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| Status |
Public on Jan 10, 2009 |
| Title |
Analysis of the retinal gene expression after hypoxic preconditioning identifies candidate genes for neuroprotection |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration.
Our data suggest that neuroprotection after hypoxic preconditioning of the retina is the result of the differential expression of a multitude of genes which may act in concert to protect visual cells against a toxic insult.
Keywords: hypoxic preconditioning, neuroprotection, transcription-profile, retina
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| Overall design |
In total 24 samples were analyzed on Affymetrix mouse 430.2 arrays, the samples represent different durations of regeneration (none = 0 h, 2 h, 4 h and 16 h) from hypoxic or normoxic treatments, that were tested in triplicates.
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| Contributor(s) |
Thiersch M, Raffelsberger W, Frigg R, Samardzija M, Wenzel A, Poch O, Grimm C |
| Citation(s) |
18261226 |
| |
| Submission date |
Jan 09, 2009 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Wolfgang Raffelsberger |
| E-mail(s) |
w.raffelsberger@unistra.fr
|
| Organization name |
IGBMC
|
| Department |
DBGS
|
| Lab |
LBGI
|
| Street address |
1 rue Laurent Fries
|
| City |
Illkirch/Strasbourg |
| ZIP/Postal code |
67404 |
| Country |
France |
| |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA111405 |
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