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Conserved domains on  [gi|163914384|ref|NP_001106276|]
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zinc finger protein 471 isoform 2 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 163914384   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-455 3.36e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 170 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 241
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 242 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 303
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 304 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 383
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 384 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 450
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                 ....*
gi 163914384 451 RPYVC 455
Cdd:COG5048  350 SPAKE 354
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 163914384   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-68 7.07e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.72  E-value: 7.07e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 163914384    14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGGKsVQKTHELSLRQ 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-VPKPDLISQLE 54
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.62e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.62e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 163914384  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-455 3.36e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 170 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 241
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 242 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 303
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 304 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 383
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 384 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 450
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                 ....*
gi 163914384 451 RPYVC 455
Cdd:COG5048  350 SPAKE 354
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 163914384  383 YLARHQKIHTGEKPYECNECGKTFTH 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 2.71e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 2.71e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 163914384   14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-68 7.07e-21

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 85.72  E-value: 7.07e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 163914384    14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVSVGGKsVQKTHELSLRQ 68
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ-VPKPDLISQLE 54
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-52 3.62e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 3.62e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 163914384  14 VTFNDVAIDFSPEEWDWLNPAQRSLYRTVVLENYRNLVS 52
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-455 3.36e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 170 KTIFKCNECEKTFTHSSAVTVHQRIHTGEKPYQCTVCGKAFKQS-----HHLAQHHTT---HTHEKLFQCEECKKAFSQN 241
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplelSRHLRTHHNnpsDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 242 SYLTVHRRIHTGEKPYKCK----------ECAKSFRQPAHLAQHHRIHTGEKPYKC--------EICGKAFNHSMSLTGH 303
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPpssrdpqlpdLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 304 QRVHSGEKPYKCKDCGKAFRQSIHLVVHSRIHTgEEPYECNECGKTFRESSQLTIHQRNHTGEKPFECKQCGKFFNRSAY 383
Cdd:COG5048  191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 384 LARHQKIHTGE-------KPYECNECGKTFTHAAYLIRHKR--VHTGE--KPYKCAE--CGKAFGDGSSRAQHQRLHTGQ 450
Cdd:COG5048  270 SQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349


                 ....*
gi 163914384 451 RPYVC 455
Cdd:COG5048  350 SPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-333 9.55e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.40  E-value: 9.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 171 TIFKCNECEKTFTHSSAVTVHQR--IHTGE--KPYQCTV--CGKAFKQSHHLAQHHTTHTHEKLFQC--EECKKAFSQ-- 240
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 241 NSYLTVHRRIHTGEKPYKCKECAKSFRQPA----HLAQHHRIHT---GEKPYKCEICGKAFNHSMSLTGHQRVHSGEKPY 313
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSNSCIRNfkrdSNLSLHIITHlsfRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170       180
                 ....*....|....*....|
gi 163914384 314 KCKDCGKaFRQSIHLVVHSR 333
Cdd:COG5048  448 LCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
259-438 1.37e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 259 CKECAKSFRQPAHLAQHHRIHTGE-------KPYKCEICGKAFNHSMSLTGHQR--VHSGE--KPYKC--KDCGKAFRQS 325
Cdd:COG5048  257 ASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRN 336

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 326 IHLVVHSRIHTGEEPYEC--NECGKTFRESS-----QLTIHQRNHTGEKPFEC--KQCGKFFNRSAYLARHQKIHTGEKP 396
Cdd:COG5048  337 DALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 163914384 397 YECN--ECGKTFTHAAYLIRHKRVHTGEKPYKCAECGKAFGDGS 438
Cdd:COG5048  417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-381 5.69e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 5.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 227 KLFQCEECKKAFSQNSYLTVHRR--IHTGE--KPYKCKE--CAKSFRQPAHLAQHHRIHTGEKPYKC--EICGKAFNHS- 297
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLl 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 298 -MSLTGHQRVHSGEKPYKCK-----DCGKAFRQSIHLVVHSRIHTGEEPYECN--ECGKTFRESSQLTIHQRNHTGEKPF 369
Cdd:COG5048  368 nNEPPQSLQQYKDLKNDKKSetlsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|..
gi 163914384 370 ECKQCGKFFNRS 381
Cdd:COG5048  448 LCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
395-460 4.16e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 4.16e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 163914384 395 KPYECNECGKTFTHAAYLIRHKRVHTGEKPYKCA--ECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 460
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*.
gi 163914384  383 YLARHQKIHTGEKPYECNECGKTFTH 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 3.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 163914384  271 HLAQHHRIHTGEKPYKCEICGKAFNH 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-434 6.10e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.10e-04
                          10        20
                  ....*....|....*....|....
gi 163914384  411 YLIRHKRVHTGEKPYKCAECGKAF 434
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
191-212 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.18e-03
                          10        20
                  ....*....|....*....|..
gi 163914384  191 HQRIHTGEKPYQCTVCGKAFKQ 212
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
243-268 2.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 163914384  243 YLTVHRRIHTGEKPYKCKECAKSFRQ 268
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 383-476 4.45e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 163914384 383 YLARHQKIhTGEKPYECN--ECGKTFTHAAYLIRHKrvhtgekpyKCAECGKAFGDGSSRAQHQRLHTGQRPYVCEKCGR 460
Cdd:COG5189  337 TPSRMLKV-KDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDK 406

                         90
                 ....*....|....*.
gi 163914384 461 AFRRKSSLNCHQRYHT 476
Cdd:COG5189  407 RYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*
gi 163914384  356 LTIHQRNHTGEKPFECKQCGKFFNR 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-324 8.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.99e-03
                          10        20
                  ....*....|....*....|..
gi 163914384  303 HQRVHSGEKPYKCKDCGKAFRQ 324
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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