GEO DataSets

Analysis of nu61 radioresistant tumors 5 and 24 hours following exposure to ionizing radiation. Nu61 tumors derived from the radiosensitive squamous cell carcinoma cell line SCC61. Results provide insight into the molecular basis of acquired tumor radioresistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 development stage, 3 time sets

Platform:

GPL96

Series:

GSE9713

18 Samples

Download data: CEL, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

38 Samples

Download data: CEL, EXP

(Submitter supplied) Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors xenografts were profiled in two independent experiments using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3126

Platform:

GPL96

8 Samples

Download data: CEL, EXP

(Submitter supplied) Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors were profiled using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway Keywords: Pair-wise comparison of radiosensitive vs radioresistant tumors; time course of irradation response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3125

Platform:

GPL96

18 Samples

Download data: CEL, EXP

(Submitter supplied) Nu61, a radiation-resistant human tumor xenograft, was selected from a parental radiosensitive tumor SCC-61 by eight serial cycles of passage in athymic nude mice and in vivo irradiation. Obtained tumors were profiled using Affymetrix U133A arrays. Most abundant gene pattern associated with radioresistant phenotype was presented by IFN-inducible, Stat1-dependent pathway Keywords: Pair-wise comparison of radiosensitive vs radioresistant tumors

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3124

Platform:

GPL96

12 Samples

Download data: CEL, EXP

Analysis of nu61 radioresistant tumors following treatment with a mixture of interferons (IFNs) alpha, beta, and gamma. Nu61 tumors derived from the radiosensitive squamous cell carcinoma cell line SCC61. Results provide insight into the role of the IFN signaling pathway in tumor radioresistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 development stage sets

Platform:

GPL96

Series:

GSE9714

8 Samples

Download data: CEL, EXP

Analysis of nu61 radioresistant tumors following exposure to ionizing radiation. Nu61 tumors derived from the radiosensitive squamous cell carcinoma cell line SCC61. Results provide insight into the molecular basis of acquired tumor radioresistance.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 2 development stage sets

Platform:

GPL96

Series:

GSE9712

12 Samples

Download data: CEL, EXP

(Submitter supplied) Background: Signal Transducer and Activator of Transcription 1 (STAT1) has traditionally been regarded as a transmitter of interferon signaling and a pro-apoptotic tumor suppressor. Recent data have identified new functions of STAT1 associated with tumorigenesis and resistance to genotoxic stress, including ionizing radiation (IR) and chemotherapy. To investigate the mechanisms contributing to the tumorigenic functions of STAT1, we performed a combined transcriptomic-proteomic expressional analysis and found that STAT1 is associated with regulation of energy metabolism. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

8 Samples

Download data: CEL