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Metastatic Lip Squamous Cell Carcinoma

MedGen UID:
1659624
•Concept ID:
C4744560
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the lip and has metastasized to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Lip Squamous Cell Carcinoma

Professional guidelines

PubMed

Lower lip basal cell and squamous cell carcinomas: a reappraisal of the similarities and differences in clinical presentation and management.
Hwang JR, Khachemoune A
Arch Dermatol Res 2023 Mar;315(2):117-125. Epub 2022 Mar 21 doi: 10.1007/s00403-022-02345-z. PMID: 35312855
Lip cancer: Reconsidering the at-risk patients with pathological assessment.
Ant A, Kilic C, Baltu Y, Duran AB, Tunccan T, Ozlugedik S, Bozdogan N
Oral Dis 2019 Apr;25(3):742-749. Epub 2019 Jan 23 doi: 10.1111/odi.13017. PMID: 30548899
Cheilitis glandularis: clinico-histopathological diagnostic criteria.
Reiter S, Vered M, Yarom N, Goldsmith C, Gorsky M
Oral Dis 2011 Apr;17(3):335-9. Epub 2010 Oct 28 doi: 10.1111/j.1601-0825.2010.01762.x. PMID: 21029266

Recent clinical studies

Etiology

Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain.
Rodríguez-Blanco I, Flórez Á, Paredes-Suárez C, Rodríguez-Lojo R, González-Vilas D, Ramírez-Santos A, Paradela S, Suárez Conde I, Pereiro-Ferreirós M
Acta Derm Venereol 2018 Nov 5;98(10):970-974. doi: 10.2340/00015555-3014. PMID: 30085328
Reconstruction of Tongue Defects With the Contralateral Nasolabial Island Flap.
Nueangkhota P, Liang YJ, Zheng GS, Su YX, Yang WF, Liao GQ
J Oral Maxillofac Surg 2016 Apr;74(4):851-9. Epub 2015 Oct 23 doi: 10.1016/j.joms.2015.10.013. PMID: 26549474
Secondary tarsoconjunctival graft: a modification to the Cutler-Beard procedure.
Yoon MK, McCulley TJ
Ophthalmic Plast Reconstr Surg 2013 May-Jun;29(3):227-30. doi: 10.1097/IOP.0b013e3182831c84. PMID: 23446299
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725

Diagnosis

Exogenous Lipoid Pneumonia in Laryngectomy Patients: Radiological Findings.
García Latorre R, Rodríguez Díaz R, Barrios Barreto D, Ayala Carbonero A, García Gómez-Muriel MI, Gorospe Sarasúa L
Arch Bronconeumol 2015 Jul;51(7):e36-9. Epub 2014 Oct 23 doi: 10.1016/j.arbres.2014.09.002. PMID: 25446870
Solar cheilosis: an ominous precursor part II. Therapeutic perspectives.
Jadotte YT, Schwartz RA
J Am Acad Dermatol 2012 Feb;66(2):187-98; quiz 199-200. doi: 10.1016/j.jaad.2011.09.039. PMID: 22243722
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Markers of metastasis in lip cancer.
Fernández-Angel I, Rodríguez-Archilla A, Aneiros Cachaza J, Muñoz Medina M, Serrano Ortega S
Eur J Dermatol 2003 May-Jun;13(3):276-9. PMID: 12804989
Computed tomographic evaluation of lymph node metastasis in head and neck carcinomas.
Shingaki S, Suzuki I, Nakajima T, Hayashi T, Nakayama H, Nakamura M
J Craniomaxillofac Surg 1995 Aug;23(4):233-7. doi: 10.1016/s1010-5182(05)80213-6. PMID: 7560109

Therapy

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Exogenous Lipoid Pneumonia in Laryngectomy Patients: Radiological Findings.
García Latorre R, Rodríguez Díaz R, Barrios Barreto D, Ayala Carbonero A, García Gómez-Muriel MI, Gorospe Sarasúa L
Arch Bronconeumol 2015 Jul;51(7):e36-9. Epub 2014 Oct 23 doi: 10.1016/j.arbres.2014.09.002. PMID: 25446870
Solar cheilosis: an ominous precursor part II. Therapeutic perspectives.
Jadotte YT, Schwartz RA
J Am Acad Dermatol 2012 Feb;66(2):187-98; quiz 199-200. doi: 10.1016/j.jaad.2011.09.039. PMID: 22243722
Oral and oropharyngeal cancer, aryl hydrocarbon hydroxylase inducibility and smoking. A follow-up study.
Andréasson L, Björlin G, Laurell P, Trell E, Korsgaard R
ORL J Otorhinolaryngol Relat Spec 1985;47(3):131-8. doi: 10.1159/000275758. PMID: 4000652
Carcinoma of the lip.
Wurman LH, Adams GL, Meyerhoff WL
Am J Surg 1975 Oct;130(4):470-4. doi: 10.1016/0002-9610(75)90486-9. PMID: 1101725

Prognosis

Reconstruction of Tongue Defects With the Contralateral Nasolabial Island Flap.
Nueangkhota P, Liang YJ, Zheng GS, Su YX, Yang WF, Liao GQ
J Oral Maxillofac Surg 2016 Apr;74(4):851-9. Epub 2015 Oct 23 doi: 10.1016/j.joms.2015.10.013. PMID: 26549474
Multiple simultaneous primary oral squamous cell carcinomas: a previously unreported presentation.
Blythe JN, Brennan PA
Br J Oral Maxillofac Surg 2015 Sep;53(7):652-4. Epub 2015 May 21 doi: 10.1016/j.bjoms.2015.04.003. PMID: 26003797
Commissural localization of squamocellular carcinoma of the lip Our experience.
Chiummariello S, Del Torto G, Arleo S, Alfano C
Ann Ital Chir 2014 Sep-Oct;85(5):413-7. PMID: 25601012
Living with oral cancer: epidemiology with particular reference to prevalence and life-style changes that influence survival.
Warnakulasuriya S
Oral Oncol 2010 Jun;46(6):407-10. Epub 2010 Apr 18 doi: 10.1016/j.oraloncology.2010.02.015. PMID: 20403722
Markers of metastasis in lip cancer.
Fernández-Angel I, Rodríguez-Archilla A, Aneiros Cachaza J, Muñoz Medina M, Serrano Ortega S
Eur J Dermatol 2003 May-Jun;13(3):276-9. PMID: 12804989

Clinical prediction guides

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC).
Cohen EEW, Bell RB, Bifulco CB, Burtness B, Gillison ML, Harrington KJ, Le QT, Lee NY, Leidner R, Lewis RL, Licitra L, Mehanna H, Mell LK, Raben A, Sikora AG, Uppaluri R, Whitworth F, Zandberg DP, Ferris RL
J Immunother Cancer 2019 Jul 15;7(1):184. doi: 10.1186/s40425-019-0662-5. PMID: 31307547Free PMC Article
Nationwide Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England.
Venables ZC, Autier P, Nijsten T, Wong KF, Langan SM, Rous B, Broggio J, Harwood C, Henson K, Proby CM, Rashbass J, Leigh IM
JAMA Dermatol 2019 Mar 1;155(3):298-306. doi: 10.1001/jamadermatol.2018.4219. PMID: 30484823Free PMC Article
Squamous cell carcinoma of the lip: survival analysis with long-term follow-up.
Ozturk K, Gode S, Erdogan U, Akyildiz S, Apaydin F
Eur Arch Otorhinolaryngol 2015 Nov;272(11):3545-50. Epub 2014 Dec 3 doi: 10.1007/s00405-014-3415-6. PMID: 25467011
Bone scintigraphy: an aid in deciding on the extent of bone resection in malignant oral tumors.
Fischer-Brandies E, Seifert C
J Oral Maxillofac Surg 1995 Jul;53(7):768-70. doi: 10.1016/0278-2391(95)90328-3. PMID: 7595790
The island cheek flap: repair of cervical esophageal stricture and new extended indications.
Sasaki TM, Standage BA, Baker HW, McConnell DB, Vetto RM
Am J Surg 1984 May;147(5):650-3. doi: 10.1016/0002-9610(84)90133-8. PMID: 6721043

Recent systematic reviews

Immunohistochemical analysis of epithelium adjacent to lip cancer: A meta-analysis.
Varela-Centelles P, Gonzalez-Moles MÁ, Seoane-Romero J, Leira-Feijoo Y, Takkouche B, Seoane-Romero JM
Oral Dis 2022 Jan;28(1):57-65. Epub 2020 Oct 5 doi: 10.1111/odi.13643. PMID: 32945581
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Walsh T, Macey R, Kerr AR, Lingen MW, Ogden GR, Warnakulasuriya S
Cochrane Database Syst Rev 2021 Jul 20;7(7):CD010276. doi: 10.1002/14651858.CD010276.pub3. PMID: 34282854Free PMC Article
Diagnostic tests for oral cancer and potentially malignant disorders in patients presenting with clinically evident lesions.
Macey R, Walsh T, Brocklehurst P, Kerr AR, Liu JL, Lingen MW, Ogden GR, Warnakulasuriya S, Scully C
Cochrane Database Syst Rev 2015 May 29;2015(5):CD010276. doi: 10.1002/14651858.CD010276.pub2. PMID: 26021841Free PMC Article

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