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| Status |
Public on Nov 16, 2011 |
| Title |
Redefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by RT-PCR
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| Summary |
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types, in both in vitro and in vivo samples.
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| Overall design |
We studied 380 MDR genes, selected a priori based on an extensive curation of the literature published during the last three decades, in established cancer cell lines and clinical samples, either containing greater than 75% tumor cells or microdissected.
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| Contributor(s) |
Gillet J, Calcagno AM, Varma S, Marino M, Green L, Vora M, Patel C, Orina J, Eliseeva T, Singal V, Padmanabhan R, Davidson B, Ganapathi R, Sood A, Rueda B, Ambudkar SV, Gottesman MM |
| Citation(s) |
22068913 |
| |
| Submission date |
Jun 16, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
jean-pierre gillet |
| E-mail(s) |
jean-pierre.gillet@unamur.be
|
| Phone |
003281724275
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| Organization name |
University of Namur
|
| Department |
URPhyM
|
| Lab |
LMCB
|
| Street address |
61 Rue de Bruxelles
|
| City |
Namur |
| ZIP/Postal code |
5000 |
| Country |
Belgium |
| |
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| Platforms (2) |
| GPL13728 |
TaqMan qRT-PCR Homo sapiens Low-Density Array 380 |
| GPL14924 |
TaqMan qRT-PCR Homo sapiens Low-Density Array 380 v 2 |
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| Samples (228)
|
| GSM743327 |
Clinical sample, Colon-T2 |
| GSM743328 |
Clinical sample, Colon-N3 |
| GSM743329 |
Clinical sample, Colon-T3 |
| GSM743330 |
Clinical sample, Colon-N4 |
| GSM743331 |
Clinical sample, Colon-T4 |
| GSM743332 |
Clinical sample, Colon-N5 |
| GSM743333 |
Clinical sample, Colon-T5 |
| GSM743334 |
Clinical sample, Colon-N6 |
| GSM743335 |
Clinical sample, Colon-T6 |
| GSM743336 |
Clinical sample, Colon-N7 |
| GSM743337 |
Clinical sample, Colon-T7 |
| GSM743338 |
Clinical sample, GBM-P1 |
| GSM743339 |
Clinical sample, GBM-P2 |
| GSM743340 |
Clinical sample, GBM-P3 |
| GSM743341 |
Clinical sample, GBM-P4 |
| GSM743342 |
Clinical sample, GBM-R1 |
| GSM743343 |
Clinical sample, GBM-R2 |
| GSM743344 |
Clinical sample, GBM-R3 |
| GSM743345 |
Clinical sample, GBM-M1 |
| GSM743346 |
Clinical sample, GBM-M2 |
| GSM743347 |
Clinical sample, MM1 |
| GSM743348 |
Clinical sample, MM2 |
| GSM743349 |
Clinical sample, MM3 |
| GSM743350 |
Clinical sample, MM4 |
| GSM743351 |
Clinical sample, MM5 |
| GSM743352 |
Clinical sample, MM6 |
| GSM743353 |
Clinical sample, MM7 |
| GSM743354 |
Clinical sample, MM8 |
| GSM743355 |
Clinical sample, MM9 |
| GSM743356 |
Clinical sample, T-ALL1 |
| GSM743357 |
Clinical sample, T-ALL2 |
| GSM743358 |
Clinical sample, T-ALL3 |
| GSM743359 |
Clinical sample, T-ALL4 |
| GSM743360 |
Clinical sample, T-ALL5 |
| GSM743361 |
Clinical sample, T-ALL6 |
| GSM743362 |
Clinical sample, T-ALL7 |
| GSM743363 |
Clinical sample, T-ALL8 |
| GSM743364 |
Clinical sample, T-ALL9 |
| GSM743365 |
Clinical sample, T-ALL10 |
| GSM743366 |
Clinical sample, T-ALL11 |
| GSM743367 |
Clinical sample, T-ALL12 |
| GSM743368 |
Clinical sample, T-ALL13 |
| GSM743369 |
Clinical sample, T-ALL14 |
| GSM743370 |
Clinical sample, T-ALL15 |
| GSM743371 |
Clinical sample, T-ALL16 |
| GSM743372 |
Clinical sample, T-ALL17 |
| GSM743373 |
Clinical sample, T-ALL18 |
| GSM743374 |
Clinical sample, T-ALL19 |
| GSM743375 |
Clinical sample, T-ALL20 |
| GSM743376 |
Clinical sample, T-ALL21 |
| GSM743377 |
Clinical sample, T-ALL22 |
| GSM743378 |
Clinical sample, T-ALL23 |
| GSM743379 |
AML1D |
| GSM743380 |
AML1R |
| GSM743381 |
AML2D |
| GSM743382 |
AML2R |
| GSM743383 |
AML3D |
| GSM743384 |
AML3R |
| GSM743385 |
AML4D |
| GSM743386 |
AML4R |
| GSM743387 |
AML5D |
| GSM743388 |
AML5R |
| GSM743389 |
AML6D |
| GSM743390 |
AML6R |
| GSM743391 |
AML7D |
| GSM743392 |
AML7R |
| GSM743393 |
AML8D |
| GSM743394 |
AML8R |
| GSM743395 |
AML9D |
| GSM743396 |
AML9R |
| GSM743397 |
AML10D |
| GSM743398 |
AML10R |
| GSM743399 |
AML11D |
| GSM743400 |
AML11R |
| GSM743401 |
AML12D |
| GSM743402 |
AML13D |
| GSM743403 |
AML14D |
| GSM743404 |
AML15D |
| GSM743405 |
AML16D |
| GSM743406 |
AML17D |
| GSM743407 |
AML18D |
| GSM743408 |
AML19D |
| GSM743409 |
Kasumi 1 |
| GSM743410 |
HEL |
| GSM743411 |
UT-7 |
| GSM743412 |
ME-1 |
| GSM743413 |
U937 |
| GSM743414 |
TF-1 |
| GSM743415 |
Kasumi-6 |
| GSM743416 |
MO7e |
| GSM743417 |
MBO2 |
| GSM743435 |
Cell Line, CNS.SF.268 |
| GSM743436 |
Cell Line, CNS.SF.295 |
| GSM743437 |
Cell Line, CNS.SF.539 |
| GSM743438 |
Cell Line, CNS.SNB.19 |
| GSM743439 |
Cell Line, CNS.SNB.75 |
| GSM743440 |
Cell Line, CNS.U251 |
| GSM743441 |
Cell Line, CO.COLO205 |
| GSM743442 |
Cell Line, CO.HCC.2998 |
| GSM743443 |
Cell Line, CO.HCT.116 |
| GSM743444 |
Cell Line, CO.HCT.15 |
| GSM743445 |
Cell Line, CO.HT29 |
| GSM743446 |
Cell Line, CO.KM12 |
| GSM743447 |
Cell Line, CO.SW.620 |
| GSM743448 |
Cell Line, LC.A549 |
| GSM743449 |
Cell Line, LC.EKVX |
| GSM743450 |
Cell Line, LC.HOP.62 |
| GSM743451 |
Cell Line, LC.HOP.92 |
| GSM743452 |
Cell Line, LC.NCI.H226 |
| GSM743453 |
Cell Line, LC.NCI.H23 |
| GSM743454 |
Cell Line, LC.NCI.H322M |
| GSM743455 |
Cell Line, LC.NCI.H460 |
| GSM743456 |
Cell Line, LC.NCI.H522 |
| GSM743457 |
Cell Line, LE.CCRF.CEM |
| GSM743458 |
Cell Line, LE.HL.60 |
| GSM743459 |
Cell Line, LE.K.562 |
| GSM743460 |
Cell Line, LE.MOLT.4 |
| GSM743461 |
Cell Line, LE.RPMI.8226 |
| GSM743462 |
Cell Line, LE.SR |
| GSM743463 |
Cell Line, ME.LOXIMVI |
| GSM743464 |
Cell Line, ME.M14 |
| GSM743465 |
Cell Line, ME.MALME.3M |
| GSM743466 |
Cell Line, ME.MDA.MB.435 |
| GSM743467 |
Cell Line, ME.SK.MEL.2 |
| GSM743468 |
Cell Line, ME.SK.MEL.28 |
| GSM743469 |
Cell Line, ME.SK.MEL.5 |
| GSM743470 |
Cell Line, ME.UACC.257 |
| GSM743471 |
Cell Line, ME.UACC.62 |
| GSM743472 |
Cell Line, OV.IGROV1 |
| GSM743473 |
Cell Line, OV.NCI.ADR.RES |
| GSM743474 |
Cell Line, OV.OVCAR.3 |
| GSM743475 |
Cell Line, OV.OVCAR.4 |
| GSM743476 |
Cell Line, OV.OVCAR.5 |
| GSM743477 |
Cell Line, OV.OVCAR.8 |
| GSM743478 |
Cell Line, OV.SK.OV.3 |
| GSM743479 |
Cell Line, PR.DU.145 |
| GSM743480 |
Cell Line, PR.PC.3 |
| GSM743481 |
Cell Line, RE.A498 |
| GSM743482 |
Cell Line, RE.ACHN |
| GSM743483 |
Cell Line, RE.CAKI.1 |
| GSM743484 |
Cell Line, RE.RXF.393 |
| GSM743485 |
Cell Line, RE.SN12C |
| GSM743486 |
Cell Line, RE.TK.10 |
| GSM743487 |
Cell Line, RE.UO.31 |
| GSM743488 |
Cell Line, RE.786O |
| GSM743489 |
Cell Line, CL1 |
| GSM743490 |
Cell Line, CL2 |
| GSM743491 |
Cell Line, CL3 |
| GSM743492 |
Cell Line, CL4 |
| GSM743493 |
Cell Line, CL5 |
| GSM743494 |
Cell Line, CL6 |
| GSM743495 |
Cell Line, CL7 |
| GSM743496 |
Cell Line, CL8 |
| GSM743497 |
Cell Line, CL9 |
| GSM743498 |
Cell Line, CL10 |
| GSM743499 |
Cell Line, CL11 |
| GSM743500 |
Cell Line, CL12 |
| GSM743501 |
Cell Line, CL13 |
| GSM743502 |
Cell Line, CL14 |
| GSM743503 |
Cell Line, CL15 |
| GSM743504 |
Cell Line, CL16 |
| GSM743505 |
Cell Line, CL17 |
| GSM743506 |
Cell Line, CL18 |
| GSM743507 |
Cell Line, CL19 |
| GSM743508 |
Cell Line, CL20 |
| GSM743509 |
Cell Line, CL21 |
| GSM743510 |
Cell Line, CL22 |
| GSM743511 |
Cell Line, CL23 |
| GSM743512 |
Cell Line, CL24 |
| GSM743513 |
Cell Line, CL25 |
| GSM743514 |
Cell Line, CL26 |
| GSM743515 |
Cell Line, CL27 |
| GSM743516 |
Cell Line, CL28 |
| GSM743517 |
Cell Line, X1 |
| GSM743518 |
Cell Line, X2 |
| GSM743519 |
Cell Line, X3 |
| GSM743520 |
Cell Line, X4 |
| GSM743521 |
Cell Line, X5 |
| GSM743522 |
Cell Line, X6 |
| GSM743523 |
Cell Line, X7 |
| GSM743524 |
Cell Line, X8 |
| GSM743525 |
Normal ovarian tissue, N1 |
| GSM743526 |
Normal ovarian tissue, N2 |
| GSM743527 |
Normal ovarian tissue, N3 |
| GSM743528 |
Normal ovarian tissue, N4 |
| GSM743529 |
Normal ovarian tissue, N5 |
| GSM839031 |
Cell line, BT-549 |
| GSM839032 |
Cell line, HS578T |
| GSM839033 |
Cell line, MCF7 |
| GSM839034 |
Cell line, MDA-MB-231 |
| GSM839035 |
Cell line, T-47D |
| GSM839036 |
Cell line, CSC-R1 |
| GSM839037 |
Cell line, CSC-R2 |
| GSM839038 |
Cell line, Non CSC-R1 |
| GSM839039 |
Cell line, Non CSC-R2 |
| GSM839040 |
Cell line, MCF7 (ADR-sensitive) |
| GSM839041 |
Cell line, MCF7-ADR |
| GSM839042 |
Clinical sample, B-N1 |
| GSM839043 |
Clinical sample, B-N1 r1 133+ |
| GSM839044 |
Clinical sample, B-N1 r1 133- |
| GSM839045 |
Clinical sample, B-N1 r2 133+ |
| GSM839046 |
Clinical sample, B-N1 r2 133- |
| GSM839047 |
Clinical sample, B-N2 |
| GSM839048 |
Clinical sample, B-N2 133+ |
| GSM839049 |
Clinical sample, B-N2 133- |
| GSM839050 |
Clinical sample, B-N3 |
| GSM839051 |
Clinical sample, B-N3 133+ |
| GSM839052 |
Clinical sample, B-N4 |
| GSM839053 |
Clinical sample, B-N4 r1 133+ |
| GSM839054 |
Clinical sample, B-N4 r1 133- |
| GSM839055 |
Clinical sample, B-T1 133+ |
| GSM839056 |
Clinical sample, B-T1 |
| GSM839057 |
Clinical sample, B-T2 133+ |
| GSM839058 |
Clinical sample, B-T2 |
| GSM839059 |
Clinical sample, B-T3 |
| GSM839060 |
Clinical sample, B-T3 133+ |
| GSM839061 |
Clinical sample, B-T4 |
| GSM839062 |
Clinical sample, B-T5 r1 |
| GSM839063 |
Clinical sample, B-T5 r2 |
| GSM839064 |
Clinical sample, B-T5 r1 133+ |
| GSM839065 |
Clinical sample, B-T5 r2 133+ |
| GSM839066 |
Clinical sample, B-T6 |
| GSM839067 |
Clinical sample, B-T6 133+ |
| GSM839068 |
Clinical sample, B-T6 133- |
| GSM839069 |
Clinical sample, B-T7 |
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| Relations |
| BioProject |
PRJNA144059 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30034_GSM839031_to_GSM839069_raw_Ct_values.txt.gz |
22.9 Kb |
(ftp)(http) |
TXT |
| GSE30034_raw_Ct_values.txt.gz |
120.5 Kb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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