U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Substance-induced psychosis

MedGen UID:
18746
•Concept ID:
C0033941
•
Mental or Behavioral Dysfunction
Synonyms: Psychoses, Substance Induced; Psychoses, Substance-Induced; Psychoses, Toxic; Substance Induced Psychoses; Substance-Induced Psychoses; Toxic Psychoses
 
Monarch Initiative: MONDO:0004630

Definition

Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubstance-induced psychosis

Professional guidelines

PubMed

What is the Link Between Substance-Induced Psychosis and Primary Psychotic Disorders?
Vassos E
Am J Psychiatry 2023 Jun 1;180(6):404-406. doi: 10.1176/appi.ajp.20230298. PMID: 37259511
Personalized risk assessment of drug-related harm is associated with health outcomes.
Jones AA, Vila-Rodriguez F, Panenka WJ, Leonova O, Strehlau V, Lang DJ, Thornton AE, Wong H, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, Montaner JS, Macewan GW, Nutt DJ, Honer WG
PLoS One 2013;8(11):e79754. Epub 2013 Nov 6 doi: 10.1371/journal.pone.0079754. PMID: 24223192Free PMC Article
Developing and testing adaptive treatment strategies using substance-induced psychosis as an example.
Dawson R, Green AI, Drake RE, McGlashan TH, Schanzer B, Lavori PW
Psychopharmacol Bull 2008;41(3):51-67. PMID: 18779776Free PMC Article

Recent clinical studies

Etiology

Managing drug-induced psychosis.
Baldaçara L, Ramos A, Castaldelli-Maia JM
Int Rev Psychiatry 2023 Aug-Sep;35(5-6):496-502. Epub 2024 Feb 1 doi: 10.1080/09540261.2023.2261544. PMID: 38299647
Transition to Schizophrenia Spectrum Disorder Following Emergency Department Visits Due to Substance Use With and Without Psychosis.
Myran DT, Harrison LD, Pugliese M, Solmi M, Anderson KK, Fiedorowicz JG, Perlman CM, Webber C, Finkelstein Y, Tanuseputro P
JAMA Psychiatry 2023 Nov 1;80(11):1169-1174. doi: 10.1001/jamapsychiatry.2023.3582. PMID: 37755727Free PMC Article
Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder.
Rognli EB, Heiberg IH, Jacobsen BK, Høye A, Bramness JG
Am J Psychiatry 2023 Jun 1;180(6):437-444. Epub 2023 May 3 doi: 10.1176/appi.ajp.22010076. PMID: 37132221
Diagnostic stability in substance-induced psychosis.
Inchausti L, Gorostiza I, Gonzalez Torres MA, Oraa R
Rev Psiquiatr Salud Ment (Engl Ed) 2022 Oct-Dec;15(4):272-280. Epub 2022 Nov 16 doi: 10.1016/j.rpsmen.2019.10.006. PMID: 36400700
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.
Starzer MSK, Nordentoft M, Hjorthøj C
Am J Psychiatry 2018 Apr 1;175(4):343-350. Epub 2017 Nov 28 doi: 10.1176/appi.ajp.2017.17020223. PMID: 29179576

Diagnosis

Managing drug-induced psychosis.
Baldaçara L, Ramos A, Castaldelli-Maia JM
Int Rev Psychiatry 2023 Aug-Sep;35(5-6):496-502. Epub 2024 Feb 1 doi: 10.1080/09540261.2023.2261544. PMID: 38299647
Transition From Substance-Induced Psychosis to Schizophrenia Spectrum Disorder or Bipolar Disorder.
Rognli EB, Heiberg IH, Jacobsen BK, Høye A, Bramness JG
Am J Psychiatry 2023 Jun 1;180(6):437-444. Epub 2023 May 3 doi: 10.1176/appi.ajp.22010076. PMID: 37132221
Diagnostic stability in substance-induced psychosis.
Inchausti L, Gorostiza I, Gonzalez Torres MA, Oraa R
Rev Psiquiatr Salud Ment (Engl Ed) 2022 Oct-Dec;15(4):272-280. Epub 2022 Nov 16 doi: 10.1016/j.rpsmen.2019.10.006. PMID: 36400700
Substance-induced Psychosis in Youth.
Beckmann D, Lowman KL, Nargiso J, McKowen J, Watt L, Yule AM
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):131-143. Epub 2019 Sep 23 doi: 10.1016/j.chc.2019.08.006. PMID: 31708042Free PMC Article
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.
Starzer MSK, Nordentoft M, Hjorthøj C
Am J Psychiatry 2018 Apr 1;175(4):343-350. Epub 2017 Nov 28 doi: 10.1176/appi.ajp.2017.17020223. PMID: 29179576

Therapy

Managing drug-induced psychosis.
Baldaçara L, Ramos A, Castaldelli-Maia JM
Int Rev Psychiatry 2023 Aug-Sep;35(5-6):496-502. Epub 2024 Feb 1 doi: 10.1080/09540261.2023.2261544. PMID: 38299647
Transition to Schizophrenia Spectrum Disorder Following Emergency Department Visits Due to Substance Use With and Without Psychosis.
Myran DT, Harrison LD, Pugliese M, Solmi M, Anderson KK, Fiedorowicz JG, Perlman CM, Webber C, Finkelstein Y, Tanuseputro P
JAMA Psychiatry 2023 Nov 1;80(11):1169-1174. doi: 10.1001/jamapsychiatry.2023.3582. PMID: 37755727Free PMC Article
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.
Starzer MSK, Nordentoft M, Hjorthøj C
Am J Psychiatry 2018 Apr 1;175(4):343-350. Epub 2017 Nov 28 doi: 10.1176/appi.ajp.2017.17020223. PMID: 29179576
Psychosis induced by amphetamines.
Bramness JG, Rognli EB
Curr Opin Psychiatry 2016 Jul;29(4):236-41. doi: 10.1097/YCO.0000000000000254. PMID: 27175554
N,N-Dimethyltryptamine-Induced Psychosis.
Paterson NE, Darby WC, Sandhu PS
Clin Neuropharmacol 2015 Jul-Aug;38(4):141-3. doi: 10.1097/WNF.0000000000000078. PMID: 26166234

Prognosis

Clinical Recovery and Long-Term Association of Specialized Early Intervention Services vs Treatment as Usual Among Individuals With First-Episode Schizophrenia Spectrum Disorder: 20-Year Follow-up of the OPUS Trial.
Hansen HG, Starzer M, Nilsson SF, Hjorthøj C, Albert N, Nordentoft M
JAMA Psychiatry 2023 Apr 1;80(4):371-379. doi: 10.1001/jamapsychiatry.2022.5164. PMID: 36811902Free PMC Article
Diagnostic stability in substance-induced psychosis.
Inchausti L, Gorostiza I, Gonzalez Torres MA, Oraa R
Rev Psiquiatr Salud Ment (Engl Ed) 2022 Oct-Dec;15(4):272-280. Epub 2022 Nov 16 doi: 10.1016/j.rpsmen.2019.10.006. PMID: 36400700
Substance-induced Psychosis in Youth.
Beckmann D, Lowman KL, Nargiso J, McKowen J, Watt L, Yule AM
Child Adolesc Psychiatr Clin N Am 2020 Jan;29(1):131-143. Epub 2019 Sep 23 doi: 10.1016/j.chc.2019.08.006. PMID: 31708042Free PMC Article
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.
Starzer MSK, Nordentoft M, Hjorthøj C
Am J Psychiatry 2018 Apr 1;175(4):343-350. Epub 2017 Nov 28 doi: 10.1176/appi.ajp.2017.17020223. PMID: 29179576
N,N-Dimethyltryptamine-Induced Psychosis.
Paterson NE, Darby WC, Sandhu PS
Clin Neuropharmacol 2015 Jul-Aug;38(4):141-3. doi: 10.1097/WNF.0000000000000078. PMID: 26166234

Clinical prediction guides

The transition to Schizophrenia spectrum disorder from a first psychotic episode that did or did not appear to be induced by substance use.
Inchausti L, Gorostiza I, Gonzalez Torres MA, Oraa R
Psychiatry Res 2023 Oct;328:115475. Epub 2023 Sep 10 doi: 10.1016/j.psychres.2023.115475. PMID: 37713923
Clinical Recovery and Long-Term Association of Specialized Early Intervention Services vs Treatment as Usual Among Individuals With First-Episode Schizophrenia Spectrum Disorder: 20-Year Follow-up of the OPUS Trial.
Hansen HG, Starzer M, Nilsson SF, Hjorthøj C, Albert N, Nordentoft M
JAMA Psychiatry 2023 Apr 1;80(4):371-379. doi: 10.1001/jamapsychiatry.2022.5164. PMID: 36811902Free PMC Article
Mortality in substance-induced psychosis: a register-based national cohort study.
Hjorthøj C, Madsen T, Starzer M, Erlangsen A, Nordentoft M
Addiction 2021 Dec;116(12):3515-3524. Epub 2021 Jun 24 doi: 10.1111/add.15598. PMID: 34105214
Infections as a Risk Factor for and Prognostic Factor After Substance-Induced Psychoses.
Hjorthøj C, Starzer MSK, Benros ME, Nordentoft M
Am J Psychiatry 2020 Apr 1;177(4):335-341. Epub 2020 Feb 12 doi: 10.1176/appi.ajp.2019.19101047. PMID: 32046532
Rates and Predictors of Conversion to Schizophrenia or Bipolar Disorder Following Substance-Induced Psychosis.
Starzer MSK, Nordentoft M, Hjorthøj C
Am J Psychiatry 2018 Apr 1;175(4):343-350. Epub 2017 Nov 28 doi: 10.1176/appi.ajp.2017.17020223. PMID: 29179576

Recent systematic reviews

A systematic review and meta-analysis of synthetic cathinone use and psychosis.
Daswani RR, Choles CM, Kim DD, Barr AM
Psychopharmacology (Berl) 2024 May;241(5):875-896. Epub 2024 Mar 6 doi: 10.1007/s00213-024-06569-x. PMID: 38446172
On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.
Benrimoh D, Dlugunovych V, Wright AC, Phalen P, Funaro MC, Ferrara M, Powers AR 3rd, Woods SW, Guloksuz S, Yung AR, Srihari V, Shah J
Mol Psychiatry 2024 May;29(5):1361-1381. Epub 2024 Feb 2 doi: 10.1038/s41380-024-02415-w. PMID: 38302562
Substance-induced psychosis and cognitive functioning: A systematic review.
Gicas KM, Parmar PK, Fabiano GF, Mashhadi F
Psychiatry Res 2022 Feb;308:114361. Epub 2021 Dec 28 doi: 10.1016/j.psychres.2021.114361. PMID: 34979380
Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis.
Murrie B, Lappin J, Large M, Sara G
Schizophr Bull 2020 Apr 10;46(3):505-516. doi: 10.1093/schbul/sbz102. PMID: 31618428Free PMC Article
Incidence of schizophrenia and other psychoses in England, 1950-2009: a systematic review and meta-analyses.
Kirkbride JB, Errazuriz A, Croudace TJ, Morgan C, Jackson D, Boydell J, Murray RM, Jones PB
PLoS One 2012;7(3):e31660. Epub 2012 Mar 22 doi: 10.1371/journal.pone.0031660. PMID: 22457710Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...