GEO DataSets

Analysis of PBMCs from healthy males after 3 weeks of virgin olive oil (VOO) consumption at doses common in the Mediterranean diet. The Mediterranean diet protects against cardiovascular diseases. Results provide insight into the molecular mechanisms underlying the beneficial action of VOO.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 protocol, 3 time sets

Platform:

GPL6511

Series:

GSE10590

9 Samples

Download data: TXT

(Submitter supplied) Olive oil is protective against risk factors for cardiovascular and cancer diseases. A nutrigenomic approach was performed to assess whether olive oil, the main fat of the Mediterranean diet modifies the gene expression in human peripheral blood mononuclear cells. Six healthy male volunteers ingested, at fasting state, 50 ml of olive oil, and continued with the same olive oil as a source of raw fat (25ml/day) during 3 weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3691

Platform:

GPL6511

9 Samples

Download data: TXT

(Submitter supplied) see manufacturer's web site https://products.appliedbiosystems.com/ab/en/US/adirect/ab;jsessionid=HyNBrYvlwy6ncF1Kn3KVLSLwlbXWyxZLRyZJthLvtFdht7vG2L2T!161467451?cmd=catProductDetail&productID=4359030&catID=602388&backButton=true

Organism:

Homo sapiens

1 DataSet

1 Series

9 Samples

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(Submitter supplied) Despite the benefits associated with healthy diets, data on the mechanisms by which these benefits are promoted are scarce. Our aim was to explore the global transcriptomic response of biological pathways related to cardiovascular disease associated with traditional Mediterranean diet (TMD) intervention. The PREDIMED study is a large on-going, parallel, multicentre, randomised, controlled trial aimed at assessing the TMD effect on primary cardiovascular prevention. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL571

65 Samples

Download data: CEL

(Submitter supplied) Some studies have shown that acute intake of high-phenol virgin olive oil reduces pro-inflammatory, pro-oxidant and pro-thrombotic states, but nowadays still remains unclear if those effects attributed to its phenolic fraction could be exerted at transcriptional level in vivo. Two virgin olive oil-based breakfasts with high (398 ppm) and low (70 ppm) content of phenolic compounds were administered to twenty patients (9 men and 11 women) with metabolic syndrome following a double-blinded random crossover design. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

80 Samples

Download data: TXT

(Submitter supplied) Two isocaloric, isonitrogenous diets containing 10% (w/w) olive oil or unsaponifiable-enriched olive oil have been provided to male apo E knockout mice for 11 weeks. Then RNA was isolated and hepatic gene expression analyzed. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

2 Samples

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(Submitter supplied) The acute response four hours after a fat load of extra virgin olive oil was investigated using DNA microarrays. Hepatic gene expression was analysed in Wistar Rats.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

2 Samples

Download data: CEL

(Submitter supplied) We used Affymetrix microarrays to investigate gene expression changes in PBMNCs isolated from female and male pigs to determine significant modulatory effects that may have been induced by the intake of resveratrol during 9 months in high-fat fed animals .

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

22 Samples

Download data: CEL