Similar studies for GEO DataSets (Select 2763) - GEO DataSets

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Items: 17

Select item 27631.

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy: dendritic cells

Analysis of in vitro differentiated dendritic cells (DCs) from patients with PLOSL, an early onset dementia with bone cysts caused by mutations in DAP12 and TREM2 genes which encode important signaling molecules in DCs. Results provide further insight into mechanisms underlying PLOSL pathogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state, 3 genotype/variation sets

Platform:: GPL96
Series:: GSE3624
8 Samples

Download data

DataSet

Accession:: GDS2763

ID:: 2763

Select item 2000036242.

Transcript profiles of DCs of PLOSL patients show abnormalities in pathways of actin bundling and immune response

(Submitter supplied) This study was aimed to identify pathways associated with loss-of-function of the DAP12/TREM2 receptor complex and thus gain insight into pathogenesis of PLOSL (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy). Transcript profiles of PLOSL patients' DCs showed differential expression of genes involved in actin bundling and immune response, but also for the stability of myelin and bone remodeling. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2763
Platform:: GPL96
8 Samples

Download data

Series

Accession:: GSE3624

ID:: 200003624

Select item 2000222823.

Mature dendritic cells under hypoxic condition

(Submitter supplied) Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs and maturation into mature DCs. Mature DCs were differentiated in vitro from human monocytes under normoxic or hypoxic conditions and the gene expression profile was determined. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3858
Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE22282

ID:: 200022282

Select item 38584.

Hypoxia effect on monocyte-derived, mature dendritic cells

Analysis of mature dendritic cells (mDC) generated from monocytes under chronic hypoxia (1%O2). Hypoxia is a common feature at pathologic sites that creates a unique microenvironment affecting cell phenotype and behavior. Results provide insight into the impact of chronic hypoxia on mDC development.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL570
Series:: GSE22282
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3858

ID:: 3858

Select item 2000335035.

Gene expression profile of DAP12 knockdown THP-1 cells following exposure to phorbol 12-myristate 13-acetate

(Submitter supplied) Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), is a rare autosomal recessive disorder characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by a loss-of-function mutation of DAP12 or TREM2. TREM2 and DAP12 constitute a receptor/adaptor complex expressed on osteoclasts, dendritic cells, macrophages, monocytes, and microglia. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4137
Platform:: GPL6244
4 Samples

Download data: CEL, CHP

Series

Accession:: GSE33503

ID:: 200033503

Select item 2000335006.

Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
3 Samples

Download data: CEL, CHP

Series

Accession:: GSE33500

ID:: 200033500

Select item 41377.

Nasu-Hakola disease model: DAP12 knockdown THP-1 clones

Analysis of DAP12-deficient acute monocytic leukemia THP-1 cells that serve as a model of NHD, following treatment with 12-myristate 13-acetate (PMA). PMA is a known inducer of morphological differentiation of THP-1 cells. Results provide insight into molecular mechanisms underlying NHD pathology.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL6244
Series:: GSE33503
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4137

ID:: 4137

Select item 2000669268.

Expression data from WT and TREM2 deficient microglia in response to cuprizone mediated demyelination

(Submitter supplied) We examined the role of TREM2 on microglia responses to demyelination

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
10 Samples

Download data: CEL

Series

Accession:: GSE66926

ID:: 200066926

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000254969.

Transcriptome analysis of the Nasu-Hakola disease brain

(Submitter supplied) Nasu-Hakola disease (NHD), also designated polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL; OMIM 221770), is a rare autosomal recessive disorder, characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by genetic mutations of DAP12 and TREM2, which constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells, macrophages, and microglia. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE25496

ID:: 200025496

Select item 20001376210.

Comparative gene expression profile of 1,25-dihydroxyvitamin D3-treated human monocyte-derived dendritic cells

(Submitter supplied) We have carried out global gene expression analysis to clarify the interrelationship between 1,25-dihydroxyvitamin D3 and differentiation-driven gene expression patterns in developing human monocyte-derived dendritic cells. Monocytes were treated with 10 nM 1,25-dihydroxyvitamin D3 or vehicle 14 hours after plating for 12 hours or 5 days. Monocytes, differentiating dendritic cells (+/-1,25-dihydroxyvitamin D3 for 12 hours) and immature dendritic cells (+/-1,25-dihydroxyvitamin D3 for 5 days) were harvested. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
15 Samples

Download data: CEL

Series

Accession:: GSE13762

ID:: 200013762

Select item 20007756911.

RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment

(Submitter supplied) High throughput massively parallel sequencing on mRNA libraries generated from cortices of bexarotene or vehicle treated APP/PS1

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE77569

ID:: 200077569

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000686312.

Immature dendritic cells under hypoxic condition

(Submitter supplied) Dendritic cells (DCs) are professional antigen-presenting cells whose activity is intrinsically linked to the microenvironment. Hypoxia is a condition of low oxygen tension occurring in inflammatory tissues that creates a special microenvironment conditioning cell physiology. We studied the effects of hypoxia on the differentiation of human monocytes into DCs. Immature DCs were differentiated in vitro from human monocytes under normoxic (iDCs) or hypoxic (Hi-DCs) conditions and the gene expression profile was determined. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2750
Platform:: GPL570
6 Samples

Download data: CEL

Series

Accession:: GSE6863

ID:: 200006863

Select item 275013.

Immature dendritic cell response to hypoxia in vitro

Analysis of immature dendritic cells (DCs) differentiated from monocytes under hypoxia for 4 days. DCs are antigen presenting cells whose development is influenced by the microenvironment. Hypoxia is an important constituent of the microenvironment of inflamed tissues.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 stress sets

Platform:: GPL570
Series:: GSE6863
6 Samples

Download data: CEL

DataSet

Accession:: GDS2750

ID:: 2750

Select item 20015087714.

Coupled single cell RNA-seq and intracellular protein activity reveals immune-suppressive role of Trem2 in cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057
72 Samples

Download data: TAR, TXT

Series

Accession:: GSE150877

ID:: 200150877

PubMed Similar studies

Select item 20015087615.

Coupled single cell RNA-seq and intracellular protein activity reveals immune-suppressive role of Trem2 in cancer II

(Submitter supplied) Cell function and activity is regulated through integration of signaling, epigenetic, transcriptional and metabolic pathways. Here we introduce INs-seq, an integrated technology for massively parallel recording of single-cell RNA-sequencing (scRNA-seq) and intracellular protein activity. We demonstrate the broad utility of INs-seq for reveling new immune subsets by profiling different intracellular signatures of immune signaling, transcription-factor combinations and metabolic activity. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057
20 Samples

Download data: TAR

Series

Accession:: GSE150876

ID:: 200150876

PubMed Similar studies SRA Run Selector

Select item 20015087216.

Coupled single cell RNA-seq and intracellular protein activity reveals immune-suppressive role of Trem2 in cancer I

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
52 Samples

Download data: TXT

Series

Accession:: GSE150872

ID:: 200150872

PubMed Similar studies SRA Run Selector

Select item 20003119517.

Study of the consistency, comparability and identity of different Dendritic cells productions for clinical use

(Submitter supplied) Gene expression profiling of monocyte-derived Dendritic cells manufactured several times from one healthy donor and one single time from 8 different healthy donors to test the sources of variability Sources tested: Assay-related variability (8 samples), Manufacture-related variability (5 samples), Intra-donor-related variability (5 samples), inter-donor-related variability (9 samples)