011. PMID: 34399110
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF
Lancet Oncol 2014 Nov;15(12):e538-48. Epub 2014 Oct 26 doi: 10.1016/S1470-2045(14)70442-5. PMID: 25439696
KDIGO clinical practice guideline for the care of kidney transplant recipients.
Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group
Am J Transplant 2009 Nov;9 Suppl 3:S1-155. doi: 10.1111/j.1600-6143.2009.02834.x. PMID: 19845597

Recent clinical studies

Etiology

Animal models for bone tissue engineering and modelling disease.
McGovern JA, Griffin M, Hutmacher DW
Dis Model Mech 2018 Apr 23;11(4) doi: 10.1242/dmm.033084. PMID: 29685995Free PMC Article
Cancer Treatment and Bone Health.
Handforth C, D'Oronzo S, Coleman R, Brown J
Calcif Tissue Int 2018 Feb;102(2):251-264. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0369-x. PMID: 29353450Free PMC Article
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652
Pathology of osteosarcoma.
Dahlin DC
Clin Orthop Relat Res 1975 Sep;(111):23-32. doi: 10.1097/00003086-197509000-00004. PMID: 168999

Diagnosis

Osteochondrolipoma of the Hand.
Van Demark RE Jr, Fiegen T, Hayes M, Hayes M, Sunassee A, Helsper E
J Hand Surg Am 2022 Sep;47(9):904.e1-904.e4. Epub 2021 Jul 24 doi: 10.1016/j.jhsa.2021.05.024. PMID: 34312026
Understanding Unicameral and Aneurysmal Bone Cysts.
Rosenblatt J, Koder A
Pediatr Rev 2019 Feb;40(2):51-59. doi: 10.1542/pir.2015-0128. PMID: 30709971
Chondroblastoma: An Update.
Chen W, DiFrancesco LM
Arch Pathol Lab Med 2017 Jun;141(6):867-871. doi: 10.5858/arpa.2016-0281-RS. PMID: 28557595
ADR--Anatomy-Driven Reformation.
Kretschmer J, Soza G, Tietjen C, Suehling M, Preim B, Stamminger M
IEEE Trans Vis Comput Graph 2014 Dec;20(12):2496-505. doi: 10.1109/TVCG.2014.2346405. PMID: 26356963
Characterization of osteosarcoma cell lines MG-63, Saos-2 and U-2 OS in comparison to human osteoblasts.
Pautke C, Schieker M, Tischer T, Kolk A, Neth P, Mutschler W, Milz S
Anticancer Res 2004 Nov-Dec;24(6):3743-8. PMID: 15736406

Therapy

Bone metastasis: mechanisms, therapies, and biomarkers.
Clézardin P, Coleman R, Puppo M, Ottewell P, Bonnelye E, Paycha F, Confavreux CB, Holen I
Physiol Rev 2021 Jul 1;101(3):797-855. Epub 2020 Dec 24 doi: 10.1152/physrev.00012.2019. PMID: 33356915
Cancer Treatment and Bone Health.
Handforth C, D'Oronzo S, Coleman R, Brown J
Calcif Tissue Int 2018 Feb;102(2):251-264. Epub 2018 Jan 20 doi: 10.1007/s00223-017-0369-x. PMID: 29353450Free PMC Article
Skeletal Scintigraphy.
Montilla-Soler JL, Makanji R
Cancer Control 2017 Apr;24(2):137-146. doi: 10.1177/107327481702400206. PMID: 28441368
Molecular and pharmacological aspects of existing and experimental bone anabolic therapies.
Chattopadhyay N
Curr Mol Pharmacol 2012 Jun;5(2):125-6. doi: 10.2174/1874467211205020125. PMID: 21787294
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652

Prognosis

Medication-Related Osteonecrosis of the Jaws.
Migliorati CA, Brennan MT, Peterson DE
J Natl Cancer Inst Monogr 2019 Aug 1;2019(53) doi: 10.1093/jncimonographs/lgz009. PMID: 31425596
Imaging of Multiple Myeloma.
Kosmala A, Bley T, Petritsch B
Rofo 2019 Sep;191(9):805-816. Epub 2019 Jun 11 doi: 10.1055/a-0864-2084. PMID: 31185511
Hallmarks of Bone Metastasis.
Johnson RW, Suva LJ
Calcif Tissue Int 2018 Feb;102(2):141-151. Epub 2017 Nov 14 doi: 10.1007/s00223-017-0362-4. PMID: 29138883Free PMC Article
Bisphosphonates in oncology.
Coleman RE, McCloskey EV
Bone 2011 Jul;49(1):71-6. Epub 2011 Feb 21 doi: 10.1016/j.bone.2011.02.003. PMID: 21320652
Pathology of osteosarcoma.
Dahlin DC
Clin Orthop Relat Res 1975 Sep;(111):23-32. doi: 10.1097/00003086-197509000-00004. PMID: 168999

Clinical prediction guides

Frequency of superscan on bone scintigraphy: A systematic review.
Kovacsne A, Kozon I, Bentestuen M, Zacho HD
Clin Physiol Funct Imaging 2023 Sep;43(5):297-304. Epub 2023 Apr 25 doi: 10.1111/cpf.12821. PMID: 37070619
Novel Techniques to Study the Bone-Tumor Microenvironment.
Shupp AB, Kolb AD, Bussard KM
Adv Exp Med Biol 2020;1225:1-18. doi: 10.1007/978-3-030-35727-6_1. PMID: 32030644
Adrenocortical incidentalomas and bone: from molecular insights to clinical perspectives.
Altieri B, Muscogiuri G, Paschou SA, Vryonidou A, Della Casa S, Pontecorvi A, Fassnacht M, Ronchi CL, Newell-Price J
Endocrine 2018 Dec;62(3):506-516. Epub 2018 Aug 2 doi: 10.1007/s12020-018-1696-z. PMID: 30073456
Endothelin Signaling in Bone.
Kristianto J, Johnson MG, Afzal R, Blank RD
Endocrinol Metab Clin North Am 2017 Mar;46(1):51-62. Epub 2016 Nov 26 doi: 10.1016/j.ecl.2016.09.014. PMID: 28131136Free PMC Article
MicroRNAs in osteosarcomagenesis.
Kafchinski LA, Jones KB
Adv Exp Med Biol 2014;804:119-27. doi: 10.1007/978-3-319-04843-7_6. PMID: 24924171

Recent systematic reviews

Sacral Tarlov perineurial cysts: a systematic review of treatment options.
Paredes Mogica JA, Feigenbaum F, Pilitsis JG, Schrot RJ, Oaklander AL, De EJB
J Neurosurg Spine 2024 Mar 1;40(3):375-388. Epub 2023 Dec 15 doi: 10.3171/2023.9.SPINE23559. PMID: 38100766
Papilliferous Keratoameloblastoma: Systematic review.
Sachdev SS, Chettiankandy TJ, Adhane YB, Sardar MA, Trimukhe A, Jain R
Sultan Qaboos Univ Med J 2023 Aug;23(3):288-296. Epub 2023 Aug 28 doi: 10.18295/squmj.5.2023.021. PMID: 37655071Free PMC Article
Skull base hemangiopericytomas.
Tobias S, Jahshan S, Grober Y, Soustiel JF
Acta Neurol Belg 2022 Dec;122(6):1537-1545. Epub 2021 Sep 30 doi: 10.1007/s13760-021-01812-0. PMID: 34595730
Vertebral Pneumatocyst-A Systematic Review.
Garg K, Dash A, Aggarwal A, Duetzmann S
World Neurosurg 2021 Jul;151:77-86. Epub 2021 Apr 29 doi: 10.1016/j.wneu.2021.04.092. PMID: 33933696
Oral radiation-induced sarcomas: Systematic review.
de Souza LL, Pontes HAR, Santos-Silva AR, Fernandes LA, Batista LAL, Lopes MA, Khan W, Pontes FSC
Head Neck 2020 Sep;42(9):2660-2668. Epub 2020 Apr 28 doi: 10.1002/hed.26176. PMID: 32343457

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