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Conserved domains on  [gi|1907182045|ref|XP_036009069|]
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zinc finger protein 471 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                  ....*
gi 1907182045 483 RPYVC 487
Cdd:COG5048   350 SPAKE 354
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.04e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907182045  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.90e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.90e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907182045  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                  ....*
gi 1907182045 483 RPYVC 487
Cdd:COG5048   350 SPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907182045 415 YLARHQKIHTGEKPYECNECGKTFTH 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-73 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 1.77e-30
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGACISKPSLISLLEHGKEPW 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.04e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 3.04e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907182045  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.90e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.90e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907182045  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-487 1.41e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 202 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 273
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 274 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 335
Cdd:COG5048   111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 336 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 415
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 416 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 482
Cdd:COG5048   270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                  ....*
gi 1907182045 483 RPYVC 487
Cdd:COG5048   350 SPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-365 4.49e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 203 TIFKCNECEKTFTHSSAVTVHQR--IHTGE--KPYQCTV--CGKAFKQSHHLAQHHTTHTHEKLFQC--EECKKAFSQ-- 272
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 273 NSYLTVHRRIHTGEKPYKCKECAKSFRQPA----HLAQHHRIHT---GEKPYKCEICGKAFNHSMSLTGHQRVHSGEKPY 345
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNfkrdSNLSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170       180
                  ....*....|....*....|
gi 1907182045 346 KCKDCGKaFRQSIHLVVHSR 365
Cdd:COG5048   448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
291-470 7.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 7.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 291 CKECAKSFRQPAHLAQHHRIHTGE-------KPYKCEICGKAFNHSMSLTGHQR--VHSGE--KPYKC--KDCGKAFRQS 357
Cdd:COG5048   257 ASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 358 IHLVVHSRIHTGEEPYEC--NECGKTFRESS-----QLTIHQRNHTGEKPFEC--KQCGKFFNRSAYLARHQKIHTGEKP 428
Cdd:COG5048   337 DALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1907182045 429 YECN--ECGKTFTHAAYLIRHKRVHTGEKPYKCAECGKAFGDGS 470
Cdd:COG5048   417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-413 3.00e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 3.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 259 KLFQCEECKKAFSQNSYLTVHRR--IHTGE--KPYKCKE--CAKSFRQPAHLAQHHRIHTGEKPYKC--EICGKAFNHS- 329
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLl 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 330 -MSLTGHQRVHSGEKPYKCK-----DCGKAFRQSIHLVVHSRIHTGEEPYECN--ECGKTFRESSQLTIHQRNHTGEKPF 401
Cdd:COG5048   368 nNEPPQSLQQYKDLKNDKKSetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|..
gi 1907182045 402 ECKQCGKFFNRS 413
Cdd:COG5048   448 LCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
427-492 2.99e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.99e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907182045 427 KPYECNECGKTFTHAAYLIRHKRVHTGEKPYKCA--ECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 492
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 1.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907182045 415 YLARHQKIHTGEKPYECNECGKTFTH 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 2.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907182045 303 HLAQHHRIHTGEKPYKCEICGKAFNH 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-466 4.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....
gi 1907182045 443 YLIRHKRVHTGEKPYKCAECGKAF 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-244 8.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.06e-04
                          10        20
                  ....*....|....*....|..
gi 1907182045 223 HQRIHTGEKPYQCTVCGKAFKQ 244
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-300 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907182045 275 YLTVHRRIHTGEKPYKCKECAKSFRQ 300
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-412 3.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.45e-03
                          10        20
                  ....*....|....*....|....*
gi 1907182045 388 LTIHQRNHTGEKPFECKQCGKFFNR 412
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 415-508 3.81e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907182045 415 YLARHQKIhTGEKPYECN--ECGKTFTHAAYLIRHKrvhtgekpyKCAECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 492
Cdd:COG5189   337 TPSRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406

                          90
                  ....*....|....*.
gi 1907182045 493 AFRRKSSLNCHQRYHT 508
Cdd:COG5189   407 RYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-356 6.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.34e-03
                          10        20
                  ....*....|....*....|..
gi 1907182045 335 HQRVHSGEKPYKCKDCGKAFRQ 356
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-382 8.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....
gi 1907182045 359 HLVVHSRIHTGEEPYECNECGKTF 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 9.62e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.62e-03
                          10        20
                  ....*....|....*....|...
gi 1907182045 429 YECNECGKTFTHAAYLIRHKRVH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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