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Series GSE63520 Query DataSets for GSE63520
Status Public on May 18, 2015
Title Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2 overexpression - implications for a combinatorial treatment
Organism Homo sapiens
Experiment type Expression profiling by array
Summary In this study we wanted to investigate the role of cIAP2 in drug resistance, the plausible mechanisms underlying this resistance and possible strategies to overcome this by combinatorial treatment in human MM cell lines containing a TRAF3 mutation
Overall design Gene expression profiling of the human MM cell line LP-1 under 6 different experimental perturbations: untreated or treated with bortezomib (10nM), 2 different timepoints (6 and 24 hours) and cIAP2 overexpression or endogenous cIAP2 level.
Contributor(s) Fristedt C, Agarwal P, Wiklund HJ
Citation(s) 26036313
Submission date Nov 20, 2014
Last update date Jan 09, 2018
Contact name Prasoon Agarwal
Organization name Rudbeck Laboratory, Uppsala University
Department IGP
Street address Dag Hammarshkojlds vag 20
City Uppsala
State/province Sweden
ZIP/Postal code 75185
Country Sweden
Platforms (1)
GPL17077 Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version)
Samples (16)
GSM1551481 LP-1-cIAP2-eGFP_untreated_6h rep1
GSM1551482 LP-1-cIAP2-eGFP untreated 24h rep1
GSM1551483 LP-1-cIAP2-eGFP bortezomib 10nM 6h rep1
BioProject PRJNA268107

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SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63520_RAW.tar 49.5 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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