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Series GSE5390 Query DataSets for GSE5390
Status Public on Jul 27, 2007
Title Expression profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to characterise for the first time the human adult Down syndrome brain
Keywords: disease state analysis
Overall design RNA extracted from human postmortem brain tissue from adult subjects with Down syndrome and healthy controls was hybridised to Affymetrix HG-U133A GeneChips to identify differentially expressed genes in the disease state.
Contributor(s) Bahn S, Lockstone HE, Wiseman Harris LJ, Swatton JE, Wayland MT, Jackson ES
Citation(s) 17950572
Submission date Jul 25, 2006
Last update date Apr 27, 2020
Contact name Sabine Bahn
Organization name University of Cambridge
Lab Cambridge Centre for Neuropsychiatric Research
Street address Tennis Court Road
City Cambridge
ZIP/Postal code CB2 1QT
Country United Kingdom
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (15)
GSM123264 brain_Down_syndrome_sampleid_jg1734
GSM123265 brain_Down_syndrome_sampleid_jg1737
GSM123266 brain_Down_syndrome_sampleid_jg1738
BioProject PRJNA96183

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GSE5390_RAW.tar 50.3 Mb (http)(custom) TAR (of CEL)

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