Similar studies for GEO DataSets (Select 200223275) - GEO DataSets

Select item 2002232751.

Bulk RNA sequencing of MCPyV positive and negative patient derived Merkel cell carcinoma cell lines

(Submitter supplied) To investigate cell line intrinsic factors dictating cell fate and therapeutic vulnerabilities Gene expression profiling of cell lines based on their proximity and viral status

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
8 Samples

Download data: TXT

Series

Accession:: GSE223275

ID:: 200223275

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002334542.

Effect of Domatinostat treatment on MKL1 cells

(Submitter supplied) To investigate the effect of HDAC inhibition, we treated MKL1 cells with 10µM of domatinostat or vehicle control (DMSO) for 24h, and carried out bulk RNA-seq We then performed gene expression profiling analysis using data obtained from RNA-seq of vehicle control (DMSO treated) and domatinostat treated samples (in duplicates)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
4 Samples

Download data: TXT

Series

Accession:: GSE233454

ID:: 200233454

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002264383.

Single cell RNA-seq profiling of patient-derived Merkel cell carcinoma tumor samples

(Submitter supplied) Merkel cell carcinoma (MCC), a rare but aggressive neuroendocrine cancer of the skin, remains a challenge in the era of precision medicine. MCC tumor heterogeneity has been attributed to the variant disease etiologies, mediated by either UV exposure or Merkel cell polyomavirus (MCPyV). However, over the years it has become clear that these two groups are largely similar in clinical presentation, prognosis, and treatment response to immune-checkpoint inhibitors. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
11 Samples

Download data: MTX, TSV

Series

Accession:: GSE226438

ID:: 200226438

PubMed Full text in PMC Similar studies

Select item 2001481034.

Chromatin profiling upon pharmacological LSD1 inhibition in MCC [CUT&RUN]

(Submitter supplied) Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in a pharmacological screen and discovered that the lysine-specific histone demethylase 1A (LSD1/KDM1A) is required for MCC growth in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
16 Samples

Download data: BW

Series

Accession:: GSE148103

ID:: 200148103

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001481025.

Transcriptomic profiling of isolated mouse Merkel cells [SMARTseq]

(Submitter supplied) Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in a pharmacological screen and discovered that the lysine-specific histone demethylase 1A (LSD1/KDM1A) is required for MCC growth in vitro and in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: CSV

Series

Accession:: GSE148102

ID:: 200148102

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001478176.

Pharmacological LSD1 inhibition in MCC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL13112 GPL21697
50 Samples

Download data: BIGWIG, TSV, TXT

Series

Accession:: GSE147817

ID:: 200147817

PubMed Full text in PMC Similar studies

Select item 2001478167.

Transcriptomic maps of pharmacological LSD1 inhibition in MCC [SLAMseq]

(Submitter supplied) Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in a pharmacological screen and discovered that the lysine-specific histone demethylase 1A (LSD1/KDM1A) is required for MCC growth in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TSV

Series

Accession:: GSE147816

ID:: 200147816

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001478158.

Transcriptomic maps of pharmacological LSD1 inhibition in MCC [QUANTseq]

(Submitter supplied) Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in a pharmacological screen and discovered that the lysine-specific histone demethylase 1A (LSD1/KDM1A) is required for MCC growth in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE147815

ID:: 200147815

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001478149.

Genome-wide chromatin accessibility mapping upon pharmacological LSD1 inhibition in MCC [ATACseq]

(Submitter supplied) Merkel cell carcinoma (MCC) is a highly aggressive, neuroendocrine skin cancer that lacks actionable mutations, which could be utilized for targeted therapies. Epigenetic regulators governing cell identity may represent unexplored therapeutic entry points. Here, we targeted epigenetic regulators in a pharmacological screen and discovered that the lysine-specific histone demethylase 1A (LSD1/KDM1A) is required for MCC growth in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21697
4 Samples

Download data: BIGWIG

Series

Accession:: GSE147814

ID:: 200147814

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20018420710.

Viral Status Predicts Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Methylation profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL23976
66 Samples

Download data: IDAT

Series

Accession:: GSE184207

ID:: 200184207

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20018420611.

Viral Status Predicts Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma [Methylation]

(Submitter supplied) To understand the global methylation patterns in MCC cell lines

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL23976
16 Samples

Download data: IDAT

Series

Accession:: GSE184206

ID:: 200184206

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20017646612.

Viral Status Predicts Patterns of Genome Methylation and Decitabine Response in Merkel Cell Carcinoma [RNA-Seq]

(Submitter supplied) To understand the global methylation pattern in MCC

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
50 Samples

Download data: TXT

Series

Accession:: GSE176466

ID:: 200176466

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20004369913.

microRNA expression patterns related to merkel cell polyomavirus infection in human merkel cell carcinoma

(Submitter supplied) We performed miRNA expression profiling in a series of human Merkel Cell carcinoma samples using a microarray approach. Significant differentially expressed miRNAs among groups were identified using SAM analysis.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL16541
16 Samples

Download data: TXT

Series

Accession:: GSE43699

ID:: 200043699

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015971414.

Classical and variant Merkel cell carcinoma cell lines display different degrees of epithelial-mesenchymal transition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array; Methylation profiling by array

Platforms:: GPL19956 GPL23976 GPL20275
30 Samples

Download data: IDAT, RCC

Series

Accession:: GSE159714

ID:: 200159714

Select item 20015971015.

Classical and variant Merkel cell carcinoma cell lines display different degrees of epithelial-mesenchymal transition [methylation]

(Submitter supplied) variant MCC cell lines show differential methylation for EMT related genes and microRNAs in comparison to classcial MCC cell lines

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL23976
11 Samples

Download data: IDAT

Series

Accession:: GSE159710

ID:: 200159710

Select item 20015969616.

Classical and variant Merkel cell carcinoma cell lines display different degrees of epithelial-mesenchymal transition [miRNA]

(Submitter supplied) variant MCC cell lines show lower expression levels of the EMT-related microRNAs miR-200c-141 and miR-183-96-182 in contrast to classcial MCC cell lines

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL20275
11 Samples

Download data: RCC

Series

Accession:: GSE159696

ID:: 200159696

Select item 20015966217.

Classical and variant Merkel cell carcinoma cell lines display different degrees of epithelial-mesenchymal transition [mRNA]

(Submitter supplied) variant MCC cell lines show higher expression levels of the EMT-related genes, similar to that of SCC cell lines but opposite to classcial MCC cell lines

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL19956
8 Samples

Download data: RCC

Series

Accession:: GSE159662

ID:: 200159662

Select item 20018905418.

Next-generation mRNA sequencing of MKL-1 Merkel cell carcinoma cells expressing wild-type or mutant YAP or TAZ

(Submitter supplied) The overarching goal of this study was to characterize TEAD-dependent transcriptional effects of YAP and TAZ in Merkel cell carcinoma cells. To that end, transcriptional profiling was performed on MKL-1 cells induced to express GFP, wild-type YAP or TAZ, or YAP S94A or TAZ F52A for 3 days.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
15 Samples

Download data: TXT

Series

Accession:: GSE189054

ID:: 200189054

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20005045119.

Microarray analysis of Merkel cell carcinoma (MCC) tumors, small cell lung cancer (SCLC) tumors, and MCC cell lines

(Submitter supplied) When using cell lines to study cancer, phenotypic similarity to the original tumor is paramount. Yet, little has been done to characterize how closely Merkel cell carcinoma (MCC) cell lines model native tumors. To determine their similarity to MCC tumor samples, we characterized MCC cell lines via gene expression microarrays. Using whole transcriptome gene expression signatures and a computational bioinformatic approach, we identified significant differences between variant cell lines (UISO, MCC13, and MCC26) and fresh frozen MCC tumors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL570 GPL571
77 Samples

Download data: CEL, TXT

Series

Accession:: GSE50451

ID:: 200050451

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20016087820.

A novel DNA methylation signature in Merkel Cell Carcinoma

(Submitter supplied) Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with neuroendocrine features. Although the role of epigenetic in tumorigenesis has been documented in most type of cancer, it is overlooked in MCC. The treatment options for MCC is limited and the five-year survival rate remains as low as 33%. In addition, recent studies have suggested multiple mechanisms of epigenetic dysregulation that may contribute to loss H3K27me3 and the tumorigenesis in MCC but not well studied. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL23976
21 Samples

Download data: IDAT, TXT

Series

Accession:: GSE160878

ID:: 200160878

PubMed Full text in PMC Similar studies Analyze with GEO2R

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