|
| Status |
Public on May 18, 2015 |
| Title |
Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2 overexpression - implications for a combinatorial treatment |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In this study we wanted to investigate the role of cIAP2 in drug resistance, the plausible mechanisms underlying this resistance and possible strategies to overcome this by combinatorial treatment in human MM cell lines containing a TRAF3 mutation
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| |
|
| Overall design |
Gene expression profiling of the human MM cell line LP-1 under 6 different experimental perturbations: untreated or treated with bortezomib (10nM), 2 different timepoints (6 and 24 hours) and cIAP2 overexpression or endogenous cIAP2 level.
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| |
|
| Contributor(s) |
Fristedt C, Agarwal P, Wiklund HJ |
| Citation(s) |
26036313 |
| |
| Submission date |
Nov 20, 2014 |
| Last update date |
Jan 09, 2018 |
| Contact name |
Prasoon Agarwal |
| E-mail(s) |
helena.jernberg_wiklund@igp.uu.se
|
| Organization name |
Rudbeck Laboratory, Uppsala University
|
| Department |
IGP
|
| Street address |
Dag Hammarshkojlds vag 20
|
| City |
Uppsala |
| State/province |
Sweden |
| ZIP/Postal code |
75185 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL17077 |
Agilent-039494 SurePrint G3 Human GE v2 8x60K Microarray 039381 (Probe Name version) |
|
| Samples (16)
|
|
| Relations |
| BioProject |
PRJNA268107 |
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