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Series GSE5388 Query DataSets for GSE5388
Status Public on Jul 27, 2006
Title Adult postmortem brain tissue (dorsolateral prefrontal cortex) from subjects with bipolar disorder and healthy controls
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. Differences between disease and control groups were identified using a rigorous statistical analysis with correction for confounding variables and multiple testing.
Keywords: disease state analysis
Overall design RNA extracted from human postmortem brain tissue from adult subjects with bipolar disorder and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.
Contributor(s) Bahn S, Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ
Citation(s) 16894394
Submission date Jul 25, 2006
Last update date Aug 10, 2018
Contact name Sabine Bahn
Organization name University of Cambridge
Lab Cambridge Centre for Neuropsychiatric Research
Street address Tennis Court Road
City Cambridge
ZIP/Postal code CB2 1QT
Country United Kingdom
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (61)
GSM123182 brain_DLPFC_bipolar B_mr279
GSM123183 brain_DLPFC_bipolar B_mr281
GSM123184 brain_DLPFC_bipolar B_mr282
This SubSeries is part of SuperSeries:
GSE5392 Expression profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
BioProject PRJNA104325

Download family Format
SOFT formatted family file(s) SOFTHelp
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Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE5388_RAW.tar 206.8 Mb (http)(custom) TAR (of CEL)

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