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Conserved domains on  [gi|68448539|ref|NP_001020334|]
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zinc finger protein 471 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539     14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048 270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                ....*
gi 68448539 483 RPYVC 487
Cdd:COG5048 350 SPAKE 354
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539     14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.04e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 68448539    14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.90e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.90e-17
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 68448539  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048 270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                ....*
gi 68448539 483 RPYVC 487
Cdd:COG5048 350 SPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 68448539   415 YLARHQKIHTGEKPYECNECGKTFTH 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539     14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.04e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 68448539    14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.90e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.90e-17
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 68448539  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048 270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                ....*
gi 68448539 483 RPYVC 487
Cdd:COG5048 350 SPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-365 4.49e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 203 TIFKCNECEKTFTHSSAVTVHQR--IHTGE--KPYQCTV--CGKAFKQSHHLAQHHTTHTHEKLFQC--EECKKAFSQ-- 272
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 273 NSYLTVHRRIHTGEKPYKCKECAKSFRQPA----HLAQHHRIHT---GEKPYKCEICGKAFNHSMSLTGHQRVHSGEKPY 345
Cdd:COG5048 368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNfkrdSNLSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170       180
                ....*....|....*....|
gi 68448539 346 KCKDCGKaFRQSIHLVVHSR 365
Cdd:COG5048 448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-470 7.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 7.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 291 CKECAKSFRQPAHLAQHHRIHTGE-------KPYKCEICGKAFNHSMSLTGHQR--VHSGE--KPYKC--KDCGKAFRQS 357
Cdd:COG5048 257 ASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 358 IHLVVHSRIHTGEEPYEC--NECGKTFRESS-----QLTIHQRNHTGEKPFEC--KQCGKFFNRSAYLARHQKIHTGEKP 428
Cdd:COG5048 337 DALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 68448539 429 YECN--ECGKTFTHAAYLIRHKRVHTGEKPYKCAECGKAFGDGS 470
Cdd:COG5048 417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-413 3.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 259 KLFQCEECKKAFSQNSYLTVHRR--IHTGE--KPYKCKE--CAKSFRQPAHLAQHHRIHTGEKPYKC--EICGKAFNHS- 329
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLl 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 330 -MSLTGHQRVHSGEKPYKCK-----DCGKAFRQSIHLVVHSRIHTGEEPYECN--ECGKTFRESSQLTIHQRNHTGEKPF 401
Cdd:COG5048 368 nNEPPQSLQQYKDLKNDKKSetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|..
gi 68448539 402 ECKQCGKFFNRS 413
Cdd:COG5048 448 LCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
427-492 2.99e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.99e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 68448539 427 KPYECNECGKTFTHAAYLIRHKRVHTGEKPYKCA--ECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 492
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 68448539   415 YLARHQKIHTGEKPYECNECGKTFTH 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 2.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 68448539   303 HLAQHHRIHTGEKPYKCEICGKAFNH 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-466 4.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....
gi 68448539   443 YLIRHKRVHTGEKPYKCAECGKAF 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-244 8.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.06e-04
                          10        20
                  ....*....|....*....|..
gi 68448539   223 HQRIHTGEKPYQCTVCGKAFKQ 244
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 68448539   275 YLTVHRRIHTGEKPYKCKECAKSFRQ 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-412 3.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*
gi 68448539   388 LTIHQRNHTGEKPFECKQCGKFFNR 412
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 415-508 3.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68448539 415 YLARHQKIhTGEKPYECN--ECGKTFTHAAYLIRHKrvhtgekpyKCAECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 492
Cdd:COG5189 337 TPSRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406

                        90
                ....*....|....*.
gi 68448539 493 AFRRKSSLNCHQRYHT 508
Cdd:COG5189 407 RYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-356 6.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.34e-03
                          10        20
                  ....*....|....*....|..
gi 68448539   335 HQRVHSGEKPYKCKDCGKAFRQ 356
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 8.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....
gi 68448539   359 HLVVHSRIHTGEEPYECNECGKTF 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 9.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.62e-03
                          10        20
                  ....*....|....*....|...
gi 68448539   429 YECNECGKTFTHAAYLIRHKRVH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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