GEO DataSets

Analysis of primary cortical neurons treated with nitric oxide (NO) generator DETA-NONOate for up to 24 hrs. High doses of NO, often observed in neurodegenerative disease pathogenesis, cause neuronal death. Results provide insight into molecular events contributing to NO-induced neuronal injury.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 4 time sets

Platform:

GPL1261

Series:

GSE22087

14 Samples

Download data: CEL

(Submitter supplied) Nitric oxide (NO) is implicated in the pathogenesis of various neuropathologies characterised by oxidative stress. NO has been reported to be involved in the exacerbation of oxidative stress by various mechanisms, including protein modification, genotoxic damage and elevated production of reactive oxygen species resulting in deregulation and disruption of cellular homeostasis. Although multiple roles for NO has been reported in neuronal death signaling, existent data fail to provide a holistic description of how nitrergic pathobiology elicits neuronal injury. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4408

Platform:

GPL1261

14 Samples

Download data: CEL

(Submitter supplied) Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagonist. The current study focused on gaining an insight into the molecular mechanisms of H2S–mediated neuronal death pertaining to NMDA receptors activation through global gene expression comparisons.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8540

24 Samples

Download data: TXT

(Submitter supplied) Our aim was to identify genes that were differentially expressed in microglia stimulated with Lipopolysaccharide, Luteolin, or both. Affymetrix microarrays were used to analyze RNA samples

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3613

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of lipopolysaccharide-activated microglial BV-2 cells treated with luteolin, a plant derived flavonoid. Luteolin possesses the ability to scavenge oxygen and nitrogen species, and exhibits anti-inflammatory activities. Results provide insight into the immuno-modulatory effects of luteolin.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL1261

Series:

GSE18740

12 Samples

Download data: CEL

(Submitter supplied) Nitric oxide being a versatile molecule inside biological systems, from being both a cell signaling molecule to a potent stress agent, has significant effect in the transcriptional response in fission yeast. We have used fission yeast microarrays to identify cellular targets of Nitric Oxide (NO) and to further understand the cellular mechanism of NO action. We report the change in the global gene expression profile response to NO in S. more...

Organism:

Schizosaccharomyces pombe; Saccharomyces cerevisiae

Type:

Expression profiling by array

Dataset:

GDS5814

Platform:

GPL2529

8 Samples

Download data: CEL

Analysis of activator protein 1 (Pap1)-deficient 972h- strain exposed to the nitric oxide donor compound detaNONOate. Pap1 is required to combat nitrosative stress. Results provide insight into molecular mechanisms underlying the nitrosative stress response.

Organism:

Schizosaccharomyces pombe; Saccharomyces cerevisiae

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 stress sets

Platform:

GPL2529

Series:

GSE50899

8 Samples

Download data: CEL

(Submitter supplied) Traumatic brain injury is one of the common cause of adult permanent disability. As its physio-pathological mechanism has yet to be elucidated, by adopting microarray technique we hope to decipher the novel signaling cascades involved, and if different severity of injury would induce any form of neuronal regeneration.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL8031

34 Samples

Download data: TXT