GEO DataSets

(Submitter supplied) Obesity is recognized as a risk factor for triggering rheumatoid arthritis (RA), and it can worsen joint deformities and diminish the quality of life in patients with RA. The reduction of body weight in obese individuals is believed to alleviate RA symptoms。

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28457

11 Samples

Download data: XLS

(Submitter supplied) Autoimmune diseases, such as rheumatoid arthritis, are associated with significant gut microbiota dysbiosis. Here we show that remodelling of 24h rhythms within the gut during inflammatory joint disease drives profound changes in the microbiome and gut permeability.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

60 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL24247 GPL24676

154 Samples

Download data

(Submitter supplied) Additive effects of anti-TNF and anti-IL-6 were evaluated in a murine collagen-induced arthritis (CIA) model by RNA-seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

56 Samples

Download data: TXT

(Submitter supplied) Gene expression profiles in the gut of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32762

1 Sample

Download data: XLS

(Submitter supplied) Gene expression profiles in the spine of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32762

1 Sample

Download data: XLS

(Submitter supplied) Gene expression profiles in the tarsal joints of DBA/1 mice whit spontaneus arthritis and treated with levofloxacion vs. those who were not received levofloxacin were compared. Levofloxacin induced the downexpression of inflammation-related genes and signaling pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32762

1 Sample

Download data: XLS

(Submitter supplied) Gene expression profiles in the tarsal joints of DBA/1 mice whit collagen-induced arthritis that performed treadmill exercise in the post-arthritic phase vs. those who were not exercised were compared. Exercise induced the upregulation of inflammatory genes and signaling pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32606

1 Sample

Download data: XLS

(Submitter supplied) Gene expression profiles in the tarsal joints of DBA/1 mice whit collagen-induced arthritis that performed treadmill exercise in the pre-arthritic phase vs. those who were not exercised were compared. Exercise induced the downregulation of inflammatroy genes and signaling pathways.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32606

1 Sample

Download data: XLS

(Submitter supplied) Chronic inflammation underpins many human diseases. The morbidity and mortality of chronic inflammation is often mediated through metabolic dysfunction. Inflammatory and metabolic processes vary through circadian time, suggesting an important temporal cross-talk between these systems. Here, we show that inflammatory arthritis results in rhythmic joint inflammation and drives major changes in muscle and liver energy metabolism and rhythmic gene expression.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

180 Samples

Download data: TXT

(Submitter supplied) The pathobiology of rheumatoid inflammatory diseases, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA), involves the interplay between innate and adaptive immune components and resident synoviocytes. Single-cell analyses of patient samples and relevant mouse models have characterized many cellular subsets in RA. However, the impact of interactions between cell types is not fully understood. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

5 Samples

Download data: MTX, TSV

(Submitter supplied) Aim: Synovial fibroblasts (SFs) undergo a rewiring of their DNA methylation landscape that is associated with their development of an aggressive pathogenic phenotype during Rheumatoid Arthritis (RA), both in humans and in CIA, a mouse model of this chronic inflammatory disease. The helminth-derived immunomodulator, ES-62 acts to prevent joint destruction in CIA by suppressing pathogenic SF responses. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL19057

3 Samples

Download data: TXT

(Submitter supplied) Our study reveals that many lncRNAs and mRNAs were differentially expressed between the brainstem of DBA/1 and C57BL/6 mouse

Organism:

Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platform:

GPL19286

8 Samples

Download data: TXT

(Submitter supplied) We observed resolution of inflammatory response in collagen-induced arthritis (CIA) mice. To identify molecular signatures defining resolution of the CIA, we applied microarray analysis for synovial tissues in the CIA mice in 6 (induction), 9 (peak) and 15 weeks (resolution) after immunization. To identify genes related to CIA resolution, we performed the following comparisons of gene expression profiles: peak versus induction phase and resolution versus peak phase. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

6 Samples

Download data: IDAT, TXT

(Submitter supplied) The prenatal and early postnatal period is highly sensitive to environmental exposures that may interfere with the developmental programming of the immune system leading to an altered disease risk in later life. To clarify the role of early influences in activation or exacerbation of autoimmune diseases like rheumatoid arthritis (RA) we investigated the effect of maternal exposure during the prenatal and weaning period of DBA/1 mice to the plasticizer benzyl butyl phthalate (BBP) on the development of RA in the offspring. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL20775

4 Samples

Download data: CEL

(Submitter supplied) 【Objectives】The FPR2 is a G-protein coupled receptor that potently possesses pro- and anti-inflammatory role. Although FPR2 is known to be expressed by T cells, its function in arthritic condition is unclear. We investigated the involvement of FPR2 on T cells in GPI-induced arthritis (GIA) and rheumatoid arthritis (RA). 【Methods】Fluctuated expression of FPR2 mRNA on CD4+T cells was analyzed in GIA. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

2 Samples

Download data: CEL, CHP

(Submitter supplied) To explore TNF-related genes in GPI-induced arthritis, we performed GeneChip analysis using arthritic splenocytes and control-immunized splenocytes. Among the arrayed TNFalpha-related genes, TIARP mRNA was highly expressed in arthritic splenocytes, with levels exceeding more than 20-times the control splenocytes

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

2 Samples

Download data: CEL