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Series GSE141656 Query DataSets for GSE141656
Status Public on Dec 10, 2019
Title Transcriptomes of human trained macrophages before and after Mtb exposure
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary Trained Immunity (TRIM) is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to specific microbial or metabolic components. In this study, monocytes were trained with beta-glucan and then re-exposed to Mycobacterium tuberculosis.
Overall design In this study human monocytes were exposed to beta-glucan for 24 hours in vitro, a stimulus that induced TRIM, and were then differentiated to macrophages for another 5 days. At day 6, trained and not-trained macrophages were exposed to Mycobacterium tuberculosis (Mtb) for 4 hours and their transcriptomes were profiled .
Contributor(s) Moorlag S, Novakovic B, Netea M
Citation(s) 32433977
Submission date Dec 09, 2019
Last update date Mar 20, 2023
Contact name Boris Novakovic
Phone 0434980073
Organization name Murdoch Children's Research Institute
Street address Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road
City Parkville
State/province Victoria
ZIP/Postal code 3052
Country Australia
Platforms (1)
GPL24676 Illumina NovaSeq 6000 (Homo sapiens)
Samples (12)
GSM4210633 A_BG_MTB
GSM4210634 A_BG_RPMI
BioProject PRJNA594316
SRA SRP235239

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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE141656_RAW.tar 28.6 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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