Nitric oxide generator DETA-NONOate effect on in vitro neuronal injury model: time course
Summary:
Analysis of primary cortical neurons treated with nitric oxide (NO) generator DETA-NONOate for up to 24 hrs. High doses of NO, often observed in neurodegenerative disease pathogenesis, cause neuronal death. Results provide insight into molecular events contributing to NO-induced neuronal injury.
Peng ZF, Chen MJ, Manikandan J, Melendez AJ et al. Multifaceted role of nitric oxide in an in vitro mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades. J Cell Mol Med 2012 Jan;16(1):41-58. PMID: 21352476
