Similar studies for GEO DataSets (Select 4863) - GEO DataSets

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Items: 4

Select item 48631.

HIV envelope protein gp120 effect on activated B cells from healthy donors: time course

Temporal analysis of B cells isolated from healthy donors in response to activation in the presence of HIV-1 envelope protein gp120 with high (gp120++) or low (gp120-) affinity for integrin α4β7. Results provide insight into mechanisms by which α4β7-gp120 interaction negatively affects B cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 6 individual, 4 protocol, 4 time sets

Platform:: GPL6244
Series:: GSE49019
42 Samples

Download data: CEL

DataSet

Accession:: GDS4863

ID:: 4863

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000490192.

HIV-1 gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression via an α4β7-dependent mechanism

(Submitter supplied) The anti-HIV humoral immune response following acute infection is delayed and ineffective. HIV envelope protein gp120 binds to and signals through α4β7 on T cells. We show that gp120 also binds and signals through α4β7 on B cells, resulting in an abortive proliferative response. In primary B cells, gp120 signaling through α4β7 resulted in increased expression of TGF-β1 and the B cell inhibitory receptor FcRL4. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4863
Platform:: GPL6244
42 Samples

Download data: CEL

Series

Accession:: GSE49019

ID:: 200049019

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000873843.

Characterization of human Fcrl4-positive B cells

(Submitter supplied) FCRL4 is an immunoregulatory receptor that belongs to the Fc receptor-like (FCRL) family. In healthy individuals, this protein is specifically expressed by memory B cells (MBCs) and is preferentially localized in subephitelial regions of lymphoid tissues. An expansion of FCRL4+ B cells has been shown in blood or other tissues in various infectious or autoimmune pathologies. In the present work, we generated and characterized in vitro FCRL4+ B cells from purified MBCs using T-dependent and/or T-independent stimulation. more...