Similar studies for GEO DataSets (Select 200218544) - GEO DataSets

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Items: 20

Select item 2002185441.

Gene expression profile at single cell level of tumor cells and immune cells from mouse SCLC tumors and preSC allograft samples.

(Submitter supplied) Small cell lung carcinoma (SCLC) is a lethal neuroendocrine type of lung cancer with limited therapeutic options. We used single cell RNA sequencing (scRNA-seq) to study SCLC tumogenesis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE218544

ID:: 200218544

PubMed Full text in PMC Similar studies

Select item 2002299822.

Gene expression profiles at single cell level of lung epithelial cells from the Cracd WT and Cracd KO mice

(Submitter supplied) Tumor cell plasticity contributes to intratumoral heterogeneity and therapy resistance. Through cell plasticity, lung adenocarcinoma (LUAD) cells transform into neuroendocrinal (NE) cell-like tumor cells. However, the mechanisms of NE cell plasticity remain unclear. Depletion of CRACD tumor suppressor results in the de-repression of NE-related gene expression in the pulmonary epithelium. Similarly, Cracd KO augments intratumoral heterogeneity with upregulation of NE markers in LUAD animal models. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: H5AD

Series

Accession:: GSE229982

ID:: 200229982

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Select item 2002262663.

Modeling, dissecting, and subtyping of E-cadherin inactivation-associated diffuse-type gastric adenocarcinoma

(Submitter supplied) Diffuse-type gastric adenocarcinoma (DGAC) is lethal cancer that is often diagnosed late and resistant to therapeutics. Although hereditary DGAC is mainly characterized by mutations in the CDH1 gene that encodes E-cadherin, the impact of E-cadherin inactivation in DGAC tumorigenesis remains unclear. To address this, we established and characterized a CDH1 loss-associated DGAC model system with a human DGAC single-cell transcriptome. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
3 Samples

Download data: MTX, TSV

Series

Accession:: GSE226266

ID:: 200226266

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Select item 2001681954.

Identification of intrinsically immunogenic small cell lung carcinoma (SCLC) subpopulations

(Submitter supplied) SCLC is molecularly and immunologically heterogenous. Here, using transcriptional and epigenomic profiling of plastic SCLC states in human and mouse cell lines, and patient samples, we define the phenotype of a SCLC population marked by increased MHC Class I antigen presentation.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: BED

Series

Accession:: GSE168195

ID:: 200168195

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002058805.

Effects of loss of LSD1 activity on small cell lung cancer cell lines via pharmacological inhibition

(Submitter supplied) To investigate the effects of loss of LSD1 (KDM1A) on differential gene expression, we treated two cell lines of small cell lung cancer with 1 M LSD1 inhibitor ORY-1001 or vehicle control for 10 days. We then performed gene expression profiling analysis on treated and control cells for each of the two cell lines.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
12 Samples

Download data: TXT

Series

Accession:: GSE205880

ID:: 200205880

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001175526.

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
49 Samples

Download data: TXT

Series

Accession:: GSE117552

ID:: 200117552

PubMed Full text in PMC Similar studies

Select item 2001175517.

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [thyroid]

(Submitter supplied) This study assessed tumor suppressor roles of CREBBP in SCLC and other neuroendocrine tumors. Genetically engineered mouse models were used to determine the tumor suppressor role of Crebbp in SCLC and other neuroendocrine tumors.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE117551

ID:: 200117551

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001175508.

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [preSC cell line]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE117550

ID:: 200117550

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Select item 2001175499.

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [pituitary tumor]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
17 Samples

Download data: TXT

Series

Accession:: GSE117549

ID:: 200117549

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011754710.

Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [SCLC]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: TXT

Series

Accession:: GSE117547

ID:: 200117547

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20020861411.

Inhibition of LSD1 with bomedemstat sensitizes small cell lung cancer to immune checkpoint blockade and T cell killing

(Submitter supplied) The addition of immune checkpoint blockade (ICB) to platinum/etoposide chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment. However, ICB addition only modestly improved clinical outcomes, likely reflecting the high prevalence of an immunologically “cold” tumor microenvironment in SCLC, despite high mutational burden. Nevertheless, some patients clearly benefit from ICB and recent reports have associated clinical responses to ICB in SCLC with A) decreased neuroendocrine characteristics and B) activation of NOTCH signaling. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL30172
34 Samples

Download data: TXT

Series

Accession:: GSE208614

ID:: 200208614

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Select item 20017547912.

Inactivation of the LKB1 substrate AMPK accelerates lung adenocarcinoma and leads to immune evasion.

(Submitter supplied) Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TME) and resistance to immunotherapy. The mechanisms underpin the establishment and maintenance of a cold TME in LKB1 mutant LUAD remain poorly understood and the identification of downstream effectors is critical to inform therapeutic strategies to invigorate antitumor immunity. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE175479

ID:: 200175479

PubMed Similar studies SRA Run Selector

Select item 20012938213.

An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Sarcophilus harrisii; Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057 GPL26397
54 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE129382

ID:: 200129382

PubMed Full text in PMC Similar studies

Select item 20012938114.

An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [RNA-Seq]

(Submitter supplied) Loss of MHC class I (MHC-I) antigen presentation in cancer cells can lead to immunotherapy resistance. Using a genome-wide CRISPR/Cas9 screen we identify a critical role for polycomb repressive complex 2 (PRC2) in the coordinated transcriptional silencing of the MHC-I antigen processing pathway (MHC-I APP). This evolutionarily conserved function of PRC2 promotes evasion of T-cell mediated immunity, enabling tumour transmission to non-histocompatible recipients in small cell lung cancer (SCLC) and Tasmanian Devil Facial Tumour. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057
30 Samples

Download data: TXT

Series

Accession:: GSE129381

ID:: 200129381

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012938015.

An evolutionarily conserved function of polycomb silences the MHC class I antigen presentation pathway and enables immune evasion in cancer [ChIP-Seq]

(Submitter supplied) Loss of MHC class I (MHC-I) antigen presentation in cancer cells can lead to immunotherapy resistance. Using a genome-wide CRISPR/Cas9 screen we identify a critical role for polycomb repressive complex 2 (PRC2) in the coordinated transcriptional silencing of the MHC-I antigen processing pathway (MHC-I APP). This evolutionarily conserved function of PRC2 promotes evasion of T-cell mediated immunity, enabling tumor transmission to non-histocompatible recipients in small cell lung cancer (SCLC) and Tasmanian Devil Facial Tumor. more...

Organism:: Sarcophilus harrisii; Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL19057 GPL26397
24 Samples

Download data: BROADPEAK, NARROWPEAK

Series

Accession:: GSE129380

ID:: 200129380

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009931616.

Gene repression and ChIP-seq in Human Small Cell Lung Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

4 related Platforms
75 Samples

Download data: BED, CEL

Series

Accession:: GSE99316

ID:: 200099316

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009931217.

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer

(Submitter supplied) Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis. Expression array analysis of 23 SCLC cases and 42 normal tissues revealed that EZH2 and other PRC2 members were highly expressed in SCLC. ChIP-seq for H3K27me3 suggested that genes with H3K27me3(+) in SCLC were extended not only to PRC2-target genes in ES cells but also to other target genes such as cellular adhesion-related genes. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10999
5 Samples

Download data: BED

Series

Accession:: GSE99312

ID:: 200099312

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004334618.

Gene repression with H3K27me3 modification in human small cell lung cancer

(Submitter supplied) Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis due to early dissemination and rapid growth. We here analyze gene expression profile of 23 clinical SCLC samples. EZH2 was found to be highly expressed in SCLC samples compared to 42 normal tissues including the normal lung, and other PRC2 members, SUZ12 and EED, were also highly expressed in SCLC. To obtain target genes of PRC2 in SCLC, H3K27me3 mark was mapped in three SCLC cell lines, Lu130, H209 and DMS53, and compared to normal small airway epithelial cells (SAEC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4794
Platforms:: GPL96 GPL97 GPL570
70 Samples

Download data: CEL

Series

Accession:: GSE43346

ID:: 200043346

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 479419.

Small cell lung cancers

Analysis of 23 clinical small cell lung cancer (SCLC) samples from patients undergoing pulmonary resection and 42 normal tissue samples including the lung. SCLC is a lung cancer subtype with poor prognosis. Results provide insight into the molecular mechanisms underlying SCLC.