Similar studies for GEO DataSets (Select 200237382) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Links from GEO DataSets

Items: 13

Select item 2002373821.

Cell-type-specific tumour sensitivity identified with a bromodomain targeting PROTAC in adenoid cystic carcinoma.

(Submitter supplied) Salivary gland adenoid cystic carcinoma (ACC) is a rare malignancy with limited treatment options. The development of novel therapies is hindered by a lack of preclinical models. We have generated several ACC patient-derived xenograft (PDX) lines that retain the physical and genetic properties of the original tumours, including the presence of the common MYB/MYBL1-NFIB translocation. Using these PDXs, we have developed the conditions for the generation of 2D and 3D ACC models that retain MYB expression and can be used for drug studies. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30173
6 Samples

Download data: TSV

Series

Accession:: GSE237382

ID:: 200237382

PubMed Similar studies

Select item 2000289962.

Xenograft model systems of adenoid cystic carcinoma

(Submitter supplied) Adenoid cystic carcinoma (ACC) is one of the most common malignancies that arise in the salivary glands, with an incidence of 4.5 per 1,000,000. It can also arise in glandular tissue closely related to salivary glands in the lacrimal gland, nasal passages and tracheobronchial tree, as well as in glands of the breast and vulva. At all of these sites, it is characterized by a distinctive histology of basaloid epithelial cells arranged in cribriform or tubular patterns, usually demonstrating abundant hyaline extracellular matrix secretion and some degree of myoepithelial differentiation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3977
Platform:: GPL570
22 Samples

Download data: CEL

Series

Accession:: GSE28996

ID:: 200028996

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 39773.

Adenoid cystic carcinoma xenograft models

Analysis of xenograft tumors derived from clinical samples of adenoid cystic carcinomas (ACC) implanted into immunodeficient nu/nu mice within 36 hrs of tissue being removed from the human subjects. Results provide insight into molecular mechanisms underlying the pathology of ACC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 13 other, 2 tissue sets

Platform:: GPL570
Series:: GSE28996
22 Samples

Download data: CEL

DataSet

Accession:: GDS3977

ID:: 3977

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000888044.

Expression data of 13 surgical samples of adenoid cystic carcinoma (ACC), 2 ACC xenografts, and 7 normal salivary gland tissues (NSGs)

(Submitter supplied) This experiment investigates differences in global gene expression between ACC and NSG.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
22 Samples

Download data: CEL, CHP

Series

Accession:: GSE88804

ID:: 200088804

Select item 2000760945.

Expression data after knockdown of MYB-NFIB and IGF1R/INSR inhibition in ACC cells

(Submitter supplied) The MYB-NFIB gene is a driver-mutation in the majority of adenoid cystic carcinomas (ACCs) and believed to control a large number of genes involved in tumorigenesis. This experiment investigates the effects on gene expression after siRNA knock-down of MYB-NFIB and/or inhibition of IGF1R/INSR signaling in ACC cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
18 Samples

Download data: CEL, CHP

Series

Accession:: GSE76094

ID:: 200076094

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000980086.

Retinoic acid suppresses MYB in adenoid cystic carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
18 Samples

Download data: NARROWPEAK

Series

Accession:: GSE98008

ID:: 200098008

PubMed Full text in PMC Similar studies

Select item 2000980077.

Retinoic acid suppresses MYB in adenoid cystic carcinoma [RNA-seq]

(Submitter supplied) Translocations that drive overexpression of the oncogenic transcription factor MYB are molecular hallmarks of adenoid cystic carcinoma (ACC), a malignant salivary gland tumor. Surgical resection, whenever possible, is the standard therapy for ACC, but there are no available therapeutic options available if surgery fails. Here we performed a chemical genetic screen using a zebrafish embryo culture system and identified retinoic acid agonists as potent suppressors of c-myb. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: XLSX

Series

Accession:: GSE98007

ID:: 200098007

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000980068.

Retinoic acid suppresses MYB in adenoid cystic carcinoma [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: NARROWPEAK

Series

Accession:: GSE98006

ID:: 200098006

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001532309.

Integrated copy number and transcriptomic profiling reveal novel oncogenic drivers and clinically significant biomarkers in adenoid cystic carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL10123 GPL4091 GPL6244
137 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE153230

ID:: 200153230

Select item 20015322810.

Integrated copy number and transcriptomic profiling reveal novel oncogenic drivers and clinically significant biomarkers in adenoid cystic carcinoma [Agilent]

(Submitter supplied) We analyzed 100 patient samples by high-resolution arrayCGH to study genomic imbalances in ACC.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL10123 GPL4091
100 Samples

Download data: TXT

Series

Accession:: GSE153228

ID:: 200153228

PubMed Similar studies

Select item 20015300211.

Integrated copy number and transcriptomic profiling reveal novel oncogenic drivers and clinically significant biomarkers in adenoid cystic carcinoma [Affymetrix]

(Submitter supplied) This experiment investigates global gene expression in adenoid cystic carcinoma (30) and normal salivary gland tissue (7).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
37 Samples

Download data: CEL, CHP

Series

Accession:: GSE153002

ID:: 200153002

Select item 20007646512.

An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma

(Submitter supplied) Translocation events are frequent in cancer and may create chimeric fusions or ‘regulatory rearrangements’ that drive oncogene overexpression. Here we identify super-enhancer translocations that drive overexpression of the oncogenic transcription factor MYB as a recurrent theme in adenoid cystic carcinoma (ACC). Whole-genome sequencing data and chromatin maps reveal distinct chromosomal rearrangements that juxtapose super-enhancers to the MYB locus. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL16791 GPL15520 GPL18573
46 Samples

Download data: BED, TDF

Series

Accession:: GSE76465

ID:: 200076465

PubMed Full text in PMC Similar studies

Select item 20021017113.

Single cell RNA-sequencing identifies a paracrine interaction that may drive oncogenic Notch signaling in human adenoid cystic carcinoma

(Submitter supplied) Salivary adenoid cystic carcinoma (ACC) is a rare but biologically unique biphasic tumor, consisting of malignant myoepithelial and luminal epithelial cells. MYB and Notch signaling have been implicated in the pathophysiology of these tumors, but in vivo descriptions of these two programs in human tumors and investigation into their active coordination remain incomplete. We utilized single cell RNA-sequencing to profile human head and neck ACC, including the first comparison of primary ACC with a matched local recurrence. more...