GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE28358 Query DataSets for GSE28358
Status Public on Jun 30, 2013
Title Gene expression changes in human peripheral blood mononuclear cells after 3 diet interventions, TMD enriched with olive oil, TMD enriched with nuts and Low fat diet.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Despite the benefits associated with healthy diets, data on the mechanisms by which these benefits are promoted are scarce. Our aim was to explore the global transcriptomic response of biological pathways related to cardiovascular disease associated with traditional Mediterranean diet (TMD) intervention. The PREDIMED study is a large on-going, parallel, multicentre, randomised, controlled trial aimed at assessing the TMD effect on primary cardiovascular prevention. High cardiovascular risk participants were recruited and assigned to one of the following interventions: 1) TMD plus virgin olive oil (VOO); 2) TMD plus mixed nuts; or 3) low-fat diet (control group). In a sub sample of 30 volunteers of the PREDIMED- Barcelona Sur Centre, gene expression changes in peripheral mononuclear cells, after 3 months of intervention, were assessed by microarray analysis.
Overall design A parallel study comparing three diet interventions: We analyzed 65 arrays which belonged to 34 patients, 31 microarrays at baseline (11 baseline group 1; 11 baseline group 2; 9 baseline group 3) and 34 microarrays after the 3 month intervention (11 for group 1; 11 for group 2; and 12 for group 3). The three interventions were: Group 1: 3-month Traditional Mediterranean Diet enriched with virgin olive oil; Group 2: 3-month Traditional Mediterranean Diet enriched with nuts; and Group 3: 3-month Low Fat Diet.
Contributor(s) Castaner O, Fito M, Covas M, Corella D, Portoles O
Citation(s) 23902780
Submission date Apr 04, 2011
Last update date Dec 06, 2018
Contact name Olga Castaner
Organization name IMIM
Department Nutrition and cardiovascular risk department
Lab Nutrtion and cardiovascular risk biomolecular laboratory
Street address Aiguader 88
City Barcelona
ZIP/Postal code 08003
Country Spain
Platforms (1)
GPL571 [HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array
Samples (65)
GSM701076 OP1
GSM701078 OP2
GSM701080 OP3
BioProject PRJNA139417

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE28358_RAW.tar 94.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap