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| Status |
Public on Jun 04, 2009 |
| Title |
Effect of genomic imbalances on gene expression in rhabdomyosarcoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Rhabdomyosarcoma (RMS) is the most common paediatric soft-tissue
sarcoma and resembles developing skeletal muscle. Specific genomic
alterations including translocations, deletions and amplification events
have been associated with the alveolar and embryonal subtypes of RMS.
Characterizing these changes has led to increased understanding of the
underlying molecular biology. However, further aberrations and their
significance remain to be defined. Genomic copy number variations have
been shown to affect the level of transcription in several tumor types. In
this study, we have combined array comparative genomic hybridization analysis of 13 RMS cell lines, supported by confirmatory PCR analyses, with their corresponding expression profiles. This identified sets of genes that are altered in their level of expression by genomic imbalances. We also show that the effect on gene expression was proportional to the level of genomic gain or loss.
Keywords: Rhabdomyosarcoma cell lines
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| Overall design |
will be added later on
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| Contributor(s) |
Kool M |
| Citation(s) |
19235922 |
| Submission date |
Aug 22, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Linda Valentijn |
| Organization name |
Academic Medical Centre, University of Amsterdam
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| Department |
Department of Oncogenomics
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| Street address |
P.O. Box 22700
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| City |
Amsterdam |
| ZIP/Postal code |
1100DE |
| Country |
Netherlands |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (13)
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| GSM219592 |
SCMC-RMZ,Alveolar,rhabdomyosarcoma cell line |
| GSM219593 |
RMS,Alveolar,rhabdomyosarcoma cell line |
| GSM219726 |
RD,Embryonal,rhabdomyosarcoma cell line |
| GSM219743 |
RMS-YM,Embryonal,rhabdomyosarcoma cell line |
| GSM219745 |
RH18,Alveolar,rhabdomyosarcoma cell line |
| GSM219746 |
RUCH3,Embryonal,rhabdomyosarcoma cell line |
| GSM219747 |
CW9019,Alveolar,rhabdomyosarcoma cell line |
| GSM219748 |
RH41, Alveolar, rhabdomyosarcoma cell line |
| GSM219749 |
TE617T, rhabdomyosarcoma cell line |
| GSM219750 |
Hs729T,Pleomorphic,rhabdomyosarcoma cell line |
| GSM219755 |
RUCH-2,Embryonal,rhabdomyosarcoma cell line |
| GSM219756 |
RH4,Alveolar,rhabdomyosarcoma cell line |
| GSM219757 |
RH30,Alveolar,rhabdomyosarcoma cell line |
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| Relations |
| BioProject |
PRJNA102181 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE8840_RAW.tar |
110.3 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
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