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Zfp78 zinc finger protein 78 [ Mus musculus (house mouse) ]

Gene ID: 330463, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp78provided by MGI
Official Full Name
zinc finger protein 78provided by MGI
Primary source
MGI:MGI:107783
See related
Ensembl:ENSMUSG00000055150 AllianceGenome:MGI:107783
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp77; KRAB12; A330079D15
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF471 (zinc finger protein 471). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zfp78 in Genome Data Viewer
Location:
7 A1; 7 3.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6365812..6385605)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6362809..6382606)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 583 Neighboring gene predicted gene, 38944 Neighboring gene zinc finger protein 582 Neighboring gene STARR-positive B cell enhancer ABC_E8944 Neighboring gene STARR-positive B cell enhancer ABC_E442 Neighboring gene STARR-seq mESC enhancer starr_17978 Neighboring gene STARR-positive B cell enhancer ABC_E8150 Neighboring gene predicted gene, 53349 Neighboring gene zinc finger protein 28 Neighboring gene small integral membrane protein 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  3. Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci. Marine JC, et al. Mamm Genome, 1996 Jun. PMID 8662221
  4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC102644

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 471

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025163.1 → NP_001020334.1  zinc finger protein 471 isoform 1

    See identical proteins and their annotated locations for NP_001020334.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK173164, BB603663, BY768295
    Consensus CDS
    CCDS20774.1
    UniProtKB/TrEMBL
    Q5U406
    Related
    ENSMUSP00000147154.2, ENSMUST00000207347.2
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:202 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001112805.1 → NP_001106276.1  zinc finger protein 471 isoform 2

    See identical proteins and their annotated locations for NP_001106276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK163133, AK173164, BB603663
    Consensus CDS
    CCDS20775.1
    UniProtKB/TrEMBL
    Q8BJ21
    Related
    ENSMUSP00000147228.2, ENSMUST00000208390.2
    Conserved Domains (3) summary
    COG5048
    Location:170 → 455
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:231 → 251
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 54
    KRAB; KRAB box

  3. NM_177888.4 → NP_808556.1  zinc finger protein 471 isoform 2

    See identical proteins and their annotated locations for NP_808556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the 5' UTR but lacks a coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK039658, AK173164, BB603663
    Consensus CDS
    CCDS20775.1
    UniProtKB/TrEMBL
    Q8BJ21
    Related
    ENSMUSP00000146592.2, ENSMUST00000208030.2
    Conserved Domains (3) summary
    COG5048
    Location:170 → 455
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:231 → 251
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 54
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6365812..6385605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540100.5 → XP_006540163.1  zinc finger protein 471 isoform X2

    See identical proteins and their annotated locations for XP_006540163.1

    UniProtKB/TrEMBL
    Q8BJ21
    Related
    ENSMUSP00000146578.2, ENSMUST00000207314.2
    Conserved Domains (3) summary
    COG5048
    Location:170 → 455
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:231 → 251
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 54
    KRAB; KRAB box

  2. XM_017322306.3 → XP_017177795.1  zinc finger protein 471 isoform X1

    UniProtKB/TrEMBL
    Q5U406
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:202 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030242686.2 → XP_030098546.1  zinc finger protein 471 isoform X1

    UniProtKB/TrEMBL
    Q5U406
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:202 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_017322307.3 → XP_017177796.1  zinc finger protein 471 isoform X1

    UniProtKB/TrEMBL
    Q5U406
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:202 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036153176.1 → XP_036009069.1  zinc finger protein 471 isoform X1

    UniProtKB/TrEMBL
    Q5U406
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:202 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:263 → 283
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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