GEO DataSets

Analysis of rhabdomyosarcoma samples from A/J animals that are about 450 days old. A/J animals develop adult pleomorphic type rhabdomyosarcomas at a high frequency over 20 months of age. Results provide insight into the molecular pathogenesis of rhabdomyosarcoma.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 strain, 2 tissue sets

Platform:

GPL6481

Series:

GSE29775

12 Samples

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(Submitter supplied) Rhabdomyosarcomas (RSCs) are skeletal muscle neoplasms found in humans and domestic mammals. The A/J inbred strain developed a high frequency of RSC by 20 months of age while BALB/cJ and BALB/cByJ also develop RSC but less frequently. These neoplasms affected skeletal muscle surrounding either the axial or proximal appendicular skeleton and were characterized by pleomorphic cells with abundant eosinophilic cytoplasm, multiple nuclei, and cross striations that invaded locally. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5527

Platform:

GPL6481

12 Samples

Download data: TXT

(Submitter supplied) We identified muscles as cells of origin of rhabdomyosarcoma in dystrophic mice

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

16 Samples

Download data: TXT

(Submitter supplied) In vertebrate muscle, loss of Dysferlin results in the activation of compensatory muscle gene expression, even at pre-pathological stages. We hypothesized that if C. elegans fer-1 is also expressed in muscle, then fer-1 mutant worms might also exhibit compensatory muscle gene expression. To test this hypothesis, we used Affymetrix microarrays to profile gene expression from synchronized wild type and fer-1 mutant adults. more...

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array

Dataset:

GDS3579

Platform:

GPL200

12 Samples

Download data: CEL

Analysis of fer-1 loss of function C. elegans mutants. The fer-1 gene encodes a homolog for the human Dysferlin gene. Mutations in the human Dysferlin gene results in Limb Girdle Muscular Dystrophy 2B (LGMD2B). Results provide insight into the molecular pathogenesis of LGMD2B.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL200

Series:

GSE16753

12 Samples

Download data: CEL

(Submitter supplied) Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue sarcoma and resembles developing skeletal muscle. Specific genomic alterations including translocations, deletions and amplification events have been associated with the alveolar and embryonal subtypes of RMS. Characterizing these changes has led to increased understanding of the underlying molecular biology. However, further aberrations and their significance remain to be defined. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

13 Samples

Download data: CEL, CHP

(Submitter supplied) The p53 family comprises the tumor suppressor p53 and the structural homologs p63 and p73. How the three family members cooperate in tumor suppression remains unclear. Here, we report different but complementary functions of the individual members for regulating retinoblastoma protein (RB) function during myogenic differentiation. Whereas p53 transactivates the retinoblastoma gene, p63 and p73 induce the cyclin-dependent kinase inhibitor p57 to maintain RB in an active, hypophosphorylated state. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2420

Platform:

GPL1261

6 Samples

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Analysis of mock and deltaNp73alpha-expressing C2C12 myoblasts 6 and 24 hours after shifting the cells to a differentiation medium. DeltaNp73alpha, a p73alpha isoform, functions as a transdominant inhibitor of other p53 family members, interfering with multiple developmental programs.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 cell line, 3 time sets

Platform:

GPL1261

Series:

GSE5447

6 Samples

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