GEO DataSets

Analysis of livers from males treated with the synthetic glucocoriticoid dexamethasone. Results compared to those from female livers (GDS5036). Results provide insight into the gender specific actions of glucocoriticoids in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL4134

Series:

GSE24256

6 Samples

Download data: TXT

(Submitter supplied) Glucocorticoids are widely used therapeutically to suppress inflammatory/immune responses and most of their effects are produced either by altering transcription of specific genes directly, or by altering the expression of transcription factors that subsequently alter the expression of downstream genes. Relevant data from previous studies indicate that the number of genes regulated by glucocorticoid receptor exceeds 4000 in cells and that 358 different genes are regulated in the liver of adrenalectomized males rats treated with a chronic infusion of methylprednisolone for up to 1 week . more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5035 GDS5036

Platform:

GPL4134

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Glucocorticoids are widely used therapeutically to suppress inflammatory/immune responses and most of their effects are produced either by altering transcription of specific genes directly, or by altering the expression of transcription factors that subsequently alter the expression of downstream genes. Relevant data from previous studies indicate that the number of genes regulated by glucocorticoid receptor exceeds 4000 in cells and that 358 different genes are regulated in the liver of adrenalectomized males rats treated with a chronic infusion of methylprednisolone for up to 1 week . more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

12 Samples

Download data: TIFF, TXT

(Submitter supplied) Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory hormone in all mammals and synthetic derivatives of these hormones are widely prescribed as anti-inflammatory agents irrespective of gender. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

12 Samples

Download data: TIFF, TXT

Analysis of livers from females treated with the synthetic glucocoriticoid dexamethasone. Results compared to those from male livers (GDS5035). Results provide insight into the gender specific actions of glucocoriticoids in the liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL4134

Series:

GSE24256

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL9250 GPL6887

33 Samples

Download data: BED, TXT, WIG

(Submitter supplied) Analysis of gender differential gene expression levels in mouse liver.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

16 Samples

Download data: TXT

(Submitter supplied) For the genome-wide analysis using ChIP-Seq on mouse liver cells, a full accounting of all RXRα binding sites and of RXRa related gene regulations is expected to address the main knowledge gap around RXRα.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9250

17 Samples

Download data: BED, TXT, WIG

(Submitter supplied) The purpose of this experiment was to determine the expression traits in animals of inbred strain C57BL/6J, treated with gonadal hormones. (N=40, 20 males and 20 females).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

40 Samples

Download data

(Submitter supplied) The purpose of this experiment was to determine the expression traits in Liver tissue from the Four Core Genotype treated group. Keywords: Sry transgene Four Core Genotype Mouse liver Tissue

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2510

20 Samples

Download data

(Submitter supplied) Glucocorticoids play central roles in the regulation of energy metabolism by shifting it toward catabolism, while AMPK is the master regulator of energy homeostasis, sensing energy depletion and stimulating pathways of increasing fuel uptake and saving on peripheral supplies. We showed here that AMPK regulates glucocorticoid actions on carbohydrate metabolism by targeting the glucocorticoid receptor (GR) and modifying transcription of glucocorticoid-responsive genes in a tissue- and promoter-specific fashion. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

8 Samples

Download data: CEL

(Submitter supplied) A series of dual-channel gene expression profiles obtained using MWG Rat 5K microarrays (~5535 unique rat genes) and MWG Rat Liver microarrays (~1353 unique rat genes with 999 of these genes also represented on the Rat 5K microarray) was used to examine the sex-dependent and GH-dependent differences in gene expression in adult rat liver. This series is comprised of 8 randomly chosen pairings of independent male and female rat liver cDNA samples and 8 randomly chosen pairings of independent male and continuous GH-treated male rat liver cDNA samples, totaling 16 samples. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS862 GDS863

Platforms:

GPL529 GPL500

16 Samples

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Investigation of regulatory role of growth hormone (GH) in sexually dimorphic gene expression. Liver tissue examined from adult male and female rats untreated or treated with GH by 7 day continuous infusion.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 other sets

Platform:

GPL529

Series:

GSE1146

8 Samples

Download data

Investigation of regulatory role of growth hormone (GH) in sexually dimorphic gene expression. Liver tissue from adult male and female rats untreated or treated with GH by 7 day continuous infusion examined.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 other sets

Platform:

GPL500

Series:

GSE1146

8 Samples

Download data

(Submitter supplied) Glucocorticoids are a class of steroid hormones that bind to and activate the Glucocorticoid Receptor, which then positively or negatively regulates transcription of many genes that govern multiple important physiological pathways such as inflammation and metabolism of glucose, fat and bone. Previous studies focusing on single coregulators demonstrated that each coregulator is required for regulation of only a subset of all the genes regulated by a steroid hormone. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10558

40 Samples

Download data: TXT

(Submitter supplied) Glucocorticoids induce rapid apoptosis of rat primary thymocytes through mechanisms requiring altered gene expression. The determination of genes regulating glucocorticoid-induced apoptosis of lymphocytes has received considerable attention. However, the role of specific non-coding microRNAs in the regulation of glucocorticoid-induced apoptosis of lymphocytes is poorly defined. Using deep sequencing analysis, we have identified microRNAs differentially expressed during glucocorticoid-induced apoptosis of rat primary thymocytes. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

8 Samples

Download data: TXT

(Submitter supplied) Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought to determine the sexually dimorphic actions of glucocorticoid signaling in cardiac function and gene expression. To accomplish this goal, we conducted studies on mice lacking glucocorticoid receptors (GR) in cardiomyocytes (cardioGRKO mouse model). Methods and Results Deletion of cardiomyocyte GR leads to an increase in mortality because of the development of spontaneous cardiac pathology in both male and female mice; however, females are more resistant to GR signaling inactivation in the heart. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

12 Samples

Download data: TXT

(Submitter supplied) Effect of continuous GH treatment on old rat liver. Male rats, 2-year-old, were treated with vehicle or human GH (0.34 microgram/gram body weight) for 3 weeks. Keywords: response of old rat liver to growth hormone

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

4 Samples

Download data

(Submitter supplied) Gene expression differences between mal and female rat livers (female/male). Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

4 Samples

Download data

(Submitter supplied) male young rats treated with bGH (minipumps for a week before RNA was prepared from livers Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1921

4 Samples

Download data