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| Status |
Public on Jul 17, 2019 |
| Title |
A retained transcriptomic profile characterizes the CD138+ cells in the progression from smoldering to active multiple myeloma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Smoldering myeloma (SMM) is a pre-malignant monoclonal gammopathy with a 10% annual risk to progress to active multiple myeloma (MM). SMM diagnostic criteria, as well of those of others monoclonal gammopathies, have been updated by the International Myeloma Working Group (IMWG) in 2014. In particular, the previously defined “ultra high-risk” SMM (characterized by the presence of specific biomarkers associated with a ≥ 80% risk of progression to symptomatic MM within 2 years) has been included among patients with active MM. SMM is biologically heterogeneous, including a subset of patients with biological pre-malignancy and a subset with biological malignancy who have not yet developed organ damage, defined as onset of the classical CRAB criteria or Myeloma Defining Events (MDE). Thus, SMM encompassed patients with a very low rate of progression to symptomatic MM, similar to patients with monoclonal gammopathy of uncertain significance (MGUS), as well as patients who acquired organ damage and progress to active MM within the first year from diagnosis. The molecular mechanisms involved in the SMM to MM progression are still far to be fully understood. Genomic studies indicate that the genetic alterations that characterize MM patients are already present in SMM ones, who present similar mutational and copy number alteration load. However, few data are available on the transcriptional profiles of SMM patients in relationship to the progression to active MM, overall indicating minimal differential expression either in coding or non-coding RNA fraction. To date, robust data are still lacking which describe the transcriptional profiles of plasma cells (PCs) from paired samples obtained at the time of SMM and at MM onset. Herein, we compared the transcriptome of purified CD138+ PCs from paired samples of SMM patients progressed to active MM (P-SMM), aimed at describing any possible common transcriptional discrepancy that may help to understand the intra-patient disease evolution; at the same time, we investigated the transcriptional differences between P-SMM and a subset of non-progressed SMM (NP-SMM) at a minimum of 36 months.
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| Overall design |
A total number of 20 SMM patients, admitted to the Hematological Unit of our Institution over the last 11 years, were considered: 12 non-progressed(NP)-SMM and 8 progressed(P)-SMM for whom paired active MM samples were available
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| Contributor(s) |
Storti P, Agnelli L, Della Palma B, Todoerti K, Marchica V, Accardi F, Deluca F, Bolzoni M, Craviotto L, Aversa F, Neri A, Giuliani N |
| Citation(s) |
30846495, 32218309 |
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| Submission date |
Jul 30, 2018 |
| Last update date |
May 26, 2020 |
| Contact name |
Luca Agnelli |
| E-mail(s) |
luca.agnelli@istitutotumori.mi.it, luca.agnelli@gmail.com
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| Phone |
+390223903581
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| Organization name |
IRCCS Istituto Nazionale dei Tumori
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| Department |
Department of Advanced Diagnostics
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| Street address |
Venezian 1
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| City |
MILAN |
| ZIP/Postal code |
20133 |
| Country |
Italy |
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| Platforms (1) |
| GPL25401 |
[Clariom_D_Human] Affymetrix Human Clariom D Assay [CDF: Brainarray ClariomDHuman_Hs_GENECODEG_22.0.0] |
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| Samples (32)
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| GSM3310601 |
MM progressed from paired sample 10 |
| GSM3310602 |
SMM at diagnosis, sample 9 |
| GSM3310603 |
SMM at diagnosis, sample 5 |
| GSM3310604 |
SMM at diagnosis, sample 2 |
| GSM3310605 |
SMM at diagnosis, non-progressed sample 3 |
| GSM3310606 |
SMM at diagnosis, sample 4 |
| GSM3310607 |
MM progressed from paired sample 7 |
| GSM3310608 |
SMM at diagnosis, non-progressed sample 4 |
| GSM3310609 |
SMM at diagnosis, sample 8 |
| GSM3310610 |
MM progressed from paired sample 9 |
| GSM3310611 |
MM progressed from paired sample 5 |
| GSM3310612 |
SMM at diagnosis, sample 1 |
| GSM3310613 |
MM progressed from paired sample 2 |
| GSM3310614 |
SMM at diagnosis, non-progressed sample 5 |
| GSM3310615 |
MM progressed from paired sample 1 |
| GSM3310616 |
SMM at diagnosis, sample 3 |
| GSM3310617 |
SMM at diagnosis, sample 6 |
| GSM3310618 |
MM progressed from paired sample 3 |
| GSM3310619 |
SMM at diagnosis, non-progressed sample 6 |
| GSM3310620 |
SMM at diagnosis, non-progressed sample 7 |
| GSM3310621 |
SMM at diagnosis, non-progressed sample 8 |
| GSM3310622 |
SMM at diagnosis, non-progressed sample 9 |
| GSM3310623 |
SMM at diagnosis, non-progressed sample 10 |
| GSM3310624 |
MM progressed from paired sample 8 |
| GSM3310625 |
SMM at diagnosis, non-progressed sample 11 |
| GSM3310626 |
SMM at diagnosis, non-progressed sample 12 |
| GSM3310627 |
MM progressed from paired sample 4 |
| GSM3310628 |
MM progressed from paired sample 6 |
| GSM3310629 |
SMM at diagnosis, sample 7 |
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| Relations |
| BioProject |
PRJNA483417 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE117847_RAW.tar |
834.9 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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