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| Status |
Public on Apr 01, 2012 |
| Title |
Estrogen Regulates the JNK1 Genomic Localization Program in Breast Cancer Cells to Control Gene Expression and Cell Growth |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by genome tiling array
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| Summary |
JNK1 ChIP-chip and ER-alpha ChIP-chip were performed on NimbleGen genomic tiling arrays to understand the genomic binding patterns of this MAP kinase and receptor and their relationship to gene expression.
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| Overall design |
ChIP-chip analysis of JNK1 occupancy at promoters before and after estrogen treatment. 2 biological replicates (rep1 and rep2, rep3A and rep3B), 2 technical replicates each.
ChIP-chip analysis of ER-alpha occupancy at promoters before and after estrogen treatment. 2 biological replicates, 2 technical replicates for one of the replicates (1 and 2).
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| Contributor(s) |
Sun M, Isaacs GD, Hah N, Heldring N, Fogarty EA, Kraus WL |
| Citation(s) |
22446103 |
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| Submission date |
Oct 14, 2008 |
| Last update date |
Sep 21, 2012 |
| Contact name |
W. Lee Kraus |
| E-mail(s) |
lee.kraus@utsouthwestern.edu
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| Organization name |
UT Southwestern Medical Center
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| Street address |
5323 Harry Hines Blvd.
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| City |
Dallas |
| State/province |
TX |
| ZIP/Postal code |
75390-8511 |
| Country |
USA |
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| Platforms (3) |
| GPL7485 |
Homo sapiens 389K Hg18 RefSeq promoter |
| GPL13752 |
Human_HG18_Deluxe_Promoter_HX1_HD2.1 tiling array |
| GPL13756 |
Human_HG18_Deluxe_Promoter_HX1_HD2.2 tiling array |
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| Samples (12)
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| GSM333361 |
JNK1-U3B, untreated, rep3 (2 of 2) |
| GSM333362 |
JNK1-E1, estrogen treated, rep1 |
| GSM333363 |
JNK1-E2, estrogen treated, rep2 |
| GSM333364 |
JNK1-E3A, estrogen treated, rep3 (1 of 2) |
| GSM333365 |
JNK1-E3B, estrogen treated, rep3 (2 of 2) |
| GSM745965 |
ER-alpha ChIP, estrogen treated, technical rep1 and rep2 |
| GSM745966 |
ER-alpha ChIP, untreated, technical rep1 and rep2 |
| GSM745989 |
ER-alpha ChIP, untreated, rep3 |
| GSM745994 |
ER-alpha ChIP, estrogen treated, rep3 |
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| Relations |
| BioProject |
PRJNA109499 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE13200_RAW.tar |
966.9 Mb |
(http)(custom) |
TAR (of PAIR, TXT) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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