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Series GSE203241 Query DataSets for GSE203241
Status Public on May 15, 2024
Title Age-related blood transcriptional regulators affect disease progression in pediatric multiple sclerosis
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The more aggressive clinical disease course of Pediatric Onset Multiple Sclerosis(POMS) as compared to Adult Onset Multiple Sclerosis(AOMS) during the first year disease is supported by higher inflammatory potential promoted by transcriptional level of age-associated genes and transcription factors involved in Cell Cycle, B Cell proliferation and senescent mechanisms.
Herein, we compared the blood mononuclear cell transcriptome of POMS and AOMS patients during first year disease. Pediatric Healthy and Adult subjects (PHC, AHC) were used as controls. Correlation analysis of the gene expression with the radiological sign, upstream regulators analysis and clinical assesment were also evaluated.
Overall design A total of 38 MS patients (22 POMS and 16 AOMS) and 21 Healthy controls( 11 PHC and 10 AHC) were analyzed.
Contributor(s) Shavit E, Menascu S, Achiron A, Gurevich M
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Submission date May 18, 2022
Last update date May 15, 2024
Contact name Michael Gurevich
Organization name Sheba Medical Center
Department Multiple Sclerosis Center
Lab Neurogenomics and Neuroimmunology
Street address Tel Hashomer
City Ramat Gan
ZIP/Postal code 52621
Country Israel
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (59)
GSM6165173 POMS [1815OUT98]
GSM6165174 POMS [5152OUT99]
GSM6165175 POMS [4374ONCIS150]
BioProject PRJNA839242

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE203241_RAW.tar 108.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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