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Schizophrenia Spectrum and Other Psychotic Disorders

MedGen UID:
141907
•Concept ID:
C0525046
•
Mental or Behavioral Dysfunction
Synonym: Schizophrenia and Disorders with Psychotic Features

Definition

Marked disorders of thought (delusions, hallucinations, or other thought disorder accompanied by disordered affect or behavior), and deterioration from a previous level of functioning. Individuals have one o more of the following symptoms: delusions, hallucinations, and disorganized speech. (from DSM-5) [from MeSH]

Professional guidelines

PubMed

Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.
Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394
Care Management for Serious Mental Illness: A Systematic Review and Meta-Analysis.
Lim CT, Caan MP, Kim CH, Chow CM, Leff HS, Tepper MC
Psychiatr Serv 2022 Feb 1;73(2):180-187. Epub 2021 Jul 13 doi: 10.1176/appi.ps.202000473. PMID: 34253036
Depression and Schizophrenia: Sleep, Medical Risk Factors, Biomarkers, and Treatment.
Kalin NH
Am J Psychiatry 2021 Oct 1;178(10):881-884. doi: 10.1176/appi.ajp.2021.21080824. PMID: 34592847

Recent clinical studies

Etiology

Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors.
Rødevand L, Rahman Z, Hindley GFL, Smeland OB, Frei O, Tekin TF, Kutrolli G, Bahrami S, Hoseth EZ, Shadrin A, Lin A, Djurovic S, Dale AM, Steen NE, Andreassen OA
Am J Psychiatry 2023 Nov 1;180(11):815-826. Epub 2023 Sep 27 doi: 10.1176/appi.ajp.20220660. PMID: 37752828
Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder.
Rognli EB, Heiberg IH, Jacobsen BK, Høye A, Bramness JG
Am J Psychiatry 2023 Jun 1;180(6):437-444. Epub 2023 May 3 doi: 10.1176/appi.ajp.22010076. PMID: 37132221
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

Diagnosis

Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder.
Rognli EB, Heiberg IH, Jacobsen BK, Høye A, Bramness JG
Am J Psychiatry 2023 Jun 1;180(6):437-444. Epub 2023 May 3 doi: 10.1176/appi.ajp.22010076. PMID: 37132221
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535

Therapy

Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211
Safety of Antipsychotic Polypharmacy Versus Monotherapy in a Nationwide Cohort of 61,889 Patients With Schizophrenia.
Taipale H, Tanskanen A, Tiihonen J
Am J Psychiatry 2023 May 1;180(5):377-385. Epub 2023 Mar 22 doi: 10.1176/appi.ajp.20220446. PMID: 36945825
Dementia Is More Than Memory Loss: Neuropsychiatric Symptoms of Dementia and Their Nonpharmacological and Pharmacological Management.
Tampi RR, Jeste DV
Am J Psychiatry 2022 Aug;179(8):528-543. doi: 10.1176/appi.ajp.20220508. PMID: 35921394
Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.
Paul SM, Yohn SE, Popiolek M, Miller AC, Felder CC
Am J Psychiatry 2022 Sep;179(9):611-627. Epub 2022 Jun 27 doi: 10.1176/appi.ajp.21101083. PMID: 35758639
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article

Prognosis

Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Schizophrenia spectrum and other psychotic disorders.
Lewine R, Hart M
Handb Clin Neurol 2020;175:315-333. doi: 10.1016/B978-0-444-64123-6.00022-9. PMID: 33008535
Psychotic Experiences, Cognitive Decline, and Genetic Vulnerabilities in Relation to Developing Psychotic Disorders.
Kalin NH
Am J Psychiatry 2020 Apr 1;177(4):279-281. doi: 10.1176/appi.ajp.2020.20020162. PMID: 32233681
Self-disorders in Early Stages of the Schizophrenia Spectrum.
Valle R, Perales A
Rev Colomb Psiquiatr (Engl Ed) 2019 Oct-Dec;48(4):244-251. Epub 2018 Mar 20 doi: 10.1016/j.rcp.2018.02.003. PMID: 31779875

Clinical prediction guides

Risk of Incident Psychosis and Mania With Prescription Amphetamines.
Moran LV, Skinner JP, Shinn AK, Nielsen K, Rao V, Taylor ST, Cohen TR, Erkol C, Merchant J, Mujica CA, Perlis RH, Ongur D
Am J Psychiatry 2024 Oct 1;181(10):901-909. Epub 2024 Sep 12 doi: 10.1176/appi.ajp.20230329. PMID: 39262211
Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.
Joshi YB, Thomas ML, Braff DL, Green MF, Gur RC, Gur RE, Nuechterlein KH, Stone WS, Greenwood TA, Lazzeroni LC, MacDonald LR, Molina JL, Nungaray JA, Radant AD, Silverman JM, Sprock J, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Swerdlow NR, Light GA
Am J Psychiatry 2021 Sep 1;178(9):838-847. Epub 2021 May 14 doi: 10.1176/appi.ajp.2020.20081212. PMID: 33985348Free PMC Article
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Ferrarelli F
Am J Psychiatry 2021 Oct 1;178(10):903-913. Epub 2021 Mar 17 doi: 10.1176/appi.ajp.2020.20070968. PMID: 33726524Free PMC Article
Neuroimaging Biomarkers in Schizophrenia.
Kraguljac NV, McDonald WM, Widge AS, Rodriguez CI, Tohen M, Nemeroff CB
Am J Psychiatry 2021 Jun;178(6):509-521. Epub 2021 Jan 5 doi: 10.1176/appi.ajp.2020.20030340. PMID: 33397140Free PMC Article
Self-disorders in Early Stages of the Schizophrenia Spectrum.
Valle R, Perales A
Rev Colomb Psiquiatr (Engl Ed) 2019 Oct-Dec;48(4):244-251. Epub 2018 Mar 20 doi: 10.1016/j.rcp.2018.02.003. PMID: 31779875

Recent systematic reviews

Prevalence of schizophrenia spectrum and other psychotic disorders in problem gambling: A systematic review and meta-analysis.
Corbeil O, Béchard L, Anderson É, Huot-Lavoie M, Desmeules C, Bachand L, Brodeur S, Carmichael PH, Jacques C, Solmi M, Dorval M, Giroux I, Roy MA, Demers MF
Eur Psychiatry 2024 Sep 25;67(1):e56. doi: 10.1192/j.eurpsy.2024.1777. PMID: 39320504
Cognition and gut microbiota in schizophrenia spectrum and mood disorders: A systematic review.
Frileux S, Boltri M, Doré J, Leboyer M, Roux P
Neurosci Biobehav Rev 2024 Jul;162:105722. Epub 2024 May 15 doi: 10.1016/j.neubiorev.2024.105722. PMID: 38754717
The relationship between sleep and suicidality in schizophrenia spectrum and other psychotic disorders: A systematic review.
Rogers E, Gresswell M, Durrant S
Schizophr Res 2023 Nov;261:291-303. Epub 2023 Oct 23 doi: 10.1016/j.schres.2023.10.010. PMID: 37879227
The role of alcohol intake in the pharmacogenetics of treatment with clozapine.
Monroy-Jaramillo N, Martínez-Magaña JJ, Pérez-Aldana BE, Ortega-Vázquez A, Montalvo-Ortiz J, López-López M
Pharmacogenomics 2022 Apr;23(6):371-392. Epub 2022 Mar 21 doi: 10.2217/pgs-2022-0006. PMID: 35311547
Adiposity in schizophrenia: A systematic review and meta-analysis.
Smith E, Singh R, Lee J, Colucci L, Graff-Guerrero A, Remington G, Hahn M, Agarwal SM
Acta Psychiatr Scand 2021 Dec;144(6):524-536. Epub 2021 Sep 16 doi: 10.1111/acps.13365. PMID: 34458979

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