GEO DataSet Links for PMC (Select 2270833) - GEO DataSets

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Items: 2

Select item 2000143661.

Analysis of the retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection

(Submitter supplied) Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data suggest that neuroprotection after hypoxic preconditioning of the retina is the result of the differential expression of a multitude of genes which may act in concert to protect visual cells against a toxic insult. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3521
Platform:: GPL1261
24 Samples

Download data: CEL

Series

Accession:: GSE14366

ID:: 200014366

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 35212.

Retina response to hypoxia and subsequent reoxygenation: time course

Analysis of retinas subjected to hypoxia for 6 hours and subsequent reoxygenation for up to 16 hours. Hypoxic preconditioning protects photoreceptors from light damage in animal model. Results provide insight into the molecular basis of this protective effect.