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Slc12a4 solute carrier family 12 member 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 29501, updated on 17-Aug-2024

Summary

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Official Symbol
Slc12a4provided by RGD
Official Full Name
solute carrier family 12 member 4provided by RGD
Primary source
RGD:3687
See related
EnsemblRapid:ENSRNOG00000019651 AllianceGenome:RGD:3687
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kcc1
Summary
Predicted to enable potassium:chloride symporter activity and protein kinase binding activity. Predicted to be involved in several processes, including cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to be located in synapse. Predicted to be integral component of membrane. Orthologous to human SLC12A4 (solute carrier family 12 member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 124.9), Heart (RPKM 120.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50748268..50770217, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (33838418..33860369, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (37917003..37938952, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit beta 10 Neighboring gene lecithin cholesterol acyltransferase Neighboring gene uncharacterized LOC120098640 Neighboring gene dipeptidase 3 Neighboring gene dipeptidase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Routes of epithelial water flow: aquaporins versus cotransporters. Mollajew R, et al. Biophys J, 2010 Dec 1. PMID 21112289, Free PMC Article
  2. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. Payne JA, et al. J Biol Chem, 1996 Jul 5. PMID 8663311
  3. Chloride accumulation in mammalian olfactory sensory neurons. Kaneko H, et al. J Neurosci, 2004 Sep 8. PMID 15356206, Free PMC Article
  4. Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase. Inoue K, et al. FEBS Lett, 2004 Apr 23. PMID 15094054
  5. Expression of K+-Cl- cotransporters in the alpha-cells of rat endocrine pancreas. Davies SL, et al. Biochim Biophys Acta, 2004 Nov 17. PMID 15533301

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium:chloride symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium:chloride symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 4
Names
electroneutral potassium-chloride cotransporter 1
erythroid K-Cl cotransporter 1
furosemide-sensitive K-Cl cotransporter
rKCC1
solute carrier family 12 (potassium/chloride transporter), member 4
solute carrier family 12 (potassium/chloride transporters), member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019229.2 → NP_062102.1  solute carrier family 12 member 4

    See identical proteins and their annotated locations for NP_062102.1

    Status: PROVISIONAL

    Source sequence(s)
    U55815
    UniProtKB/Swiss-Prot
    P70632, Q63632
    UniProtKB/TrEMBL
    A6IYV0
    Related
    ENSRNOP00000026730.3, ENSRNOT00000026730.6
    Conserved Domains (3) summary
    TIGR00930
    Location:42 → 1085
    2a30; K-Cl cotransporter
    pfam03522
    Location:709 → 1085
    SLC12; Solute carrier family 12
    cl00456
    Location:142 → 303
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50748268..50770217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772492.4 → XP_008770714.1  solute carrier family 12 member 4 isoform X3

    Conserved Domains (3) summary
    TIGR00930
    Location:63 → 1080
    2a30; K-Cl cotransporter
    pfam03522
    Location:704 → 1080
    SLC12; Solute carrier family 12
    cl00456
    Location:137 → 298
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_006255482.5 → XP_006255544.1  solute carrier family 12 member 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKL7
    Related
    ENSRNOP00000078286.1, ENSRNOT00000095105.2
    Conserved Domains (3) summary
    TIGR00930
    Location:11 → 1054
    2a30; K-Cl cotransporter
    pfam03522
    Location:678 → 1054
    SLC12; Solute carrier family 12
    cl00456
    Location:111 → 272
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  3. XM_039097677.2 → XP_038953605.1  solute carrier family 12 member 4 isoform X2

    Conserved Domains (1) summary
    TIGR00930
    Location:42 → 583
    2a30; K-Cl cotransporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63632.1 GenPept UniProtKB/Swiss-Prot:Q63632

Gene LinkOut

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