Similar studies for GEO DataSets (Select 200146252) - GEO DataSets

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Items: 13

Select item 2001462521.

Disrupting mitochondrial copper distribution inhibits leukemic stem cell self-renewal

(Submitter supplied) Leukemic stem cells (LSC) rely on oxidative metabolism and are differentially sensitive to targeting mitochondrial pathways, which spares normal hematopoietic cells. A subset of mitochondrial proteins are folded in the intermembrane space via the mitochondrial intermembrane assembly (MIA) pathway. We found increased mRNA expression of MIA pathway substrates in acute myeloid leukemia (AML) stem cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18573 GPL24676
25 Samples

Download data: BIGWIG, TSV

Series

Accession:: GSE146252

ID:: 200146252

Select item 2000622232.

Gene expression change induced by TIM-3/galectin-9 interaction in primary AML

(Submitter supplied) Analysis of gene expression change after galectin-9 stimulation in primary CD34+TIM-3+ AML cells

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
6 Samples

Download data: IDAT

Series

Accession:: GSE62223

ID:: 200062223

Select item 2001074313.

Small RNA deep sequencing using Illumina HiSeq2500

(Submitter supplied) 33 miRNAs significantly decreased and 75 miRNAs significantly increased in BCR-ABL+ LSK compared with BCR-ABL- LSK cells, suggesting distinct BCR-ABL-dependent mechanisms of microRNA regulation.

Organism:: Mus musculus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: TXT

Series

Accession:: GSE107431

ID:: 200107431

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001019584.

miR-99 regulates normal and malignant hematopoietic stem cell self-renewal

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
13 Samples

Download data: TXT

Series

Accession:: GSE101958

ID:: 200101958

PubMed Full text in PMC Similar studies

Select item 2001019575.

RNA-sequencing of Scr or miR-99 KD L-GMPs from MLL-F9 AML secondary recipients

(Submitter supplied) We FACS purified L-GMP cells (GFP+ tdTom+ c-Kit+ Sca-1+ CD16/32+ CD34+) from mice transplanted with post-transformed Scr or miR-99 KD MLL-AF9 bone marrow and performed RNA-sequencing, demonstrating miR-99 KD results in induction differentiation and enrichment for a normal GMP gene expression signature

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE101957

ID:: 200101957

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001019036.

RNA-sequencing of stably engrafted miR-99 KD LSKs

(Submitter supplied) We FACS-purified GFP+ LSK cells from mice transplanted with stably engrafted miR-99 KD and Scr HSCs and performed RNA-sequencing, demonstrating miR-99 KD results in significant depletion of hematopoietic stem cell gene expression signature and induces a differentiated progenitor gene expression signature.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: TXT

Series

Accession:: GSE101903

ID:: 200101903

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001019027.

RNA-sequencing of GFP+ cells 2 days post-transduction of LSK cells with Scr or miR-99 KD lentiviral vectors

(Submitter supplied) We FACS purified GFP+ cells 2 days post-transduction of LSK (Lin-Negative c-Kit+ Sca1+) cells with miR-99 KD and Scr lentiviral vectors and performed RNA-sequencing; this allowed us to identify potential miR-99 target genes for inclusion in the shRNA library

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
5 Samples

Download data: TXT

Series

Accession:: GSE101902

ID:: 200101902

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000681728.

LAA expression profiles on LSC compared to other tissues

(Submitter supplied) Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. Leukemia associated antigens (LAA) might be suitable structures to be attacked by immunotherapeutic agents. We performed primary AML sample enrichment and microarray studies to define LAA expression levels in AML. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
77 Samples

Download data: CEL, CHP

Series

Accession:: GSE68172

ID:: 200068172

Select item 2000203779.

Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

(Submitter supplied) Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells is an important component of AML development We generated either MLL-AF9 mediated murine leukemias that originate from committed progenitor (GMP) cells or Hoxa9/Meis1a mediated murine leukemias that originate from hematopoietic stem cells (HSC). The leukemia stem cell fraction in these two type of leukemias shared a common self-renewal pathway with normal hematopoietic stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3839
Platform:: GPL8321
15 Samples

Download data: CEL

Series

Accession:: GSE20377

ID:: 200020377

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 383910.

Acute myelogenous leukemia stem cells

Analysis of acute myelogenous leukemia (AML) leukemia stem cells (LSC) induced either by Hoxa9/Meis1a oncogenes or MLL-AF9 oncoprotein. LSC self-renewal pathway in myeloid cells is central to AML development. Results provide insight into the molecular mechanisms underlying development of LSC in AML.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 cell line, 5 cell type, 2 disease state sets

Platform:: GPL8321
Series:: GSE20377
15 Samples

Download data: CEL

DataSet

Accession:: GDS3839

ID:: 3839

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20012325511.

All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia

(Submitter supplied) Ecotropic virus integration site 1 (EVI1), whose overexpression characterizes a particularly aggressive subtype of acute myeloid leukemia (AML), enhanced anti-leukemic activities of all-trans retinoic acid (atRA) in cell lines and patient samples. However, the drivers of leukemia formation, therapy resistance, and relapse are leukemic stem cells (LSCs), whose properties were hardly reflected in these experimental setups. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
10 Samples

Download data: TXT

Series

Accession:: GSE123255

ID:: 200123255

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003404412.

Gene expression profiles of AML derived stem cells: similarity to hematopoietic stem cells

(Submitter supplied) Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34‏CD38_ cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC). We isolated the CD34‏CD38_ cell fraction from AML and compared their gene expression profiles to the CD34‏CD38‏ cell fraction, using microarrays. We found 409 genes that were at least twofold over- or underexpressed between the two cell populations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4301
Platform:: GPL571
8 Samples

Download data: CEL

Series

Accession:: GSE34044

ID:: 200034044

Select item 430113.

Acute myeloid leukemia CD34+CD38- cell population

Analysis of CD34+CD38- and CD34+CD38+ cell fractions isolated from 5 acute myeloid leukemia (AML) patients. AML CD34+CD38- cells are enriched leukemic stem cells (LSC) that maintain the propagation of the disease. Results provide insight into molecular mechanisms that maintain and characterize LSC.