Similar studies for GEO DataSets (Select 3345) - GEO DataSets

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Items: 18

Select item 33451.

Various mental disorders: postmortem brains

Analysis of postmortem prefrontal cortices from subjects with bipolar disorder, depression, and schizophrenia. Results provide insight into the molecular pathophysiology of these mental disorders.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 4 disease state sets

Platform:: GPL8300
Series:: GSE12654
50 Samples

Download data: CEL

DataSet

Accession:: GDS3345

ID:: 3345

Select item 2000126542.

Gene expression from human prefrontal cortex (BA10)

(Submitter supplied) We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by the Stanley Foundation Brain Collection. By comparing the gene expression profiles of similar but distinctive mental disorders, we explored the uniqueness of bipolar disorder and its similarity to other mental disorders at the molecular level. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3345
Platform:: GPL8300
50 Samples

Download data: CEL

Series

Accession:: GSE12654

ID:: 200012654

Select item 2000126493.

Gene expression from human prefrontal cortex (BA46)

(Submitter supplied) Accumulating evidence suggests that mitochondrial dysfunction underlies the pathophysiology of bipolar disorder (BD) and schizophrenia (SZ). We performed large-scale DNA microarray analysis of postmortem brains of patients with BD or SZ, and examined expression patterns of mitochondria-related genes. We found a global down-regulation of mitochondrial genes, such as those encoding respiratory chain components, in BD and SZ samples, even after the effect of sample pH was controlled. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
102 Samples

Download data: CEL

Series

Accession:: GSE12649

ID:: 200012649

Select item 2000539874.

Microarray profiling of PFC, HPC and STR from subjects with schizophrenia, bipolar, MDD or control

(Submitter supplied) Schizophrenia is a complex psychiatric disorder encompassing a range of symptoms and etiology dependent upon the interaction of genetic and environmental factors. Several risk genes, such as DISC1, have been associated with schizophrenia as well as bipolar disorder (BPD) and major depressive disorder (MDD), consistent with the hypothesis that a shared genetic architecture could contribute to divergent clinical syndromes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
205 Samples

Download data: CEL

Series

Accession:: GSE53987

ID:: 200053987

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000806555.

RNA-sequencing of human post-mortem brain tissues

(Submitter supplied) RNA-seq profiling was conducted on clinically-annotated human post-mortem brain tissues

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
281 Samples

Download data: TXT

Series

Accession:: GSE80655

ID:: 200080655

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000070366.

Expression profiling in monozygotic twins discordant for bipolar disorder

(Submitter supplied) To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by ≥ 1.3-fold in 3 BD1 cases compared to their co-twins, and which were statistically (p ≤ 0.05) differentially expressed between the groups of BD1 cases and controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2779
Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE7036

ID:: 200007036

Select item 27797.

Lymphoblastoid cell lines from monozygotic twin pairs discordant for bipolar disorder

Analysis of lymphoblastoid cell lines derived from 3 monozygotic twin pairs discordant for bipolar disorder. Results provide insight into the molecular pathogenesis of bipolar disorder.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state, 3 other sets

Platform:: GPL570
Series:: GSE7036
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS2779

ID:: 2779

Select item 2000053928.

Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
82 Samples

Download data: CEL

Series

Accession:: GSE5392

ID:: 200005392

Select item 2000053899.

Adult postmortem brain tissue (orbitofrontal cortex) from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2191
Platform:: GPL96
21 Samples

Download data: CEL

Series

Accession:: GSE5389

ID:: 200005389

Select item 20000538810.

Adult postmortem brain tissue (dorsolateral prefrontal cortex) from subjects with bipolar disorder and healthy controls

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2190
Platform:: GPL96
61 Samples

Download data: CEL

Series

Accession:: GSE5388

ID:: 200005388

Select item 219111.

Bipolar disorder: orbitofrontal cortex

Analysis of postmortem orbitofrontal cortex from 10 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE5389
21 Samples

Download data: CEL

DataSet

Accession:: GDS2191

ID:: 2191

Select item 219012.

Bipolar disorder: dorsolateral prefrontal cortex

Analysis of postmortem dorsolateral prefrontal cortex from 30 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL96
Series:: GSE5388
61 Samples

Download data: CEL

DataSet

Accession:: GDS2190

ID:: 2190

Select item 20004254613.

Whole transcriptome analysis of postmortem human hippocampus dentate gyrus granlule cells

(Submitter supplied) We investigated the transcriptome of dentate gyrus (DG) granule cells in postmortem hippocampus from 79 subjects with mental illness (schizophrenia, bipolar disorder, major depression) or non-psychiatric controls.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13393
79 Samples

Download data: TXT

Series

Accession:: GSE42546

ID:: 200042546

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006233314.

Transcriptomic profiles of skin fibroblasts from patients affected by schizophrenia and controls

(Submitter supplied) Whole-genome expression studies in peripheral tissues of patients affected by schizophrenia (SCZ) can provide new insights into the molecular basis of the disorder and innovative biomarkers that may be of great usefulness in the clinical practice. Recent evidence suggests that skin fibroblasts could represent a non-neural peripheral model useful to investigate molecular alterations in psychiatric disorders. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL11532
40 Samples

Download data: CEL

Series

Accession:: GSE62333

ID:: 200062333

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008761015.

Gene expression of L3 and L5 pyramidal neurons in the DLPFC comparing schizophrenia from bipolar major depressive disorders and unaffected subjects.

(Submitter supplied) Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder (BP) and least in major depressive disorder (MDD). Given that working memory depends, in part, on neural circuitry that includes pyramidal neurons in layer 3 (L3) and layer 5 (L5) of the dorsolateral prefrontal cortex (DLPFC), we sought to determine if transcriptome alterations in these neurons were shared or distinctive for each diagnosis.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13667
286 Samples

Download data: CEL

Series

Accession:: GSE87610

ID:: 200087610

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006219116.

Gene expression profiles of patients with schizophrenia, bipolar disorder and healthy controls

(Submitter supplied) Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric conditions, with a lifetime prevalence of about 1%. Both disorders have a neurodevelopment component, with onset of symptoms occurring most frequently during late adolescence or early adulthood. Genetic findings indicate the existence of an overlap in genetic susceptibility across the disorders. These gene expression profiles were used to identify the molecular mechanisms that differentiate SZ and BP from healthy controls but also that distinguish both from healthy individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
88 Samples

Download data: TXT

Series

Accession:: GSE62191

ID:: 200062191

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003887317.

Correlation between DNA methylation and gene expression in the brains of patients with bipolar disorder and schizophrenia

(Submitter supplied) Aberrant DNA methylation and gene expression have been reported in postmortem brain tissues of psychotic patients, but until now there has been no systematic evaluation of synergistic changes in methylation and expression on a genome-wide scale in brain tissue. In this study, genome-wide methylation and expression analyses were performed on cerebellum samples from 39 patients with schizophrenia, 36 patients with bipolar disorder, and 43 unaffected controls, to screen for a correlation between gene expression and CpG methylation. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
168 Samples

Download data: TXT

Series

Accession:: GSE38873

ID:: 200038873

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021006418.

Gene expression alterations in the postmortem hippocampus from older patients with bipolar disorder – a hypothesis generating study

(Submitter supplied) Gene expression of samples from the postmortem hippocampus of older bipolar disorder subjects and controls. Gene expression data was generated using the SurePrint G3 Human Gene Expression v3 microarray. Rank feature selection was performed to identify a subset of features that can optimally differentiate BD and controls.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20844
22 Samples

Download data: TXT

Series

Accession:: GSE210064

ID:: 200210064

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