GEO DataSets

Analysis of postmortem orbitofrontal cortex from 10 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL96

Series:

GSE5389

21 Samples

Download data: CEL

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex and orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

82 Samples

Download data: CEL

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (orbitofrontal cortex) from patients with bipolar disorder and matched healthy controls. Orbitofrontal cortex tissue from a cohort of 30 subjects was investigated and the final analysis included 10 bipolar and 11 control subjects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2191

Platform:

GPL96

21 Samples

Download data: CEL

(Submitter supplied) Bipolar affective disorder is a severe psychiatric disorder with a strong genetic component but unknown pathophysiology. We used microarray technology (Affymetrix HG-U133A GeneChips) to determine the expression of approximately 22 000 mRNA transcripts in post-mortem brain tissue (dorsolateral prefrontal cortex) from patients with bipolar disorder and matched healthy controls. A cohort of 70 subjects was investigated and the final analysis included 30 bipolar and 31 control subjects. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2190

Platform:

GPL96

61 Samples

Download data: CEL

Analysis of postmortem dorsolateral prefrontal cortex from 30 adults with bipolar disorder. Results provide insight into the pathophysiology of the disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL96

Series:

GSE5388

61 Samples

Download data: CEL

(Submitter supplied) Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. Schizophrenia is a severe psychiatric disorder with a world-wide prevalence of 1%. The pathophysiology of the illness is not understood, but is thought to have a strong genetic component with some environmental influences on aetiology. To gain further insight into disease mechanism, we used microarray technology to determine the expression of over 30 000 mRNA transcripts in post-mortem tissue from a brain region associated with the pathophysiology of the disease (Brodmann area 10: anterior prefrontal cortex) in 28 schizophrenic and 23 control patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4523

Platform:

GPL570

51 Samples

Download data: CEL

Analysis of post-mortem tissue from the anterior prefrontal cortex (Brodmann Area 10, BA10) of schizophrenic patients. The BA10 region mediates the negative pathophysiology of schizophrenia. Results provide insight into molecular mechanisms underlying the negative symptoms of schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 33 age, 2 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE17612

51 Samples

Download data: CEL

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2941

Platform:

GPL96

15 Samples

Download data: CEL

Analysis of postmortem brains of individuals with Down syndrome. Results provide insight into the pathogenesis of Down syndrome.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL96

Series:

GSE5390

15 Samples

Download data: CEL

(Submitter supplied) Transcriptional analysis of the superior temporal cortex (BA22) in schizophrenia: Pathway insight into disease pathology and drug development Schizophrenia is a highly debilitating psychiatric disorder which is known to have heritable genetic and environmental components. To gain some insight into the mechanisms underpinning both positive and negative symptoms of the disease, we determined the genome wide expression of mRNA transcripts in post-mortem tissue from the superior temporal cortex (Brodmann Area 22, BA22) in schizophrenic and control patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4522

Platform:

GPL570

42 Samples

Download data: CEL

Analysis of post-mortem tissue from the superior temporal cortex (Brodmann Area 22, BA22) of schizophrenic patients. The BA22 region mediates the positive pathophysiology of schizophrenia. Results provide insight into molecular mechanisms underlying the positive symptoms of schizophrenia.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 30 age, 2 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE21935

42 Samples

Download data: CEL

(Submitter supplied) Schizophrenia is associated with alterations in working memory that reflect dysfunction of dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of excitatory pyramidal cells in DLPFC layer 3, and to a lesser extent in layer 5. Although many studies have profiled gene expression in DLPFC gray matter in schizophrenia, little is known about cell type-specific transcript expression in these two populations of pyramidal cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13158

208 Samples

Download data: CEL

(Submitter supplied) Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

404 Samples

Download data: CEL

(Submitter supplied) cDNA microarray screening for gene expression changes in peripheral blood of eight half-marathon runners before (time point 0), immediately (time point 1) after and 24 h (time point 2) after exercise for details see publication: ... Keywords: repeat sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1962

8 Samples

Download data

(Submitter supplied) To identify genes dysregulated in bipolar disorder (BD1) we carried out global gene expression profiling using whole-genome microarrays. To minimize genetic variation in gene expression levels between cases and controls we compared expression profiles in lymphoblastoid cell lines from monozygotic twin pairs discordant for the disease. We identified 82 genes that were differentially expressed by ≥ 1.3-fold in 3 BD1 cases compared to their co-twins, and which were statistically (p ≤ 0.05) differentially expressed between the groups of BD1 cases and controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2779

Platform:

GPL570

6 Samples

Download data: CEL, CHP

Analysis of lymphoblastoid cell lines derived from 3 monozygotic twin pairs discordant for bipolar disorder. Results provide insight into the molecular pathogenesis of bipolar disorder.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 3 other sets

Platform:

GPL570

Series:

GSE7036

6 Samples

Download data: CEL, CHP

(Submitter supplied) Male Sprague-Dawley albino rats (Charles River) initially weighting approximately 200 grams were randomly assigned to one of the following: 1) olanzapine (2 mg/kg/day, I.P.) (N=20) or 2) Saline (N=20) and administered olanzapine or saline for 21 days. Frontal cortex (N=4/group) was dissected and homogenized for microarray, QPCR and western blotting following previous methods (Fatemi et al. 2003; Brooks et al. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2608

Platform:

GPL1355

8 Samples

Download data

Analysis of brain frontal cortices of albino Sprague-Dawley males treated with olanzapine for 21 days. Olanzapine is a second generation antipsychotic agent. Results provide insight into the molecular basis of the clinical response to olanzapine.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1355

Series:

GSE2547

8 Samples

Download data