GEO DataSets

Analysis of CD4+ splenocytes 6 hours after surgically induced sepsis. CD4+ splenocytes either undergo apoptosis or become Th2 polarized within 24 hours of the onset of sepsis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL1261

Series:

GSE4479

10 Samples

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(Submitter supplied) Lymphocytes are adversely affected during sepsis. Some CD4+ splenocytes undergo apoptosis while others become Th2 polarized. The molecular determinants of these phenotypic changes are not known. Here we compare the transcriptional response of septic CD4 splenocytes to CD4 splenocytes from sham-manipulated animals 6h after sepsis and identify an early transcriptional component to the septic CD4+ splenocyte phenotype. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2092

Platform:

GPL1261

10 Samples

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(Submitter supplied) Background: We hypothesized that spleen microarray gene expression profiles analyzed with contemporary pathway analysis software would provide molecular pathways of interest and target genes that might help explain the affect of bcl-2 on improving survival during sepsis. Methods: Two mouse models of sepsis, cecal ligation and puncture and tracheal instillation of Pseudomonas aeruginosa, were tested in both wild-type mice and mice that overexpress bcl-2. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL339

41 Samples

Download data: CEL

(Submitter supplied) The aim of this series of experiments was to gain experience in sepsis gene expression profiling in a well-accepted model of murine polymicrobial abdominal sepsis and begin characterizing (in the parlance of genomics) the sepsis "transcriptome." DESIGN: Prospective animal study. SETTING: University-based animal research facility.SUBJECTS C57BL/6 mice. INTERVENTIONS: After induction of general anesthesia, cecal ligation and puncture were performed to induce peritonitis and polymicrobial sepsis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS164

Platform:

GPL207

6 Samples

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C57/B6 mice subjected either to sham laparotomy or cecal ligation and puncture (CLP) and spleen samples taken 24 hours post surgery. Effort to increase understanding of shock and the adaptive response to injury at the level of the entire genome.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 shock sets

Platform:

GPL207

Series:

GSE510

6 Samples

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(Submitter supplied) Accuracy of sepsis prediction was obtained using cross-validation of gene expression data from 12 human spleen samples and from 16 mouse spleen samples. For blood studies, classifiers were constructed using data from a training data set of 26 microarrays. The error rate of the classifiers was estimated on seven de-identified microarrays, and then on a subsequent cross-validation for all 33 blood microarrays. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL80

61 Samples

Download data: CEL